Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle

Br, Choi; Kumar, Sandeep; Zhao, Chen; Lt, Zhang; Cy, Kim; Sw, Lee; Jh, Jeon; So, Insuk; Sh, Kim; Nc, Park; Hk, Kum; Jk, Park

doi:10.1038/ijir.2015.23

Cited by 10 publications

(7 citation statements)

References 38 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we notice a highly significant increase (p < 0.01) in relative weight of ovary in G3 and G4; and significant increase (p < 0.05) in G1 compared to the control. We also observed not statistically [7] proved that the supplementation of oleic acid induces production of prostaglandin in maternal endometrial and Choi B R et al (2015) [8] reported that the perfusion with scopoletin lead to significant increase in cyclic adenosine monophosphate. It is well known that the gonadotropins FSH and LH act on their target cells via their specific membrane receptors, respectively FSHR and LHR.…”

Section: Evolution Of Organs Weightmentioning

confidence: 63%

Effect of organic extracts of <i>Bunium incrassatum</i> on the hematological, ovarian and uterine parameters of mature female rabbit

Chentouh¹,

Boulahbel²,

Ouldjaoui³

et al. 2017

J. Fundam and Appl Sci.

View full text Add to dashboard Cite

This work aims to evaluate the effect of the organic extracts of Bunium incrassatum roots on some hematological parameters and histological changes of the genital tract. The study was achieved on mature rabbits of the local breed for 15 days. The animals were divided into five groups, which have daily administered 0, 25, 50, 100 and 200 mg/kg/day doses, respectively.The group with dose 0 was taken as a control. After treatment, the rabbits were sacrificed. The rabbit blood was collected in heparin tubes and their ovaries and uterus were removed, fixed in 10 % formalin; and stained with hematoxylin-eosin. The treatment induces a significant decrease in the level of Triglyceride, Cholesterol and a significant increase in the number of growing follicles accompanied by a decrease in atretic follicles, compared to the control group. The study shows that the organic extract of B. Incrassatum has estrogenic effects.

show abstract

Section: Evolution Of Organs Weightmentioning

confidence: 63%

Effect of organic extracts of <i>Bunium incrassatum</i> on the hematological, ovarian and uterine parameters of mature female rabbit

Chentouh¹,

Boulahbel²,

Ouldjaoui³

et al. 2017

J. Fundam and Appl Sci.

View full text Add to dashboard Cite

show abstract

“…Of the phytochemical constituents determined in leaves and stems of J. macrantha ethyl acetate fraction, some of them have demonstrated to ameliorate the ED in experimental animals. Scopoletin showed a positive effect in penile erection of rats through the NO-cGMP and adenylyl cAMP-PKA signaling pathways [ 25 ]. Vitexin at doses of 40 mg/kg regulated some endocrine hormones and had an improving in the fertility rate sex performance in diabetic mice, the mechanism involved might be in the modulation of hypothalamus–pituitary–gonadal axis [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats

et al. 2021

View full text Add to dashboard Cite

Jatropha macrantha Müll Arg. L is also known as “huanarpo macho” and used in the Peruvian traditional medicine as an aphrodisiac and erectile dysfunction (ED). The aim of this study was to determine the phytochemical constituents in leaves and stems ethyl acetate fraction (LEAF and SEAF) of J. macrantha and to compare the antioxidant activity and the ameliorative effect on ketamine-induced erectile dysfunction in rats. The phytochemical constituents were determined by LC-ESI-MS/MS, the total phenolic compounds and total flavonoids (TPC and TF) by Folin-Ciocalteu and aluminum chloride, respectively. The antioxidant activity was determined by DPPH, ABTS, and FRAP assays. Experimental groups were divided as follows: I: negative control; II: positive control (ketamine at 50 mg/ kg/d); III: sildenafil 5 mg/kg; IV, V, VI: LEAF at 25, 50 and 100 mg/kg, respectively, and VII, VIII, IX: SEAF at 25, 50, and 100 mg/kg, respectively. The phytochemical analysis revealed the presence mainly of coumarins, flavonoids, phenolic acids, and terpenes. TPC of LEAF and SEAF were 359 ± 5.21 mg GAE/g and 306 ± 1.93 mg GAE/g, respectively; TF in LEAF and SEAF were 23.7 ± 0.80 mg EQ/g, and 101 ± 1.42 mg EQ/g, respectively. The DPPH, ABTS, FRAP in SEAF were 647 ± 3.27; 668 ± 2.30; and 575 ± 2.86 μmol TE/g, respectively, whilst LEAF showed 796 ± 3.15; 679 ± 0.85; and 806 ± 3.42 μmol TE/g, respectively. Regarding sexual behavior, LEAF showed a better effect in mount frequency, intromission frequency, ejaculation frequency, mount latency, intromission latency, ejaculatory latency, and post ejaculatory latency than SEAF. As conclusion, LEAF of J. macrantha at 50 mg/kg showed a better effect on sexual behavior in male rats with erectile dysfunction than SEAF but not higher than sildenafil.

show abstract

“…PCCSM tension was measured as described previously [ 17 ]. Briefly, each rabbit PCCSM strip was mounted and equilibrated for 60 min, with an adjustment of the stretch level to a resting tension of 1 g. Then, PE (10 −5 M) was added to adjust the maximum contractile tension.…”

Section: Methodsmentioning

confidence: 99%

Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway

Karna

Choi

Kim

et al. 2022

JCM

View full text Add to dashboard Cite

The present study was designed to evaluate the relaxation effect of Rubus occidentalis (RO) and ellagic acid (EA) on rabbit penile corpus cavernosum smooth muscle (PCCSM). Rabbit PCCSM was treated with ROE or EA after preincubation with nitric oxide synthase (NOS), guanylate cyclase (GC), adenylyl cyclase (AC) or protein kinase A (PKA) blocker. Cyclic nucleotides in the perfusate were analyzed using radioimmunoassay (RIA). Subsequently, perfused PCCSMs were subjected to analysis to evaluate the expression level of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS). The interaction of ROE or EA with phosphodiesterase (PDE) 5 and PDE4 inhibitors, such as udenafil (UDE) and rolipram (ROL), were also evaluated. Both ROE and EA relaxed the PCCSM in a concentration-dependent manner. Coincubation of ROE or EA with NOS, GC, AC, or PKA blocker significantly decreased the ROE- and EA-induced relaxation. Pretreatment of ROE and EA significantly upregulated the cyclic guanosine monophosphate (cGMP), cyclic adenosine 3′,5′-monophosphate (cAMP), and eNOS levels in the perfused PCCSM. Furthermore, the treatment of ROE and EA markedly increased the UDE- and ROL-induced relaxation of the PCCSM. In conclusion, ROE and EA induced PCCSM relaxation by activating the nitric oxide (NO)-cGMp and cAMp signaling pathways and may have a synergistic action to improve erectile function.

show abstract

Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle

Cited by 10 publications

References 38 publications

Effect of organic extracts of <i>Bunium incrassatum</i> on the hematological, ovarian and uterine parameters of mature female rabbit

Effect of organic extracts of <i>Bunium incrassatum</i> on the hematological, ovarian and uterine parameters of mature female rabbit

Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats

Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway

Contact Info

Product

Resources

About