Additive Manufacturing of Precision Biomaterials

Guzzi, Elia A.; Tibbitt, Mark W.

doi:10.1002/adma.201901994

Cited by 127 publications

(128 citation statements)

References 231 publications

(445 reference statements)

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“…Indeed, developing the ability to pattern and control nanomaterials in a 3D printing process can enable a multiscale, multimaterial additive manufacturing strategy that can create devices and architecture with unprecedented complexity and functional integration, which has a broad and long‐lasting impact on a wide range of fields—from bioprinting25,50,179,418 to space exploration 419–422…”

Section: Discussionmentioning

confidence: 99%

“…A single printer can produce thousands of different designs without molds, dies, or masks. This capability advances the field of medicine with the invention of personalized biomedical devices such as hip replacement implants,134 dental implants,135 ingestible electronics,136–138 and magnetic resonance imaging compatible devices139 that can potentially address significant unmet clinical needs 50,140–142. This also enables the creation of complex 3D geometry for applications in the aerospace143,144 and automotive144 industries, which are otherwise challenging to fabricate and assemble through traditional methods.…”

Section: D Printing Methodsmentioning

confidence: 99%

“…Biological properties : The inclusion of nanomaterials into biocompatible substrates such as hydrogels can enhance bioactivity, and cell viability, of a 3D printed biomaterial 50,51,117. For example, incorporating nanomaterials such as nanosilicates118 and hydroxyapatite nanoparticles52 in hydrogels laced with human mesenchymal cells increases cell viability by up to 80%, increases osteoblast differentiation, and upregulates gene expression.…”

Section: Nanomaterials As Functional and Tunable Building Blocks For mentioning

confidence: 99%

“…The synergistic integration of nanomaterials with additive manufacturing, also known as “3D printing,”25–27 can enable the creation of geometrically complex, functional constructs. The ability to pattern nanomaterials in a 3D printing process can enable the fabrication of multiscale architectures that are seamlessly integrated with functional nanomaterials 28–55. This can be achieved by patterning and guiding the assembly of nanomaterials within a 3D printing process.…”

Section: Introductionmentioning

confidence: 99%

“…Recent advances in 3D printing have demonstrated the multiscale integration of nanomaterials25–27 to enhance mechanical properties29–38,77 and impart optical,39–43 electrical,33,44–47 thermal,37,38 actuation,31,48,49 and biological50–53 properties in 3D printed devices. Further, additional control over the deposition of nanomaterials (via phenomena such as evaporation40,78 and electrical forces33,54,55) can impart anisotropy and heterogeneity in the functional properties of 3D printed constructs.…”

Section: Introductionmentioning

confidence: 99%

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Nanomaterial Patterning in 3D Printing

et al. 2020

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The synergistic integration of nanomaterials with 3D printing technologies can enable the creation of architecture and devices with an unprecedented level of functional integration. In particular, a multiscale 3D printing approach can seamlessly interweave nanomaterials with diverse classes of materials to impart, program, or modulate a wide range of functional properties in an otherwise passive 3D printed object. However, achieving such multiscale integration is challenging as it requires the ability to pattern, organize, or assemble nanomaterials in a 3D printing process. This review highlights the latest advances in the integration of nanomaterials with 3D printing, achieved by leveraging mechanical, electrical, magnetic, optical, or thermal phenomena. Ultimately, it is envisioned that such approaches can enable the creation of multifunctional constructs and devices that cannot be fabricated with conventional manufacturing approaches.

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Section: Discussionmentioning

confidence: 99%

Section: D Printing Methodsmentioning

confidence: 99%

Section: Nanomaterials As Functional and Tunable Building Blocks For mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanomaterial Patterning in 3D Printing

et al. 2020

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Cell‐Instructive Multiphasic Gel‐in‐Gel Materials

Kühn

Sievers

Stoppa

et al. 2020

Adv Funct Materials

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Developing tissue is typically soft, highly hydrated, dynamic, and increasingly heterogeneous matter. Recapitulating such characteristics in engineered cell‐instructive materials holds the promise of maximizing the options to direct tissue formation. Accordingly, progress in the design of multiphasic hydrogel materials is expected to expand the therapeutic capabilities of tissue engineering approaches and the relevance of human 3D in vitro tissue and disease models. Recently pioneered methodologies allow for the creation of multiphasic hydrogel systems suitable to template and guide the dynamic formation of tissue‐ and organ‐specific structures across scales, in vitro and in vivo. The related approaches include the assembly of distinct gel phases, the embedding of gels in other gel materials and the patterning of preformed gel materials. Herein, the capabilities and limitations of the respective methods are summarized and discussed and their potential is highlighted with some selected examples of the recent literature. As the modularity of the related methodologies facilitates combinatorial and individualized solutions, it is envisioned that multiphasic gel‐in‐gel materials will become a versatile morphogenetic toolbox expanding the scope and the power of bioengineering technologies.

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Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Garot

Bettega

Picart

2020

Adv Funct Materials

126

105

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Additive manufacturing (AM) allows the fabrication of customized bone scaffolds in terms of shape, pore size, material type, and mechanical properties. Combined with the possibility to obtain a precise 3D image of the bone defects using computed tomography or magnetic resonance imaging, it is now possible to manufacture implants for patient‐specific bone regeneration. This paper reviews the state‐of‐the‐art of the different materials and AM techniques used for the fabrication of 3D‐printed scaffolds in the field of bone tissue engineering. Their advantages and drawbacks are highlighted. For materials, specific criteria, are extracted from a literature study: biomimetism to native bone, mechanical properties, biodegradability, ability to be imaged (implantation and follow‐up period), histological performances, and sterilization process. AM techniques can be classified in three major categories: extrusion‐based, powder‐based, and vat photopolymerization. Their price, ease of use, and space requirement are analyzed. Different combinations of materials/AM techniques appear to be the most relevant depending on the targeted clinical applications (implantation site, presence of mechanical constraints, temporary or permanent implant). Finally, some barriers impeding the translation to human clinics are identified, notably the sterilization process.

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Additive Manufacturing of Precision Biomaterials

Cited by 127 publications

References 231 publications

Nanomaterial Patterning in 3D Printing

Nanomaterial Patterning in 3D Printing

Cell‐Instructive Multiphasic Gel‐in‐Gel Materials

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

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