Addressing the safety of hyaluronic acid dermal filler injections during the SARS CoV-2 pandemic worldwide vaccination

Buzzaccarini, Giovanni; Borin, Marco; Diffidenti, Bianca; Varì, Simona; Gioia, M.; Albini, María; Noventa, Marco; Laganà, Antonio Simone

doi:10.1016/j.bjps.2021.08.037

Cited by 7 publications

(9 citation statements)

References 3 publications

(2 reference statements)

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“…When a reaction occurs, all the authors in the literature suggest a waiting approach, as we did in our cases except one, the second where it was necessary to take oral prednisolone for three days. Some other authors have reported similar reaction to SARS-CoV-2 vaccine, but none with the booster dose without previous symptoms with the others [2][3][4][5][6][7] Probably, in these cases, the first two doses have activated the immune system with a reaction between the hyaluronic acid filler and the SARS-CoV-2 vaccine.…”

Section: Discussionmentioning

confidence: 89%

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Hyaluronic acid delayed inflammatory reaction after third dose of SARS‐CoV‐2 vaccine

Calvisi¹

2022

J of Cosmetic Dermatology

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Background Treatments based on hyaluronic acid represent one of the most largely used practice of esthetic medicine. In the literature, it has already been described delayed reaction after vaccine like flu vaccine mediated by T‐lymphocytes. Aim We report three cases of dermal filler reactions following mRNA vaccination against SARS‐CoV‐2; all the patients had received the filler months or even years before the vaccine. Patients Patient one: A 60‐year–old female patient that was treated one year ago in the lip developed swelling days after getting mRNA Pfizer Biotech vaccine. She received her booster of Pfizer vaccination one week before. Patient two: A 45‐year–old female patient treated in the lip two years before developed angioedema days after getting her booster of Pfizer Biotech vaccine. In this case, it was necessary to prescribe cortisone per os. Patient three: A 40‐year‐old female patient treated for the nasolabial fold five months before developed erythema and edema after receiving the booster of Moderna Vaccine. Results As demonstrated in our three case reports, even the booster of vaccine can cause delayed inflammatory reactions in patients that have previously received fillers. Conclusion Delayed inflammatory reactions in patients that have received filler in the past are uncommon and usually self‐limited. Those are the first example reported in the literature of reaction after the booster dose without any previous symptoms.

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Section: Discussionmentioning

confidence: 89%

“…Some other authors have reported similar reaction to SARS‐CoV‐2 vaccine, but none with the booster dose without previous symptoms with the others 2–7 …”

Section: Discussionmentioning

confidence: 92%

Hyaluronic acid delayed inflammatory reaction after third dose of SARS‐CoV‐2 vaccine

Calvisi¹

2022

J of Cosmetic Dermatology

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“…At this critical juncture for public health in our society, the benefits of vaccination in preventing potentially fatal diseases far outweigh the deficiencies of vaccines, physicians should strive to encourage vaccination, dispel misconceptions, and help patients complete the vaccination process on time. Moreover, a complete past and personal history of the patient should be obtained and the patient should be given full information before cosmetic treatment 85 . Patients who have received prosthetic implants or filler injections may choose a vaccine with a relatively low incidence of adverse reactions and be closely monitored for any immune reactions associated with the implant after receiving the vaccine.…”

Section: Discussionmentioning

confidence: 99%

Adverse reactions to cosmetic implants after COVID‐19 vaccination: A literature review

Cheng,

Cai,

Tang

2023

J of Cosmetic Dermatology

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BackgroundAs the world's population of people vaccinated with the COVID‐19 vaccine increases, adverse reactions are increasingly being reported. There have been progressive reports of the effects of COVID‐19 vaccination on cosmetic fillers or prostheses, but they have not been reviewed based on their clinical morphologic patterns. This article reviewed the progress of research on adverse reactions to cosmetic implants after COVID‐19 vaccination.MethodsWe researched the English‐language literature up to October 15, 2022, using predefined keywords to identify relevant studies about adverse reactions to cosmetic implants after the COVID‐19 vaccination, collecting patient characteristics, implant type, the time interval between vaccination and implantation or injection, time of onset, symptoms, treatments, and outcomes.ResultsAmong the adverse reactions to implants associated with COVID‐19 vaccination, we distinguished between (1) injectable fillers and (2) surgical prosthetic implants. The most common adverse reactions were at the site of hyaluronic acid injection and breast prosthesis after Pfizer vaccination, mainly DIRs, and mainly manifested as edema, rash, fever, and capsular contracture. This paper also reported the possible causes, treatments of DIRs, and limitations of current studies.ConclusionsIn this article, we attempted to investigate and discuss all the adverse reactions of cosmetic implants related to COVID‐19 vaccination in the current literature, to unmask these reactions and make a more accurate assessment of vaccine safety.

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“…Since, TSH-signalling is mediated by phosphatidyl-inositol-3-kinase (PI3K) pathway, the depletion of MI may be associated with development of hypothyroidism and supplementation with MI was shown to improve not only TSH levels, but also to reduce antithyroid antibodies and thyroid benign nodules size [53]. Combination of MI and melatonin seems to positively affect glucose metabolism also in menopausal transition [54], in addition to other specific, peculiar and innovative treatments which are gaining popularity for menopausal sexual impairment such as local hy-aluronic acid administration [55,56]. Interestingly, even though the SARS-CoV-2 pandemic influenced its application, the scientific debate is still ongoing and in favour of these innovative treatment [55,56].…”

Section: New Perspectivesmentioning

confidence: 99%

“…Combination of MI and melatonin seems to positively affect glucose metabolism also in menopausal transition [54], in addition to other specific, peculiar and innovative treatments which are gaining popularity for menopausal sexual impairment such as local hy-aluronic acid administration [55,56]. Interestingly, even though the SARS-CoV-2 pandemic influenced its application, the scientific debate is still ongoing and in favour of these innovative treatment [55,56]. Finally, since aromatase converts testosterone to estradiol, the inhibition of this enzyme by high levels of DCI can lead to increased (non-converted) levels of circulating androgens, which may play a beneficial role in several conditions, such as sexual dysfunction in both men and women [57,58].…”

Section: New Perspectivesmentioning

confidence: 99%

Inositols administration: further insights on their biological role

Coldebella¹,

Buzzaccarini²,

Ferrari³

et al. 2023

It Journ Gyn Obs

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In the last decades, inositols attracted a growing interest since the acknowledgement of their role in insulin-activated signalling pathways. Myo-inositol (MI) and D-Chiro Inositol (DCI) are the most important isoforms and their use as insulin-sensitizer in treatment of polycystic ovarian syndrome is well known. New discoveries have paved the way for a wide range of new applications. For this reason, we collected the most interesting ideas and updates regarding inositols therapy to reason on innovative uses, with a particular focus in the field of infertility. We reviewed recent literature on inositol with a particular focus in the field of ovarian function and infertility. Recent researches on inositols are focusing on different signalling pathways other than the insulin-sensitizing one, such as inflammation signalling or androgens modulation. Furthermore, MI and DCI act in different ways and dosage and ratio seem to have different effects in different organs. Indeed, the use of inositols is developing promisingly in situations other than the treatment of insulin resistance and this is opening up new perspectives for increasingly personalized and effective therapies.

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Addressing the safety of hyaluronic acid dermal filler injections during the SARS CoV-2 pandemic worldwide vaccination

Cited by 7 publications

References 3 publications

Hyaluronic acid delayed inflammatory reaction after third dose of SARS‐CoV‐2 vaccine

Hyaluronic acid delayed inflammatory reaction after third dose of SARS‐CoV‐2 vaccine

Adverse reactions to cosmetic implants after COVID‐19 vaccination: A literature review

Inositols administration: further insights on their biological role

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