Adenocarcinoma mucinosum of extrophy bladder: A rare case report

Hamid, Agus Rizal Ardy Hariandy; Mochtar, Chaidir Arif; Lisnawati, L.; Saraswati, Meilania; Matondang, Sahat; Affan, Muhammad Isa Fuad

doi:10.1016/j.ijscr.2021.106493

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Epidemiologically, global data has shown that bladder exstrophy occurs in approximately 2 out of 100,000 births [4,5]. In Senegal, the data is not well documented.…”

Section: Discussionmentioning

confidence: 99%

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Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases

Sine,

Feki,

Bagayogo

et al. 2024

IJCU

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The primary mucinous adenocarcinoma of the bladder is an extremely rare urologic entity, which is found in less than 2% of all urinary bladder tumors and is often presented as metastatic. The authors report two cases of bladder adenocarcinoma with epispadias bladder exstrophy complex in two adults. The first case was about a 40-year-old patient referred for management of an EEC evolving since birth. The examination on admission revealed a deterioration in general condition and a bladder plate seat of an ulcero-necrotic tumefaction 3 x 2,5 cm with complete epispadias. The ureteral meatus were visible on each side at the lower part of the plate. Biopsy of the ulcero-necrotic mass revealed a well-differentiated bladder adenocarcinoma. Radical cystectomy and urinary diversion with an ileal conduit, and an expanded local lymphadenectomy was Indicated but the patient died before performing surgery. The second case is about a 28-year-old patient referred for management of an EEC evolving since birth associated with bilateral groin hernia. He had a good general condition, a bladder plate with complete epispadias. Treatment was cystectomy with Bricker urinary. Histo-pathological examination of the specimen reveled mucinous adenocarcinoma of the bladder. After review of the literature, it is a histological type with a poor prognosis and the role of surgery and adjuvant treatment remains to be defined.

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“…Epidemiologically, global data has shown that bladder exstrophy occurs in approximately 2 out of 100,000 births [4,5]. In Senegal, the data is not well documented.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of this histological entity is generally poor due to its discovery at an advanced stage at diagnosis. In the general population the 5-year survival rate for this type of cancer is 35 to 55% [4]. To date, no data are available to evaluate the prognosis of adenocarcinoma in patients with bladder exstrophy [8].…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases

Sine,

Feki,

Bagayogo

et al. 2024

IJCU

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show abstract

“…Many reports indicate that patients with BEEC require lifelong management for complications 7–10 . Previous reports recommend that patients who receive surgery for UC‐associated BEEC should undergo annual cystoscopy 11,12 and CT 12 . Although no reports recommend ultrasound, it is noninvasive, easy to perform, and might be very useful.…”

Section: Discussionmentioning

confidence: 99%

“… 6 Many reports indicate that patients with BEEC require lifelong management for complications. 7 , 8 , 9 , 10 Previous reports recommend that patients who receive surgery for UC‐associated BEEC should undergo annual cystoscopy 11 , 12 and CT. 12 Although no reports recommend ultrasound, it is noninvasive, easy to perform, and might be very useful. A study noted that the median age of patients with UC in the defunctionalized bladder after surgery for BEEC was 39 years, with a report of its occurrence at age 48 years.…”

Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy‐epispadias complex

Morikawa,

Iwatsuki,

Naiki‐Ito

et al. 2023

IJU Case Reports

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IntroductionThe bladder exstrophy‐epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment.Case presentationWe report the case of a 44‐year‐old man with a hemorrhage from the external urethral meatus. He was diagnosed with bladder exstrophy‐epispadias complex and underwent urinary diversion with substitution cystoplasty and Mitrofanoff appendicovesicostomy. Because computed tomography and magnetic resonance imaging suggested invasive bladder carcinoma in the defunctionalized bladder, we performed a cystectomy. The patient was diagnosed with urothelial carcinoma with glandular differentiation. One month after the surgery, nivolumab adjuvant chemotherapy was administered. The patient showed no signs of recurrence or metastasis after the treatment.ConclusionThis is the first case of adjuvant nivolumab therapy for urothelial carcinoma with the bladder exstrophy‐epispadias complex.

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Adenocarcinoma mucinosum of extrophy bladder: A rare case report

Cited by 2 publications

References 8 publications

Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases

Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases

Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy‐epispadias complex

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