Additive manufacturing for bone tissue engineering scaffolds

Qu, Huawei

doi:10.1016/j.mtcomm.2020.101024

Cited by 101 publications

(63 citation statements)

References 109 publications

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“…In SLS technology, the powder materials are heated to partly melt by laser beams instead of completely melting ( Bose et al, 2018 ). Powders with a low melting points are used as binders for bonding high melting point metals ( Qu, 2020 ). Compared with SLS, the laser of SLM has higher energy ( Dogan et al, 2020 ), which can completely melt the powder.…”

Section: Additive Manufacturing Technologymentioning

confidence: 99%

Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review

Wang

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Design an implant similar to the human bone is one of the critical problems in bone tissue engineering. Metal porous scaffolds have good prospects in bone tissue replacement due to their matching elastic modulus, better strength, and biocompatibility. However, traditional processing methods are challenging to fabricate scaffolds with a porous structure, limiting the development of porous scaffolds. With the advancement of additive manufacturing (AM) and computer-aided technologies, the development of porous metal scaffolds also ushers in unprecedented opportunities. In recent years, many new metal materials and innovative design methods are used to fabricate porous scaffolds with excellent mechanical properties and biocompatibility. This article reviews the research progress of porous metal scaffolds, and introduces the AM technologies used in porous metal scaffolds. Then the applications of different metal materials in bone scaffolds are summarized, and the advantages and limitations of various scaffold design methods are discussed. Finally, we look forward to the development prospects of AM in porous metal scaffolds.

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Section: Additive Manufacturing Technologymentioning

confidence: 99%

Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review

Wang

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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“…It is a three-dimensional (3D) porous structure that provides mechanical support for growing cells and developing tissue [ 22 , 23 ]. Importantly, a scaffold should present a series of ideal properties, including: (i) biocompatibility (i.e., support cell activities without any local or systematic toxic effects to the host system); (ii) the ability to mimic the host tissue mechanical properties (e.g., Young’s modulus, compressive strength, tensile strength) to optimize load transfer to the tissue; (iii) tailorable surface properties (e.g., roughness and hydrophilicity); (iv) promoting cell activities, including adhesion, migration, proliferation and differentiation (i.e., being bioactive); (v) providing cells with suitable and extra cellular matrix (ECM)-like cues; (vi) being bioresorbable with tunable degradation kinetics; (vii) integrating properly with the host tissue after implantation; and (viii) being easily processable in a wide variety of shapes and sizes [ 24 ].…”

Section: Tissue Engineering: a Brief Overviewmentioning

confidence: 99%

Molecular Imprinting Strategies for Tissue Engineering Applications: A Review

2021

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Tissue Engineering (TE) represents a promising solution to fabricate engineered constructs able to restore tissue damage after implantation. In the classic TE approach, biomaterials are used alongside growth factors to create a scaffolding structure that supports cells during the construct maturation. A current challenge in TE is the creation of engineered constructs able to mimic the complex microenvironment found in the natural tissue, so as to promote and guide cell migration, proliferation, and differentiation. In this context, the introduction inside the scaffold of molecularly imprinted polymers (MIPs)—synthetic receptors able to reversibly bind to biomolecules—holds great promise to enhance the scaffold-cell interaction. In this review, we analyze the main strategies that have been used for MIP design and fabrication with a particular focus on biomedical research. Furthermore, to highlight the potential of MIPs for scaffold-based TE, we present recent examples on how MIPs have been used in TE to introduce biophysical cues as well as for drug delivery and sequestering.

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“…The material is deposited from a nozzle or syringe to fabricate components in a layer-by-layer manner. These technologies require a liquid or a viscous material that is obtained mainly by two methods, melting a thermoplastic material (FDM) or using a viscous ink (DIW) [ 218 ].…”

Section: Additive Manufacturing Of Bone Tissue-engineered Scaffoldmentioning

confidence: 99%

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

et al. 2020

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Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.

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Additive manufacturing for bone tissue engineering scaffolds

Cited by 101 publications

References 109 publications

Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review

Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review

Molecular Imprinting Strategies for Tissue Engineering Applications: A Review

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

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