Adenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure

Abstract

Adenocarcinoma makes up only a small percent of all nasal and paranasal sinus carcinomas, and is most often found in the ethmoid sinuses. Adenocarcinoma of the ethmoid sinuses is known to be associated with exposure to wood dust. Twenty‐eight patients with ethmoid adenocarcinomas were collected, mainly during the last decade from a region with approximately 900,000 inhabitants and with a large amount of furniture industries. There were 4 women and 24 men in the study. Twenty of the men were exposed to dust from hardwood for 20 to 55 years (mean, 40 years) which is in accord with other reports and supports data on the increased risk for workers of developing adenocarcinoma of the ethmoid sinuses when exposed to dust from hardwood. Radiologic diagnosis is necessary to delineate the extent of these tumours, and computerized tomography (CT) especially furnishes important information. Most patients received preoperative radiotherapy followed by surgery, 50% of them survived 5 years, which is in accord with other reports.

Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance

“…We contend that subsequent genetic events, especially in the former, are most likely acquired during the progression as a result of locoregional and other epidemiological factors. [20][21][22][23][24][25][26][27] These results, along with the lack of any alteration in the seromucinous subtype, support a distinct pathway for the evolution and progression of the intestinal and primary colonic adenocarcinomas.…”

Head and Neck Cancer: Global Burden and Regional Trends in India

“…Although EBV has been consistently associated with lymphoepithelial carcinoma of the salivary glands in the Asian population, there is no evidence of its causal role in other primary salivary gland neoplasm (Tsai et al, 1996). The factors reported to be associated with cancer of salivary glands are prior childhood radiation of head and neck (Katz and Preston-Martin 1984), wood dust (Klitenberg et al, 1984), silica (Zheng et al, 1996), nitrosamines in rubber workers (Straif et al, 1999) and smoking (implicated in case of Warthin's tumour (Pinkston and Cole 1996)). Dietary analysis revealed a possible protective effect for a diet high in polyunsaturated fatty acids (Actis and Eynard 2000).…”

Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

“…Although ITACs are uncommon, they have generated interest not only because of their unusual histologic appearance but also, epidemiologically, as a result of their association with occupational exposure to wood and, occasionally, leather dust (95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107)(108)(109).…”