Additively manufactured BaTiO3 composite scaffolds: A novel strategy for load bearing bone tissue engineering applications

Mancuso, Elena; Shah, Lekha; Jindal, Swati; Serenelli, Cecile; Tsikriteas, Zois Michail; Khanbareh, Hamideh

doi:10.1016/j.msec.2021.112192

Cited by 44 publications

(43 citation statements)

References 63 publications

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“…Additionally, the hydroxyapatite nanoparticles are separated to suppress the space–charge polarization among the dipolar moieties of the nanoparticles under an alternating electric field. It is also known as the dielectric confinement effect [ 2 , 23 , 29 , 47 ]. Meanwhile, the H2S8 composite exhibits a higher porosity ( Figure 2 ), which can lead to a significant decrement in the dielectric constant since air voids have a low dielectric constant (ε′ = 1) [ 44 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…This is likely due to excessive starch content and significant porosity of the H2S8 composite. It creates the insulating barriers between the well-dispersed hydroxyapatite nanoparticles and therefore reduces the attenuation of electromagnetic waves [ 2 , 43 , 44 ]. In Figure 5 b,c, it can be found that the tan δ of the porous nHA/S composites tends to increase as the starch proportion increases from 80 to 90 wt%.…”

Section: Resultsmentioning

confidence: 99%

“…In tissue engineering, numerous efforts have been made in research to find alternative materials with similar microstructural features as a natural bone for bone defect reconstruction [ 1 , 2 ]. The microstructural features (pore size, pore distribution, porosity, and pore interconnectivity) of a bone scaffold are the main factors that lead to biological activities (cell adhesion, cell migration, cell proliferation, and cell differentiation) during bone regeneration [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study

You

Cheng

Nasir

et al. 2022

IJMS

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This paper aims to investigate the dielectric properties, i.e., dielectric constant (ε′), dielectric loss factor (ε″), dielectric tangent loss (tan δ), electrical conductivity (σ), and penetration depth (Dp), of the porous nanohydroxyapatite/starch composites in the function of starch proportion, pore size, and porosity over a broad band frequency range of 5 MHz–12 GHz. The porous nanohydroxyapatite/starch composites were fabricated using different starch proportions ranging from 30 to 90 wt%. The results reveal that the dielectric properties and the microstructural features of the porous nanohydroxyapatite/starch composites can be enhanced by the increment in the starch proportion. Nevertheless, the composite with 80 wt% of starch proportion exhibit low dielectric properties (ε′, ε″, tan δ, and σ) and a high penetration depth because of its highly interconnected porous microstructures. The dielectric properties of the porous nanohydroxyapatite/starch composites are highly dependent on starch proportion, average pore size, and porosity. The regression models are developed to express the dielectric properties of the porous nanohydroxyapatite/starch composites (R2 > 0.96) in the function of starch proportion, pore size, and porosity from 1 to 11 GHz. This dielectric study can facilitate the assessment of bone scaffold design in bone tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study

You

Cheng

Nasir

et al. 2022

IJMS

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“…Natural bone is an electricity-generated tissue because of piezoelectric collagen ( Yu et al, 2017 ). Thus, piezoelectric scaffolds are developed to provide electric stimuli for bone regeneration, which include piezoelectric polymers such as PEDOT ( Iandolo et al, 2016 ) and poly (vinylidene fluoride), piezoelectric ceramics such as BaTiO 3 ( Polley et al, 2020 ) and K 0.5 Na 0.5 NbO 3 ( Yu et al, 2017 ), and scaffolds containing piezoelectric particles such as piezoelectric ceramic particles ( Mancuso et al, 2021 ) and nylon-11 nanoparticles ( Ma et al, 2019 )). When piezoelectric scaffolds are subjected to external mechanical stimuli (physiologically or additionally), electric stimuli will be induced for bone regeneration ( Tang et al, 2017 ).…”

Section: Applications Of Biophysical Stimuli For Bone Tissue Engineeringmentioning

confidence: 99%

Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering

Hao

Wang

et al. 2021

Front. Cell Dev. Biol.

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The repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules has several obvious drawbacks. Biophysical stimuli have great potential to become the fourth pillar of bone tissue engineering, which can be categorized into three groups depending on their physical properties: internal structural stimuli, external mechanical stimuli, and electromagnetic stimuli. In this review, distinctive biophysical stimuli coupled with their osteoinductive windows or parameters are initially presented to induce the osteogenesis of mesenchymal stem cells (MSCs). Then, osteoinductive mechanisms of biophysical transduction (a combination of mechanotransduction and electrocoupling) are reviewed to direct the osteogenic differentiation of MSCs. These mechanisms include biophysical sensing, transmission, and regulation. Furthermore, distinctive application strategies of biophysical stimuli are presented for bone tissue engineering, including predesigned biomaterials, tissue-engineered bone grafts, and postoperative biophysical stimuli loading strategies. Finally, ongoing challenges and future perspectives are discussed.

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“…We have also used composite polyε-caprolactone (PCL) scaffolds to mimic the bone tissue (i.e. PCL scaffolds containing inorganic compounds such as hydroxyapatite (HA), strontium HA (SrHA) and barium titanate (BaTiO3) with stiffness and porosity matching the values of trabecular bone 26,27 , being [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] MPa and 35-45% respectively.…”

Section: Introductionmentioning

confidence: 99%

Invasion and secondary site colonization as a function of in vitro primary tumor matrix stiffness

Shah

Latif

Williams

et al. 2022

Preprint

Self Cite

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Increased breast tissue stiffness is correlated with breast cancer risk and invasive cancer progression. However, its role in promoting bone metastasis, which shares a large burden of breast cancer deaths, has not yet been understood. To better understand the cause-effect relationship of tissue stiffness on breast cancer's metastatic potential, we fabricated three-dimensional (3D) models to mimic breast and bone tissue in vitro. Based on our previous work, we used alginate-based hydrogels allowing precise control over stiffness and composition of extracellular breast tissue matrix; and 3D printed poly-ε-caprolactone (PCL)-composite scaffolds to mimic the bone. The latter were further modified by promoting bone-ECM deposition using Saos-2 cells. After a decellularization step, PCL scaffolds were assembled with alginate-gelatin hydrogels and a novel breast-to-bone in vitro model was established. It was observed that increased stiffness of hydrogel resulted in higher migration and invasion capacity of MDA-MB 231 cells. Additionally, PTHrP and IL-6 expression, both of which are implicated in bone metastasis, were higher when cells from stiff hydrogels were cultured in bone/PCL scaffolds. These breast-to-bone in vitro models pose as a novel non-animal technology to pave the way for incorporating important tissue microenvironmental factors of the disease physiology (e.g. tissue stiffness) and emerge as promising future platforms for monitoring metastatic disease phenotypes and therapeutic efficacy.

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Additively manufactured BaTiO3 composite scaffolds: A novel strategy for load bearing bone tissue engineering applications

Cited by 44 publications

References 63 publications

Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study

Regression Analysis of the Dielectric and Morphological Properties for Porous Nanohydroxyapatite/Starch Composites: A Correlative Study

Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering

Invasion and secondary site colonization as a function of in vitro primary tumor matrix stiffness

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