Adenocarcinoma arising in adenomyosis: report of an unusual case

Couto, D; Mota, Fernando; Silva, Teresa; Oliveira, Carla

doi:10.1111/j.0001-6349.2004.00025b.x

Cited by 15 publications

(10 citation statements)

References 8 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis of myometrial invasion arising from deep adenomyosis is challenging, particularly when carcinoma is present only in adenomyosis and absent in the endometrial surface, a rare but well-documented phenomenon. 20,21 Careful microscopic examination will help: invasion should be considered if there is contour irregularity with finger-like or frankly infiltrative glands arising from a well-demarcated glandular area. In addition, attention to the distribution of IFITM1 staining may prove useful.…”

Section: Discussionmentioning

confidence: 99%

IFITM1 Is Superior to CD10 as a Marker of Endometrial Stroma in the Evaluation of Myometrial Invasion by Endometrioid Adenocarcinoma

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

IFITM1 Is Superior to CD10 as a Marker of Endometrial Stroma in the Evaluation of Myometrial Invasion by Endometrioid Adenocarcinoma

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Adenomyosis is a benign entity characterised by the heterotopic growth of endometrial glands or stroma into the myometrium with adjacent smooth muscle hyperplasia [1]. Uterine adenomyosis usually manifests as diffuse disease involving the myometrium and the endometrial-myometrial junction, but it may appear as a focal lesion.…”

Section: Discussionmentioning

confidence: 99%

“…In our case, the tumour originated from the uterus on MRI, which was suggestive of a uterine tumour with subserosal growth and haemorrhagic change. Endometrioid adenocarcinoma can rarely arise from adenomyosis [1,2]. Motohara et al [9] reported the course of adenocarcinoma arising from adenomyosis on periodic MRI.…”

Section: Discussionmentioning

confidence: 99%

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Kh²,

Kim³

et al. 2011

BJR

View full text Add to dashboard Cite

ABSTRACT. There are several reports of adenocarcinoma developing within adenomyosis of the uterus, but imaging features of MRI, including diffusion-weighted imaging (DWI) and positron emission tomography (PET)-CT, have not been published. Herein we report a rare case of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis to emphasise the unusual growth features, as well as the imaging findings of the tumour on MRI and PET-CT.

show abstract

“…Rolly published the first report in 1897 (55). In our review, to date, 44 cases of malignant tumors arising from adenomyosis have been documented (48,51,(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70).…”

Section: Malignant Transformation Of Adenomyosismentioning

confidence: 99%

Pathogenesis and malignant transformation of adenomyosis (Review)

et al. 2012

View full text Add to dashboard Cite

Abstract. The aim of our review was to identify the current information with regard to the pathogenesis and malignant transformation of adenomyosis. The current literature was reviewed by searching MEDLINE/PubMed, using the following keywords: adenomyosis, myometrium, stromal cells, malignant transformation, pathogenesis, etiology, genome-wide and microarray. Early signs of the development of adenomyosis are considered to be the penetration of stromal cells into the inner layer of the myometrium. Adenomyosis smooth muscle cells are developed, possibly, through a remodeling pathway via reactivation of coelomic epithelial cells as a result of estrogeninduced epithelial mesenchymal transition. Smooth muscle cell hyperplasia and hypertrophy are a reflection of a reaction of the surrounding tissue. The development of adenocarcinoma arising from adenomyosis is a relatively rare occurrence. In our literature review, to date, 44 cases of malignant tumors arising from adenomyosis have been documented. Studies reporting results of genetic abnormalities, epigenetic changes, monoclonal expansion, mutational analysis and the inactivation of specific tumor suppressor genes are very few in this field. In conclusion, adenomyosis can be a precursor of some carcinomas. The exact molecular mechanisms that lead to the malignant transformation are poorly understood.

show abstract

Adenocarcinoma arising in adenomyosis: report of an unusual case

Cited by 15 publications

References 8 publications

IFITM1 Is Superior to CD10 as a Marker of Endometrial Stroma in the Evaluation of Myometrial Invasion by Endometrioid Adenocarcinoma

IFITM1 Is Superior to CD10 as a Marker of Endometrial Stroma in the Evaluation of Myometrial Invasion by Endometrioid Adenocarcinoma

Unusual manifestation of endometrioid adenocarcinoma arising from subserosal cystic adenomyosis of the uterus: emphasis on MRI and positron emission tomography CT findings

Pathogenesis and malignant transformation of adenomyosis (Review)

Contact Info

Product

Resources

About