Adenoid Cystic Carcinoma of Bartholin’s Gland

Nasu, Kaei; Kawano, Yukie; Takai, Noriyuki; Kashima, Kenji; Miyakawa, Isao

doi:10.1159/000081468

Cited by 27 publications

(4 citation statements)

References 27 publications

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“…Adjuvant radiation is also used to treat ACCBGs with a range of doses though there is no consensus regarding the role, extent, or total dose of radiation [23]. It is recommended especially in patients with positive margins on resection [24, 25]. Previous case reports [12, 26–28] have reported radiotherapy doses ranging from 50.4 Gy to 66 Gy [27].…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Leow

Naing

et al. 2019

Case Reports in Obstetrics and Gynecology

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Adenoid cystic carcinomas of the Bartholin’s gland are extremely rare and are often misdiagnosed. There are currently no definite treatment guidelines. This article describes the case of a 33-year-old female who was managed at our centre for adenoid cystic carcinoma of the Bartholin’s gland. She presented with a prolonged history of a vulvar lesion which was eventually diagnosed as adenoid cystic carcinoma of the Bartholin’s gland. She was subsequently treated with wide local excision of the primary and inguinal lymph node dissection followed by adjuvant radiotherapy and chemotherapy. She had gross perineural invasion on MRI imaging. The present case highlights the diagnostic dilemma in this extremely rare cancer and the literature further explores the natural history and treatment options.

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Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Leow

Naing

et al. 2019

Case Reports in Obstetrics and Gynecology

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“…BGC is a rare malignancy and accounts for fewer than 5% of all vulvar carcinomas ( 7 ). SCNC arising in BG is extremely rare, and only 3 cases have been reported in English literature ( 3 ). A foreign language literature search was not performed.…”

Section: Discussionmentioning

confidence: 99%

“…Primary carcinoma of the Bartholin's gland (BGC) is an extremely rare malignancy accounting for <5% of all vulvar malignancies and representing 0.001% of gynecological cancers in the United States ( 1 – 3 ). Adenocarcinoma (ACC) and squamous cell carcinoma (SCC) are the predominating types of carcinoma at this site, occurring alongside ~80% of cases of BGC (equal frequency between ACC and SCC) ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Primary small cell neuroendocrine carcinoma of the Bartholin's gland: A case report

Wang

et al. 2018

Oncol Lett

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Primary carcinoma of the Bartholin's gland (BG) is a rare malignancy. There are extremely rare cases of small cell neuroendocrine carcinoma (SCNC) of the BG reported in the English literature. A postmenopausal female presented with a 1-month history of increasing pain and swelling on the left vulva consistent with spontaneously bleeding. Pathology identified SCNC that arose in BG. The patient was treated with a radical wide local excision and bilateral inguinal lymph node dissection followed by six courses of chemotherapy. One month after primary treatment, without any pelvic recurrence or abnormal tumor markers indications, distant metastasis of the liver was diagnosed and VI hepatic lobectomy was performed. The patient maintained regular adjuvant chemotherapy every month under outpatient surveillance and has no local recurrence or distant metastasis.

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“…Different histological variants have been described: adenocarcinomas, squamous cell carcinomas, transitional cell carcinomas and adenoid cystic carcinomas. The latter represent 10% to 15% of Bartholin’s gland tumors and arise usually from salivary, lacrimal and nasopharynx glands, and sometimes from mammary, skin and uterine cervix glands [2]. The mean age at diagnosis is around 50 years with a range between 25 and 80 years [3].…”

Section: Introductionmentioning

confidence: 99%

Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

et al. 2013

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IntroductionAdenoid cystic carcinoma of Bartholin’s gland is a very rare disease.Case presentationA 48-year-old premenopausal woman of Caucasian origin was delivered adjuvant pelvic and inguinal radiotherapy after prior complete left Bartholin’s gland tumor excision and inguinal lymph node dissection for adenoid cystic carcinoma of Bartholin’s gland with one metastatic inguinal lymph node.Two years after primary treatment, she presented to the Emergency Room with acute headache, hypoacousia, decrease in visual acuity, and a decrease in right leg muscle strength. A cranial magnetic resonance imaging scan demonstrated three cystic brain lesions with associated perifocal edema. Chest and abdomen computed tomography scans and a magnetic resonance imaging scan of the pelvis did not find any metastatic or residual disease elsewhere. A physical examination found no local recurrence.Stereotactic brain biopsies with pathology examination revealed the presence of adenoid cystic carcinoma metastasis. She thus received 30Gy of brain radiotherapy but, three months later, the brain lesions did not decrease in size and left mid lobular lung lesions appeared on her chest computed tomography scan. A mid left lobe lung excision was undertaken followed by chemotherapy consisting of six cycles of cyclophosphamide, adriamycin and cisplatin. Five months after beginning chemotherapy, the brain disease progressed and our patient died.ConclusionOur case report shows the difficulty in managing brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma as no consensus on the optimal treatment exists.

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Adenoid Cystic Carcinoma of Bartholin’s Gland

Cited by 27 publications

References 27 publications

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Primary small cell neuroendocrine carcinoma of the Bartholin's gland: A case report

Brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma: a case report

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