Purpose: To review the extant literature relevant to perceptions by direct care nurses toward clinical research endeavors.Design: An integrative review guided by the socioecological model was conducted.Methods: Five databases were searched to identify relevant peer-reviewed articles; there was no limitation on publication date. Findings: The final sample (N = 9) was systematically appraised. Numerous barriers to direct care nurses' ability to perform study activities on clinical research trials were encountered at all levels: (1) personal-comprehension, education, and training; (2) interpersonal-communication issues within or from the study team, failure to advocate for the patient; (3) organizational-lack of leadership support, knowledge, and time; and (4) community-insufficient guidance and oversight by research-governing bodies.
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