Adenocarcinoma of the Ampulla of Vater

Talamini, Mark A.; Moesinger, Robert C.; Pitt, Henry A.; Sohn, Taylor A.; Hruban, Ralph H.; Lillemoe, Keith D.; Yeo, Charles J.; Cameron, John L.

doi:10.1097/00000658-199705000-00015

Cited by 272 publications

(255 citation statements)

References 23 publications

Supporting

Mentioning

219

Contrasting

Unclassified

Order By: Relevance

“…6 Early detection but also biologic differences are held responsible for the better prognosis of ampullary tumors following pancreaticoduodenectomy compared with other periampullary tumors (median survival 30-50 months, 5-year survival rate 21-64%). [7][8][9][10][11][12][13] Histologically, several subtypes of ampullary carcinomas can be distinguished, obviously deriving from the different types of mucosa adjoining the Vaterian system. 1,14 According to the classification by the Armed Forces Institute of Pathology (AFIP) an intestinal type, resembling carcinomas of intestinal origin and a pancreatico-biliary type, resembling carcinomas of the extrahepatic bile ducts or the pancreas are the most common subtypes and account for 70-95% of cases.…”

mentioning

confidence: 99%

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

et al. 2009

View full text Add to dashboard Cite

Carcinomas of the Vaterian system are rare and presumably arise from preexisting adenomas (adenomacarcinoma-sequence). Usually, biopsies are obtained to confirm and specify endoscopic findings, but differentiating reactive atypia from dysplasia or dysplasia from invasive carcinoma can sometimes be difficult or even impossible on morphological criteria alone. In case of invasive carcinoma, furthermore, the precise classification of carcinoma subtypes needs to be established since the distinct subtypes differ significantly in terms of clinical outcome. The cell adhesion proteins CD24, P-cadherin and S100A4 were shown to be expressed in several carcinomas and in dysplastic epithelium but only rarely in normal mucosa. We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater. Although the expression of the cell adhesion proteins did not differ between the carcinoma subtypes, marked differences between normal mucosa, adenoma and carcinoma samples were observed. All marker proteins were expressed in less than 7% of normal mucosa samples (S100A4 in only 1% of cases) and showed an increasing expression from adenoma to invasive carcinoma. Our findings suggest that P-cadherin and S100A4 are helpful in discriminating normal mucosa or reactive atypia from neoplastic lesions. CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.

show abstract

mentioning

confidence: 99%

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, although the surgical resection rate has increased, this increase has not been accompanied by satisfactory improvements in survival. The 5-year survival rate of resected cases currently is reported to be only 4 -21% for pancreatic carcinoma, [1][2][3] 38% for carcinoma of the ampulla of Vater, 4 and 7.5-27% for biliary tract carcinoma. 1,[5][6][7] These findings indicate the limitations of surgical resection and emphasize the need for an adjuvant treatment.…”

mentioning

confidence: 99%

Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma?

Takada

Amano

Yasuda

et al. 2002

Cancer

571

135

View full text Add to dashboard Cite

show abstract

“…Unlike these papers, the present study showed no significant change in survival among Table 3 Table 3 Table 3 Table 3 Table 3 pancreatic fistula being the most important. Talamini et al 14 reported an overall survival at five years of 38% with an operative mortality of 3.8% and a surgical morbidity of 47%, the pancreatic fistula being most common groups of patients with positive and negative lymph node status.…”

Section: Results Results Results Resultsmentioning

confidence: 99%

Estudo da linfadenectomia radical comparada à linfadenectomia standard no tratamento cirúrgico do adenocarcinoma da papila de Vater

Albagli¹,

Carvalho²,

Mali³

et al. 2010

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

OBJETIVO: avaliar a morbidade e a mortalidade cirúrgica em pacientes submetidos a gastroduodenopancreatectomia (GDP) com linfadenectomia padrão e radical para adenocarcinoma de papila, analisando os fatores prognósticos com relação à sobrevida global e livre de doença. MÉTODOS: foram analisados retrospectivamente no período de 1999 a 2007, no Serviço de Cirurgia Abdômino-Pélvica do INCa-RJ, 50 casos de GDP para adenocarcinoma da papila duodenal divididos em dois grupos de acordo com a linfadenectomia (grupo A: linfadenectomia padrão e grupo B: linfadenectomia radical). RESULTADOS: A mediana de idade foi semelhante nos dois grupos, assim como a distribuição entre os sexos. Na comparação entre as linfadenectomias somente o número de linfonodos ressecados (grupo A: 12,3 e grupo B: 26,5) e o tempo operatório (grupo A: 421 e grupo B: 474) foram significativamente diferentes. Não ocorreram diferenças estatisticamente significativas nos dois grupos com relação a morbi-mortalidade operatória e tempo de internação. A sobrevida livre de doença (grupo A: 35 meses e grupo B: 51 meses) e sobrevida global (grupo A: 38 meses e grupo B: 53 meses) foi maior no grupo da linfadenectomia radical, porém não foram significantes estatisticamente. CONCLUSÃO: no presente estudo não ocorreram casos de linfonodos metastáticos para outros grupos nodais sem o acometimento linfonodal das cadeias pancreato-duodenais (13 e 17), sugerindo um padrão de disseminação linfonodal. Apesar da linfadenectomia radical apresentar taxas de sobrevida livre de doença e sobrevida global maiores esses dados não foram significativos estatisticamente. Novos estudos devem ser realizados para avaliar o real papel da linfadenectomia radical no adenocarcinoma da papila duodenal.

show abstract

Adenocarcinoma of the Ampulla of Vater

Cited by 272 publications

References 23 publications

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma?

Estudo da linfadenectomia radical comparada à linfadenectomia standard no tratamento cirúrgico do adenocarcinoma da papila de Vater

Contact Info

Product

Resources

About