Additive serotonergic genetic sensitivity and cortisol reactivity to lab-based social evaluative stress: Influence of severity across two samples

Vrshek‐Schallhorn, Suzanne; Corneau, Gail M.; Grillo, Alessandra; Sapuram, Vaibhav; Plieger, Thomas; Reuter, Martin

doi:10.1016/j.psyneuen.2022.105767

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…Serotonin, also known as 5hydroxy tryptamine (5-HT), is a monoamine neurotransmitter that regulates a variety of physiological functions and pathological states in the body, such as eating, sleeping, pain and emotions. A recent study found that serotonergic multilocus genetic profile score (MGPS) contributed to sensitivity to social threat, then leading to increased depression (Vrshek-Schallhorn et al, 2022).…”

Section: Effect Of Serotonergic Multilocus On Depressionmentioning

confidence: 99%

Serotonergic multilocus genetic variation moderates the association between interpersonal relationship and adolescent depressive symptoms

Zeng,

Peng,

Liu

et al. 2023

Journal of Affective Disorders

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Section: Effect Of Serotonergic Multilocus On Depressionmentioning

confidence: 99%

Serotonergic multilocus genetic variation moderates the association between interpersonal relationship and adolescent depressive symptoms

Zeng,

Peng,

Liu

et al. 2023

Journal of Affective Disorders

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Polygene by environment interactions predicting depressive outcomes

Grillo

2024

American J of Med Genetics Pt B

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Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene‐by‐environment (G × E) interactions influence depression risk, and further, that depression is polygenic. Thus, recent models have emphasized two polygenic approaches: a hypothesis‐driven multilocus genetic profile score (MGPS; “MGPS × E”) and a polygenic risk score (PRS; “PRS × E”) derived from genome‐wide association studies (GWAS). This review for the first time synthesizes current knowledge on polygene by environment “P × E” interaction research predicting primarily depression‐related outcomes, and in brief, neurobiological outcomes. The “environment” of focus in this project is stressful life events. It further discusses findings in the context of differential susceptibility and diathesis‐stress theories—two major theories guiding G × E work. This synthesis indicates that, within the MGPS literature, polygenic scores based on the serotonin system, the HPA axis, or across multiple systems, interact with environmental stress exposure to predict outcomes at multiple levels of analyses and most consistently align with differential susceptibility theory. Depressive outcomes are the most studied, but neuroendocrine, and neuroimaging findings are observed as well. By contrast, vast methodological differences between GWAS‐based PRS studies contribute to mixed findings that yield inconclusive results.

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Linking individual variability in functional brain connectivity to polygenic risk in major depressive disorder

Hou

Jiang

et al. 2023

Journal of Affective Disorders

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Additive serotonergic genetic sensitivity and cortisol reactivity to lab-based social evaluative stress: Influence of severity across two samples

Cited by 3 publications

References 64 publications

Serotonergic multilocus genetic variation moderates the association between interpersonal relationship and adolescent depressive symptoms

Serotonergic multilocus genetic variation moderates the association between interpersonal relationship and adolescent depressive symptoms

Polygene by environment interactions predicting depressive outcomes

Linking individual variability in functional brain connectivity to polygenic risk in major depressive disorder

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