Signet ring cell adenocarcinomas: Different clinical–pathological characteristics of oesophageal and gastric locations

Piessen, Guillaume; Messager, Mathieu; Lefèvre, Jérémie H.; Goèré, Diane; Mabrut, Jean‐Yves; Meunier, Brigitte; Brigand, Cécile; Hamy, A.; Gléhen, Olivier; Mariette, C.

doi:10.1016/j.ejso.2014.04.019

Cited by 27 publications

(21 citation statements)

References 28 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This latter observation contrasts with results from a previous study by our group, which identified preoperative chemotherapy as an adverse prognostic factor for overall survival in SRC adenocarcinoma patients [6]. This discrepancy could be partly due to the inclusion of tumors of the esophagogastric junction in the first study [56]. Moreover, important prognostic factors identified in our more recent analysis, such as age, involvement of adjacent organs, extent of lymphadenectomy, and T, N, and M components of the TNM classification, were not included in the multivariate analysis performed in the first study.…”

Section: Discussioncontrasting

confidence: 56%

Is signet-ring cell carcinoma a specific entity among gastric cancers?

et al. 2015

View full text Add to dashboard Cite

Background The prognosis and chemoresistance of signet-ring cell (SRC) gastric adenocarcinoma have been reported and debated, and the utility of perioperative chemotherapy for such a tumor has been questioned. This study was performed to assess the impact of the SRC type on survival following resection of gastric adenocarcinoma, and to assess whether the prognostic factors (including perioperative chemotherapy) for non-SRC adenocarcinoma differed from those for SRC adenocarcinoma. Methods 1799 cases of adenocarcinoma that were consecutively treated from 1997 to 2010 in 19 French centers by subtotal or total gastrectomy were included in a retrospective study. A D2 lymphadenectomy was performed for antropyloric tumors, and a modified D2 for upper tumors. SRC adenocarcinoma was diagnosed based on the presence of isolated carcinoma cells containing mucin. Results A total gastrectomy was performed in 979 (54.4 %) patients. SRC adenocarcinoma was diagnosed in 899 (50 %) patients. Patients with an SRC tumor were more frequently female, younger, and malnourished, had lower ASA scores, and had larger tumors than non-SRC patients. Median survival in patients with non-SRC carcinoma was 51 months, as compared to 26 months in patients with SRC carcinoma (p \ 0.001). At multivariate analysis, SRC type remained an independent adverse prognostic factor (HR = 1.182). Factors that were prognostic in the SRC subgroup but not in the non-SRC subgroup were age [60 years, linitis, and involvement of adjacent organs. In contrast to non-SRC tumors, pre-and postoperative chemotherapy did not significantly impact on survival following resection of SRC adenocarcinoma. On behalf of the FREGAT (French Eso-GAstric Tumours) working group-FRENCH (Fédération de Recherche en Chirurgie).Electronic supplementary material The online version of this article (doi:10.1007/s10120-015-0564-2) contains supplementary material, which is available to authorized users. Conclusion In comparison to non-SRC adenocarcinoma, the SRC type has a worse prognosis, different prognostic factors, and is only poorly sensitive to perioperative chemotherapy. Non-SRC and SRC adenocarcinomas should be considered different entities in future therapeutic trials.

show abstract

Section: Discussioncontrasting

confidence: 56%

Is signet-ring cell carcinoma a specific entity among gastric cancers?

et al. 2015

View full text Add to dashboard Cite

show abstract

“…One study compared clinical outcomes in patients with SRC of the oesophagus with those with SRC of the stomach 15. Two further studies of pathological specimens provided evidence of the prevalence of SCR morphology but not prognosis 15 16…”

Section: Resultsmentioning

confidence: 99%

“…To compare SRC adenocarcinomas of the oesophagus and stomach, Piessen et al studied a database of patients undergoing surgical resection of oesophageal or GOJ adenocarcinoma between 1997 and 2010 at multiple centres in France 15. Siewert I and II tumours were categorised as oesophageal and Siewert III tumours as gastric.…”

Section: Resultsmentioning

confidence: 99%

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

Bleaney

Barrow

Hayes³

et al. 2017

J Clin Pathol

View full text Add to dashboard Cite

AimTo review the current understanding of signet-ring type oesophageal adenocarcinoma including evidence for prognosis.MethodsWe conducted a literature search of nine healthcare literature databases for articles detailing the biology and clinical outcomes of signet-ring cell adenocarcinoma of the oesophagus. The impact of signet-ring cell morphology was analysed and detailed in written text and tabular format. Current understanding of the biology of signet-ring cell adenocarcinoma of the oesophagus was summarised.ResultsSignet-ring cell carcinoma was represented in 7.61% of the 18 989 cases of oesophageal carcinoma reviewed in multiple studies. The presence of signet-ring cells conferred a worse prognosis and these tumours responded differently to conventional treatments as compared with typical adenocarcinoma. Little is known about the biological features of signet-ring cell adenocarcinoma of the oesophagus. Work in gastric lesions has identified potential targets for future treatments such as CDH1 and RHOA genes. Categorisation of signet-ring cell carcinomas by the proportion of signet-ring cells within tumours differs among clinicians despite WHO criteria for classification. The current UK guidelines for histopathological reporting of oesophageal tumours do not emphasise the importance of identifying signet-ring cells.ConclusionThe presence of signet-ring cells in oesophageal adenocarcinomas leads to poorer clinical outcomes. Current understanding of signet-ring cell biology in oesophageal cancer is limited.

show abstract

“…Most of the published data reported the SRC carcinoma of the esophagus and esophagogastric junction [11–15]. Literature on the clinical characteristics and long term outcome of the esophagus SRC carcinoma focused on Asian population and the SRC carcinoma of the esophagus (excluding esophagogastric junction) is limited.…”

Section: Discussionmentioning

confidence: 99%

The clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus: A 10-year retrospective study in China

et al. 2017

View full text Add to dashboard Cite

ObjectivesThe aim of this study was to analyze the clinicopathological features and prognosis of esophageal signet ring cell (SRC) carcinoma in China.MethodsPatients with poorly differentiated adenocarcinoma were identified in two hospitals from January 2006 to June 2016. The patients were divided into three groups according to component of SRCs: SRC≥50% group, SRC < 50% group and non-SRC poorly differentiated adenocarcinoma group.ResultsFifty-seven patients had carcinoma (SRC≥50%), and 79 patients had tumors containing <50% SRCs, and 535 patients was in non-SRC poorly differentiated adenocarcinoma group. There were no significant differences among the three groups in clinicopathological characteristics. Patients in SRC≥50% group had a lower overall survival rate (at 3-year 37.6%versus71.1%; at 5-year 0% versus 43.3%; p<0.001) compared with the control group. Even survival outcome of patients in SRC < 50%was inferior to that of in control group (at 3-year 53.0%versus71.1%; at 5-year 25.9% versus 43.3%; p<0.001). Female sex, large tumor size and increasing TNM stage were independent prognostic factors for SRC ≥50% esophageal carcinoma patients.ConclusionsThe incidence of esophageal SRC carcinoma is relatively rare and the worst outcome is observed in the SRC≥ 50% group. It is necessary to explore new therapeutic modalities to achieve further improvements in the clinical outcome of these patients.

show abstract

Signet ring cell adenocarcinomas: Different clinical–pathological characteristics of oesophageal and gastric locations

Cited by 27 publications

References 28 publications

Is signet-ring cell carcinoma a specific entity among gastric cancers?

Is signet-ring cell carcinoma a specific entity among gastric cancers?

The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus

The clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus: A 10-year retrospective study in China

Contact Info

Product

Resources

About