Primary small cell neuroendocrine carcinoma of the Bartholin's gland: A case report

Abstract

Primary carcinoma of the Bartholin's gland (BG) is a rare malignancy. There are extremely rare cases of small cell neuroendocrine carcinoma (SCNC) of the BG reported in the English literature. A postmenopausal female presented with a 1-month history of increasing pain and swelling on the left vulva consistent with spontaneously bleeding. Pathology identified SCNC that arose in BG. The patient was treated with a radical wide local excision and bilateral inguinal lymph node dissection followed by six courses of chemotherapy. One month after primary treatment, without any pelvic recurrence or abnormal tumor markers indications, distant metastasis of the liver was diagnosed and VI hepatic lobectomy was performed. The patient maintained regular adjuvant chemotherapy every month under outpatient surveillance and has no local recurrence or distant metastasis.

Advanced neuroendocrine carcinoma (Merkel cell carcinoma) of the vulva: a case report and literature review

“…To date, 18 cases of neuroendocrine carcinoma of the vulva have been described in the English literature, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] as well as 2 cases of neuroendocrine carcinoma of Bartholin's gland. 22,23 A recent systematic review on the subject by Nguyen et al 19 (in 2017) included 17 of these cases (16 cases of neuroendocrine carcinoma of the vulva and 1 case of neuroendocrine carcinoma of Bartholin's gland). Two further cases of neuroendocrine carcinoma of the vulva were documented by Aminimoghaddam et al 1 in 2016 and Correia et al 6 in 2017 ( Table 1).…”

“…(Clinical features and treatment of vulvar Merkel cell carcinoma: a systematic review. Gynecologic oncology research and practice 2017; 4: 2) under the Creative Commons Attribution 4.0 International License (available at http://creativecommons.org/licenses/by/4.0/), with the addition of three studies, Aminimoghaddam et al1 , Correia et al6 and Wu et al22 inTable 1; rows 1, 5 and 20.…”

A rare case of primary small cell neuroendocrine carcinoma of the Bartholin gland

“…Previous reports on the treatment of Bartholin gland SCNC involved surgical resection and chemoradiotherapy. The use of cisplatin and etoposide is recommended in the adjuvant chemotherapy of Bartholin gland SCNC, as it similarly is recommended in cases of pulmonary cancer 3 . It is important for more cases to be reported in the literature so that clinicians can develop optimal treatment principles.…”

“…The most frequent histological types of BGC are adenocarcinoma and squamous cell carcinoma. Only four cases of small cell neuroendocrine carcinomas arising in the Bartholin gland have been reported in the existing literature 1–4 …”

Carcinoma primario de células de Merkel vulvar

“…El CCM vulvar primario es una condición extremadamente rara, con menos de 20 casos reportados. Tiene un comportamiento agresivo y puede, en algunos casos, imitar la presentación clínica del absceso de la glándula de Bartolino (2,3) . Se presenta un caso de carcinoma primario de células de Merkel vulvar.…”