Additive effects of resveratrol and doxorubicin on bladder cancer cells

Soares, Luciana Bicalho Moreira; Lima, Ana Paula Braga; Melo, André Sacramento; Almeida, Tamires Cunha; Teixeira, Luiz Fernando; Silva, Glenda Nicioli da

doi:10.1097/cad.0000000000001218

Cited by 8 publications

(6 citation statements)

References 30 publications

(42 reference statements)

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“…kidney diseases, and hypertension (Singh et al, 2019). In addition to the mentioned diseases, RSV anticancer effects have been widely studied in cancers of the prostate, colorectal, cervix, breast, lung, bladder, and ovary (Chen et al, 2022;Li, Fan, et al, 2022;Nadile et al, 2022;Soares et al, 2022;Sun, Zhou, et al, 2019;Vernousfaderani et al, 2021;Zaffaroni & Beretta, 2021). Among the versatile properties of RSV, its anti-aging effects and protective roles against age-related diseases have attracted a lot of attention recently.…”

Section: Resveratrol and Its Beneficial Effectsmentioning

confidence: 99%

“…Studies have indicated the therapeutic role of RSV in several diseases and conditions, including but not limited to diabetes mellitus, metabolic syndrome, cardiovascular diseases, rhinopharyngitis, Alzheimer's disease, stroke, Parkinson's disease, kidney diseases, and hypertension (Singh et al, 2019). In addition to the mentioned diseases, RSV anticancer effects have been widely studied in cancers of the prostate, colorectal, cervix, breast, lung, bladder, and ovary (Chen et al, 2022; Li, Fan, et al, 2022; Nadile et al, 2022; Soares et al, 2022; Sun, Zhou, et al, 2019; Vernousfaderani et al, 2021; Zaffaroni & Beretta, 2021). Among the versatile properties of RSV, its anti‐aging effects and protective roles against age‐related diseases have attracted a lot of attention recently.…”

Section: Resveratrol and Its Beneficial Effectsmentioning

confidence: 99%

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Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Zhang,

Kiarasi

2024

Phytotherapy Research

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Recently, various studies have shown that epigenetic changes are associated with aging and age‐related diseases. Both animal and human models have revealed that epigenetic processes are involved in aging mechanisms. These processes happen at multiple levels and include histone modification, DNA methylation, and changes in noncoding RNA expression. Consequently, changes in the organization of chromatin and DNA accessibility lead to the regulation of gene expression. With increasing awareness of the pivotal function of epigenetics in the aging process, researchers' attention has been drawn to how these epigenetic changes can be modified to prevent, stop, or reverse aging, senescence, and age‐related diseases. Among various agents that can affect epigenetic, polyphenols are well‐known phytochemicals found in fruits, vegetables, and plants. Polyphenols are found to modify epigenetic‐related mechanisms in various diseases and conditions, such as metabolic disorders, obesity, neurodegenerative diseases, cancer, and cardiovascular diseases. Resveratrol (RSV) is a member of the stilbene subgroup of polyphenols which is derived from various plants, such as grapes, apples, and blueberries. Therefore, herein, we aim to summarize how RSV affects different epigenetic processes to change aging‐related mechanisms. Furthermore, we discuss its roles in age‐related diseases, such as Alzheimer's, Parkinson's, osteoporosis, and cardiovascular diseases.

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Section: Resveratrol and Its Beneficial Effectsmentioning

confidence: 99%

Section: Resveratrol and Its Beneficial Effectsmentioning

confidence: 99%

Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Zhang,

Kiarasi

2024

Phytotherapy Research

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“…16 Cisresveratrol is unstable and commercially unavailable; however, transresveratrol (also called resveratrol) is relatively stable and exhibits broad anti-inflammatory, anticancer, antioxidative, and antiobesity activities. 17,18 Resveratrol has been reported to exhibit growthinhibitory effects in various human cancers, including breast, 19,20 bladder, 21,22 prostate, 23,24 colon, 25,26 and ovarian 27,28 cancers. In addition, resveratrol significantly decreased the incidence of esophagitis.…”

Section: Introductionmentioning

confidence: 99%

Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Song,

Qu,

Jia

et al. 2024

Molecular Carcinogenesis

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The worldwide incidence and mortality rates of esophageal squamous cell carcinoma (ESCC) have increased over the last decade. Moreover, molecular targets that may benefit the therapeutics of patients with ESCC have not been fully characterized. Our study discovered that thousand and one amino‐acid protein kinase 1 (TAOK1) is highly expressed in ESCC tumor tissues and cell lines. Knock‐down of TAOK1 suppresses ESCC cell proliferation in vitro and patient‐derived xenograft or cell‐derived xenograft tumors growth in vivo. Moreover, TAOK1 overexpression promotes ESCC growth in vitro and in vivo. Additionally, we identified that the natural small molecular compound resveratrol binds to TAOK1 directly and diminishes the kinase activity of TAOK1. Targeting TAOK1 directly with resveratrol significantly inhibits cell proliferation, induces cell cycle arrest and apoptosis, and suppresses tumor growth in ESCC. Furthermore, the silencing of TAOK1 or the application of resveratrol attenuated the activation of TAOK1 downstream signaling effectors. Interestingly, combining resveratrol with paclitaxel, cisplatin, or 5‐fluorouracil synergistically enhanced their therapeutic effects against ESCC. In conclusion, this work illustrates the underlying oncogenic function of TAOK1 and provides a theoretical basis for the application of targeting TAOK1 therapy to the clinical treatment of ESCC.

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“…Accumulated evidence of RES also refers to therapeutic benefit for many kinds of cancer. The combination of low concentration DOX and RES could show the additive effect on antitumor activity on bladder cancer cells when compared to RES or DOX alone [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells

Yahayo,

Pongkittiphan,

Supabphol

et al. 2024

Asian Pac J Cancer Prev

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Objectives: This research aims to comparatively investigate the capability of resveratrol (RES) and RES analogues, oxyresveratrol (Oxy-RES) and dihydrooxyresveratrol (DHoxy-RES), to potentiate doxorubicin (DOX) effects against lung carcinoma epithelial cells. Methods: All experiments were performed on lung carcinoma cell lines (A549) with DOX combination between DOX and RES or RES analogues. Cell viability or growth inhibitory effect was assessed by MTT assay and genes associated with survival and metastasis were monitored by real-time polymerase chain reaction (RT-PCR). Results: DOX obviously demonstrated cytotoxic and anti-metastatic activities against A549 cells. Expression of gene-associated with both activities was potentiated by RES and RES analogues. Oxy-RES showed highest capability to potentiate DOX effects. DHoxy-RES showed nearly no effect to DOX activities. Conclusions: These results provided an important basis of DOX combination with RES analogues, especially Oxy-RES, for better therapeutic effect. Further studies in human should be performed on exploring combination of DOX and Oxy-RES.

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Additive effects of resveratrol and doxorubicin on bladder cancer cells

Abstract: migration, cell morphology and nuclear division index (NDI) assays using bladder cancer cell lines. Methods Cell lines

Cited by 8 publications

References 30 publications

Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells

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