Adenocarcinoma of the Esophagus With Signet Ring Cell Features Portends a Poor Prognosis

Enlow, Jonathan M.; Denlinger, Chadrick E.; Stroud, Martha R.; Ralston, Jonathan; Reed, Carolyn E.

doi:10.1016/j.athoracsur.2013.06.047

Cited by 35 publications

(33 citation statements)

References 10 publications

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“…Enlow et al studied 151 patients who underwent oesophageal resection for either oesophageal or GOJ tumours of type Siewert I or II at a single US centre between 1998 and 2011 11. Local policy was for neoadjuvant chemoradiotherapy when possible.…”

Section: Resultsmentioning

confidence: 99%

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

Bleaney

Barrow

Hayes³

et al. 2017

J Clin Pathol

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AimTo review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis.MethodsWe conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised.ResultsSignet-ring cell carcinoma was represented in 7.61% of the 18 989 cases of oesophageal carcinoma reviewed in multiple studies. The presence of signet-ring cells conferred a worse prognosis and these tumours responded differently to conventional treatments as compared with typical adenocarcinoma. Little is known about the biological features of signet-ring cell adenocarcinoma of the oesophagus. Work in gastric lesions has identified potential targets for future treatments such as CDH1 and RHOA genes. Categorisation of signet-ring cell carcinomas by the proportion of signet-ring cells within tumours differs among clinicians despite WHO criteria for classification. The current UK guidelines for histopathological reporting of oesophageal tumours do not emphasise the importance of identifying signet-ring cells.ConclusionThe presence of signet-ring cells in oesophageal adenocarcinomas leads to poorer clinical outcomes. Current understanding of signet-ring cell biology in oesophageal cancer is limited.

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Section: Resultsmentioning

confidence: 99%

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

Bleaney

Barrow

Hayes³

et al. 2017

J Clin Pathol

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“…SRC carcinoma is a rare histologic variant of esophageal adenocarcinoma that has been recently increasing reported in the western countries[7]. Most of the published data reported the SRC carcinoma of the esophagus and esophagogastric junction [11–15].…”

Section: Discussionmentioning

confidence: 99%

“…Signet ring cell (SRC) carcinoma is a form of adenocarcinoma which was defined by the World Health Organization classification as those where more than 50% of the tumor consisted of isolated or small groups of malignant cells containing intracytoplasmic mucins[4]. The incidence of esophageal signet ring cell carcinomas is estimated to range from 3.5% to 5% for all esophageal malignancies in western studies [5–7]. Although these studies have reported on the incidence, clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus and the gastroesophageal junction, it has not been well studied in the Asian population.…”

Section: Introductionmentioning

confidence: 99%

The clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus: A 10-year retrospective study in China

et al. 2017

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ObjectivesThe aim of this study was to analyze the clinicopathological features and prognosis of esophageal signet ring cell (SRC) carcinoma in China.MethodsPatients with poorly differentiated adenocarcinoma were identified in two hospitals from January 2006 to June 2016. The patients were divided into three groups according to component of SRCs: SRC≥50% group, SRC < 50% group and non-SRC poorly differentiated adenocarcinoma group.ResultsFifty-seven patients had carcinoma (SRC≥50%), and 79 patients had tumors containing <50% SRCs, and 535 patients was in non-SRC poorly differentiated adenocarcinoma group. There were no significant differences among the three groups in clinicopathological characteristics. Patients in SRC≥50% group had a lower overall survival rate (at 3-year 37.6%versus71.1%; at 5-year 0% versus 43.3%; p<0.001) compared with the control group. Even survival outcome of patients in SRC < 50%was inferior to that of in control group (at 3-year 53.0%versus71.1%; at 5-year 25.9% versus 43.3%; p<0.001). Female sex, large tumor size and increasing TNM stage were independent prognostic factors for SRC ≥50% esophageal carcinoma patients.ConclusionsThe incidence of esophageal SRC carcinoma is relatively rare and the worst outcome is observed in the SRC≥ 50% group. It is necessary to explore new therapeutic modalities to achieve further improvements in the clinical outcome of these patients.

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“…12e14 A recently published study showed that patients with a SRC ADC of the oesophagus or OG junction responded less well to induction therapy and had decreased overall survival compared with patients with non-SRC histology. 15 The pathologic appearance and clinical behaviour of oesophageal SRCs are still not well defined and comparative studies between oesophageal and gastric tumours have never been conducted. Whether specific prognosis and tumour characteristics that were identified for gastric SRCs are applicable to oesophageal SRCs remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Signet ring cell adenocarcinomas: Different clinical–pathological characteristics of oesophageal and gastric locations

Piessen

Messager

Lefèvre

et al. 2014

European Journal of Surgical Oncology (EJSO)

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Adenocarcinoma of the Esophagus With Signet Ring Cell Features Portends a Poor Prognosis

Cited by 35 publications

References 10 publications

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

The clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus: A 10-year retrospective study in China

Signet ring cell adenocarcinomas: Different clinical–pathological characteristics of oesophageal and gastric locations

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