Pathology and physiopathology of adenomyosis

Bergeron, Christine; Amant, Frédéric; Ferenczy, Alex

doi:10.1016/j.bpobgyn.2006.01.016

Cited by 304 publications

(293 citation statements)

References 45 publications

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“…In the present study, the prevalence of AM in specimens from hysterectomies performed for the treatment of EEC was determined to be 12.8%, which was lower compared with the percentages reported by previous studies (8).…”

Section: Discussioncontrasting

confidence: 83%

“…AM is a benign condition defined as the presence of endometrial glands and stroma located ≥1 intermediate power field away from the native endomyometrial junction (6,7); notably, AM has been documented to coexist with EEC in 16-34% of hysterectomy specimens obtained for the treatment of EC (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…The significance of the presence of AM in estimating the prognosis of EEC is still debated, despite the fact that studies have reported an excellent prognosis for EEC with concomitant AM due to the lower histological grade and superficial MI detected in such cases (8)(9)(10)(11)(12). Neoplastic areas close to the Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation foci of AM typically have a smooth contour and are frequently surrounded by endometrial stroma with or without benign endometrial glands (6).…”

Section: Introductionmentioning

confidence: 99%

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Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation

et al. 2015

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Abstract.The aim of the current study was to diagnose the concomitant presence of adenomyosis (AM) in endometrioid endometrial cancer (EEC) in order to evaluate its value as an oncological prognostic marker. A retrospective analysis of 289 patients diagnosed with EEC who underwent total hysterectomy, bilateral salpingo-oophorectomy and pelvic-lymphadenectomy was conducted. The total cohort included 37 patients in Group A (those with concomitant AM and EEC) and 252 patients in Group B (those affected only by EEC). The following factors were evaluated: Presence or absence of AM, tumor grade, depth of myometrial invasion, tumor size, lymphovascular space involvement, lymph node status, peritoneal cytology, concomitant detection of endometrial atypical-hyperplasia or polypoid endometrial features and tumor stage according to the International Federation of Gynecology and Obstetrics (FIGO) classification. Uterine examination of different sections of uterine cervix, corpus, myomas and cervical or endometrial polyps was performed. The diagnosis of AM was confirmed when the distance between the lower border of the endometrium and the foci of the endometrial glands and stroma was >2.5 mm. Parametric and nonparametric statistical tests were performed when possible; continuous variables were analyzed using a Student's t-test, and categorical variables were analyzed by the χ 2 test or Fisher's exact test. The association between FIGO stage and group was determined to be significant: 83.8% of Group A patients were categorized as FIGO stage I, vs. 68.7% of Group B patients. In addition, Group A was associated with lower grades in FIGO stage, myometrial invasion, lymphovascular space involvement, lymph node involvement and tumor size. The findings suggest that the intraoperative evaluation of the presence of AM in patients with EEC may aid surgeons in estimating oncological risk and in selecting the most appropriate surgical treatment.

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Section: Discussioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation

et al. 2015

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“…3B). Interestingly, omissions in the myometrial layer were invaded by stromal and glandular cells from the endometrium reminiscent for a human disorder described as endometriosis interna or adenomyosis (Bergeron et al, 2006).…”

Section: Amhr2mentioning

confidence: 99%

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice

Wang¹,

Jia²,

Franken³

et al. 2011

Molecular and Cellular Endocrinology

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“…This theory states that endometrial cells invade the myometrium through the damaged endometrium and grow ectopically, subsequently leading to an adenomyotic lesion (3,4). The incidence of pregnancy, delivery, abortion and intrauterine device use has been demonstrated to be increased in patients with AD compared with healthy controls, thus supporting the theory of endometrial damage (4,5).…”

Section: Introductionmentioning

confidence: 99%