Adenocarcinoma arising in adenomyosis: report of an unusual case

Couto, Daniela; Mota, F.; Silva, Teresa; Oliveira, Carlos de

doi:10.1080/j.0001-6349.2004.00025b.x

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…They reviewed 4 cases of their own patients and 26 previously reported cases of patients in 2002 with malignant neoplasm arising from adenomyosis (2). We found 9 additional cases of patients with malignant neoplasms arising from adenomyosis in English literature (3)(4)(5)(6)(7)(8)(9)(10)(11). Most of the malignant tumors arising The diagnostic criteria for ovarian carcinoma arising from endometriosis were originally proposed by Sampson (12) and modified by Colman and Rosenthal (13) so as to apply the criteria to carcinomas developing from adenomyosis as follows: a) the carcinoma should be absent in the normally situated endometrium and elsewhere in the pelvis; b) the carcinoma should be actually observed to be arising from the epithelium of the areas of adenomyosis and not invading it from some other source; and c) endometrial stromal cells should be surrounding the aberrant glands to support the diagnosis of adenomyosis.…”

Section: Discussionmentioning

confidence: 90%

Clear Cell Adenocarcinoma Arising From Adenomyosis

Hirabayashi

Yasuda²,

Kajiwara³

et al. 2009

International Journal of Gynecological Pathology

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A 73-year-old postmenopausal Japanese woman presented with a complaint of slight fever and weight loss. An elevated level of CA125 in the blood favored a diagnosis of malignant uterine body tumor, but was not confirmed by endometrial cytology and biopsy. Resection of the uterus revealed a solid whitish tumor in the myometrium that was diagnosed as clear cell adenocarcinoma (CCA) arising from adenomyosis. There were transitions between endometrial epithelium of adenomyosis, noninvasive CCA, and invasive CCA. Immunohistochemical expression of hepatocyte nuclear factor-1beta supported the diagnosis of CCA. Only one other English language document pertaining to CCA arising from adenomyosis exists. Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial.

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