Addressing Pediatric Mental Health Using Telehealth During Coronavirus Disease-2019 and Beyond: A Narrative Review

Cunningham, N.; Ely, Samantha; Garcia, Brittany N.; Bowden, Jennifer

doi:10.1016/j.acap.2021.06.002

Cited by 44 publications

(32 citation statements)

References 64 publications

(105 reference statements)

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“…Postsynaptic density-95 (PSD-95) is an excitatory postsynaptic marker (Chen et al, 2015;Coley and Gao, 2018), and synaptophysin is a synaptic plasticity-related protein (Janz et al, 1999;Hao et al, 2017;Xiang et al, 2018). Reductions of these synaptic markers suggest synaptic loss, potentially leading to cognitive impairment (Clare et al, 2010;Kaufman et al, 2015;Murmu et al, 2015;Hong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice

Lin

Shen

et al. 2021

Front. Aging Neurosci.

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Anesthesia/surgery has been reported to be associated with perioperative neurocognitive disorder (PND) in patients and induces cognitive impairment in mice. Previous studies demonstrate cyclosporine A (CsA) attenuates the anesthesia/surgery-induced cognitive impairment in mice. However, CsA has immunosuppressive effects and may not be routinely used to prevent or treat PND in patients. WS635 is a nonimmunosuppressive CsA analog. We, therefore, set out to determine whether WS635 could mitigate the anesthesia/surgery-induced cognitive impairment in mice. We performed abdominal surgery under 1.4% isoflurane anesthesia (anesthesia/surgery) for 2 h in 9 month-old wild-type (WT) mice. We treated the mice with CsA (10 mg/kg) or different doses (13.2 mg/kg, 26.4 mg/kg and 52.8 mg/kg) of WS635 before and after the anesthesia/surgery. Barnes maze and fear conditioning system (FCS) were employed to evaluate the cognitive function in mice. We measured the amounts of postsynaptic density (PSD)-95, synaptophysin, and ATP in the hippocampus and cortex of the mice using western blot and ATP Colorimetric/Fluorometric Assay, respectively. We found that the treatment with 52.8 mg/kg, but not 13.2 mg/kg or 26.4 mg/kg, of WS635 attenuated the anesthesia/surgery-induced cognitive impairment in mice and the reductions in the amounts of PSD-95, synaptophysin, and ATP in the mice brain tissues. These results have established a system to study WS635 further and suggest that we need to perform more experiments to determine whether WS635 can ultimately be used as one of the interventions for PND in patients.

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Section: Introductionmentioning

confidence: 99%

WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice

Lin

Shen

et al. 2021

Front. Aging Neurosci.

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“…Interestingly, the degree of overall web tool use (as defined by low, moderate, and high use) did not predict response to the ADAPT treatment. These findings are important as the demand for psychological treatment approaches for pediatric pain and anxiety that include remote interactions with live providers and self-paced web support tools will only continue to grow in the wake of the COVID-19 pandemic [39,40].…”

Section: Discussionmentioning

confidence: 99%

Engagement during a Mixed In-Person and Remotely Delivered Psychological Intervention for Youth with Functional Abdominal Pain Disorders and Anxiety

et al. 2021

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Functional abdominal pain disorders (FAPD) are common disabling pain conditions frequently associated with co-occurring mental health problems such as anxiety. Psychological therapies such as cognitive behavioral therapy (CBT) have been shown to be effective. Therefore, it is important to understand participant engagement (i.e., use of intervention tools) to such approaches, and if engagement impacts treatment response. The Aim to Decrease Anxiety and Pain Treatment (ADAPT) is an effective psychological treatment approach using a blend of in-person sessions and interventionist phone support with self-paced web modules to manage pain and anxiety. The current study used a mixed-methods approach to investigate micro-level and macro-level participant engagement during the ADAPT program. In-person/phone session attendance was high (>95%) although scheduling adjustments were common (25.5%). Varied levels of engagement with web tools were observed. Thematic analysis also revealed variability in patterns of use. Additionally, while participants indicated they generally understood how to use certain skills (e.g., problem solving, detective thinking), and these skills were effective in managing symptoms during treatment, these activities were generally underutilized. Further, participant engagement did not predict response to the ADAPT intervention. These findings are important as the demand for accessible psychotherapeutic tools to manage pain and anxiety is likely to remain high.

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“…TH has been used in a limited capacity in GI and pediatric medicine (Bestsennyy et al, 2020;Kriem & Rahhal, 2020;Sisk et al, 2020;Wosik et al, 2020). Prior to the pandemic, TH was commonly used in treatment of pediatric mental health issues, obesity, sleep problems, and chronic pain (Cunningham et al, 2021;McLean et al, 2021;Myers & Comer, 2016). It had also been used sporadically as an intervention to support families of children transitioning home following hospital discharge, including those with GI-related problems (Dick et al, 2004;Raphael et al, 2019).…”

Section: Available Knowledgementioning

confidence: 99%