Additives to intravenous fluids.

Parsons, R. L.; Beavis, J. P.; Paddock, Gillian M.; David, Jill; Trounce, J. R.

doi:10.1136/bmj.2.6046.1256-b

Cited by 5 publications

(2 citation statements)

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“…Parenteral chemotherapyroute and mode ofadministration Intravenous antibiotics are increasingly being used both for the treatment of septicaemia (Parsons et al, 1976a) and for the prophylaxis of infection during elective surgery, for example total hip replacement for osteoarthrosis of the hip (Willis, 1974;Parsons et al, 1978;1977). This mode of antibiotic administration has made it necessary to evaluate the pharmacokinetics and therapeutic efficacy after intravenous antibiotics, which may be given either as a bolus injection in the sidearm of the infusion tube or as a slow infusion over several hours.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man

Parsons¹,

Paddock²,

David³

et al. 1978

Postgraduate Medical Journal

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SummaryAs the pharmacokinetics after a slow infusion had not previously been evaluated in the doses used in this study, it was decided to measure the plasma concentration/time curve after a twelve-hour intravenous infusion of 2-0 g of erythromycin lactobionate in 2 litres of 0.9/o normal saline. Six healthy medical students with no past history of cardiovascular, renal, hepatic, metabolic or gastrointestinal disease and no past drug allergy participated. The concentration of erythromycin base in venous blood was measured by small plate microbiological assay. Venous blood was taken at zero, 15, 30, 45, 60 min and at 2, 3, 4, 6, 8, 12, 16, 20 and 24 hr after starting the infusions. Duplicate assays were performed on all plasma samples at Guy's and at the manufacturer's laboratories. A full haematological and biochemical screening profile was performed before and after the study. The mean + s.e. plasma erythromycin base concentration rose from 0.7 ± 0'2 jig/ml at 15 min to 6.06 ± 1.6 jg/ml at 1 hr. The peak plasma concentration was between 1.48 ± 0-25 jig/ml at 30 min and 7-21 + 0.93 jig/ml at 4 hr. The plasma concentration at 12 hr was 6.17 + 0.33 pg/ml, and fell to 037 ± 0.05 jtg/ml at 24 hr.These findings suggest that therapeutically effective plasma concentrations follow a slow intravenous infusion of erythromycin lactobionate. There was no evidence of adverse haematological or biochemical function in the tests of blood, hepatic or renal function, apart from two volunteers who vomited after the infusions were discontinued.

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Section: Discussionmentioning

confidence: 99%

Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man

Parsons¹,

Paddock²,

David³

et al. 1978

Postgraduate Medical Journal

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“…Figure 1 shows the clinical appearance of the lipoatrophy in case 1. Skin biopsy samples were taken from the edge of lipoatrophic areas in eight patients (cases 1-8), from the middle of lipoatrophic areas in three (cases 9-11), and from normal skin distant to injection sites in three (cases [12][13][14]. The five control biopsy samples were taken from non-lipoatrophic areas that had recently been repeatedly injected with insulin.…”

Section: Methodsmentioning

confidence: 99%

Adverse reactions to D-penicillamine after gold toxicity.

Dodd¹,

Griffiths²,

Thompson³

1980

BMJ

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Fusidic acid-induced hyperbilirubinemia

et al. 1987

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A 72-year old man developed jaundice while on fusidic acid therapy for suspected osteomyelitis. Hyperbilirubinemia was predominantly of the conjugated variety and elevation in liver enzymes was mild and transient. Although serum bilirubin fell rapidly after fusidic acid was stopped, complete resolution of the hyperbilirubinemia took nearly a month. Other possible causes of jaundice were excluded. Light microscopy of a needle liver biopsy showed focal hepatocyte feathery degeneration, intracellular bile retention, and canalicular bile plugging, most prominent in perivenous regions. Electron microscopy revealed varying degrees of canalicular dilatation, loss of microvilli, and disruption of the canalicular membrane with vesicular bleb formation as well as canalicular bile plugs. Widening of the pericanalicular ectoplasmic zone with accumulation of cytoskeletal filaments was also noted. These findings are similar to those reported in experimental cholestasis induced by bile acids. Possible mechanisms of jaundice caused by fusidic acid are discussed.

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Additives to intravenous fluids.

Abstract: compared with those using the diaphragm when they refer to these two conditions occurring among users of the oral contraceptive ? I would be grateful if this point could be clarified as the text does not do so.

Cited by 5 publications

References 1 publication

Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man

Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man

Adverse reactions to D-penicillamine after gold toxicity.

Fusidic acid-induced hyperbilirubinemia

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