Additive effect of interleukin-6 and C-reactive protein (CRP) single nucleotide polymorphism on serum CRP concentration and other cardiovascular risk factors

Paik, Jean Kyung; Kim, Oh Yoen; Koh, Soo Jeong; Jang, Yangsoo; Chae, Jey Sook; Kim, Ji Young; Kim, Hyae Jin; Hyun, Young-Min; Cho, Jung Rae; Lee, Jong Ho

doi:10.1016/j.cca.2006.11.011

Cited by 35 publications

(35 citation statements)

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“…The associations still existed significantly after adjusting for potential confounding factors, including age, cigarette smoking, alcohol drinking and puberty status. Paik et al 17 observed a combined effect of the IL-6 gene and CRP gene polymorphisms on CRP concentration. The subjects having both the high-risk IL-6 genotype and the variant allele of the CRP gene showed the highest CRP levels.…”

Section: Discussionmentioning

confidence: 99%

“…6 Some studies mention that the IL-6R gene variants are significantly associated with plasma CRP levels, 29 and that the CRP gene and IL-6 gene have a combined effect on CRP levels and insulin resistance variables (insulin levels and homeostasis model assessment for insulin resistance) in adults. 17 It is possible that the CRP gene and the IL-6R gene have a combined effect on obesity status or other metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The CRP and IL-6 genes had an additive effect on CRP concentration and other cardiovascular disease risk factors in subjects who carried both the minor IL-6 genotype and variant alleles of the CRP gene. 17 To our knowledge, the relationship between genetic variation in the CRP gene or IL-6R gene and obesity has rarely been investigated in Asian populations, and particularly in Asian children. Therefore, the aim of this study was to evaluate the effect of the CRP þ 2147 A/G (rs1205) and IL-6R rs2229238 polymorphisms on the anthropometric characteristics of Taiwanese school children.…”

Section: Introductionmentioning

confidence: 99%

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Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

Lin

Chu

et al. 2010

Int J Obes

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

Lin

Chu

et al. 2010

Int J Obes

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“…IL-6 production by infected adipocytes JJM Bouwman et al portal circulation may lead to increased production of CRP by the liver and influence lipid metabolism leading to an increased cardiovascular risk 40,41 and increased risk for the development of type 2 diabetes. 42,43 The inflammatory response of adipocytes upon infection may also have paracrine effects by affecting the function of neighboring adipocytes and may attract macrophages into adipose tissue, increasing the capacity for the production of inflammatory mediators.…”

Section: Discussionmentioning

confidence: 99%

Infection-induced inflammatory response of adipocytes in vitro

et al. 2008

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Background: Abdominal obesity plays an important role in the development of insulin resistance, diabetes mellitus and atherosclerosis. The exact pathophysiological mechanisms are unclear but adipocyte dysfunction is thought to be crucial. Infections are associated with the development of atherosclerosis as well as diabetes. In this study we investigated whether adipocytes can be infected and whether this results in production of inflammatory cytokines relevant for the development of atherosclerosis and diabetes. Methods: Pre-adipocytes were cultured and differentiated into mature adipocytes in vitro. Adipocytes and pre-adipocytes were incubated with infective and heat-inactivated Chlamydia pneumoniae, cytomegalovirus (CMV), adenovirus (Ad) subtypes 2 and 36, influenza A and respiratory syncitial virus (RSV). After 48 h, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and plasminogen activator inhibitor-1 (PAI-1) were measured in supernatants. Results: Infection of adipocytes with Ad-36, CMV and RSV resulted in increased IL-6 production from 192 ± 22 pg ml À1 (uninfected) to 1030 ± 86 pg ml À1 , 838 ± 59 pg ml À1 and 1241 ± 191 pg ml À1 , respectively (all Po0.01 vs control). In addition, Ad-36 infection slightly reduced PAI production in adipocytes (285 ± 26.8 ng ml À1 vs uninfected: 477 ± 71.2 ng ml À1 ; P ¼ 0.05) and pre-adipocytes (709±43.3 ng ml À1 vs uninfected: 1071±71.8 ng ml À1 ; Po0.01). In contrast, human Ad type 2 did not exert any effect on IL-6 or PAI production. None of the microorganisms induced significant changes in adiponectin and/or TNF-a production. Conclusions: Adipocytes can be infected with several microorganisms in vitro. Infection of adipocytes with Ad-36, but not Ad-2 leads to increased production of IL-6 which might contribute to chronic low-grade inflammation, a process known to be involved in the development of cardiovascular diseases and type 2 diabetes.

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“…Significant increments in CRP concentrations in individuals carrying the -717G allele in the acute phase of stroke were found when compared with the baseline state [23]. Other authors did not observe any effect of the above-mentioned SNP on CRP level [19,20,24,25]. The association of this SNP with myocardial infarct and coronary heart disease (CHD) supports the belief that carriers of the -717A allele of the CRP gene are genetically predisposed to CHD [26].…”

Section: Introductionmentioning

confidence: 87%

The effects of simvastatin on the C-reactive protein level and lipid profile in the acute phase of ischaemic stroke in relation to -717A>G CRP gene polymorphism

Kotlęga

Białecka

Kurzawski

et al. 2017

Pomeranian J Life Sci

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Wstęp: Patogeneza i ryzyko wystąpienia udaru niedokrwiennego mózgu związane są z obecnością zmian zapalnych biorących udział w rozwoju miażdżycy. Powszechnie stosowanym wykładnikiem procesu zapalnego jest stężenie białka C-reaktywnego (CRP) w surowicy. Poziom CRP wykorzystuje się w ocenie ryzyka wystąpienia i rokowania w chorobach sercowo-naczyniowych oraz w udarze. Stężenie CRP podlega wpływom czynników genetycznych, takich jak polimorfizm genetyczny, oraz środowiskowym, wśród których znajduje się stosowanie statyn. Celem pracy było ustalenie potencjalnego wpływu simwastatyny na stężenie CRP i profil lipidowy w udarze z uwzględnieniem wariantu polimorfizmu -717A>G genu CRP.Materiały i metody: Do badania włączono 125 chorych hospitalizowanych z powodu udaru niedokrwiennego mózgu. Na podstawie kryteriów włączenia i wyłączenia do I grupy zakwalifikowano 95, a do grupy II – 30 chorych. Pacjenci z grupy I otrzymywali simwastatynę wdawce 40 mg od 1. doby, natomiast w grupie II nie stosowano tego leczenia. U wszystkich chorych oznaczono stężenie CRP i profil lipidowy w 1. i 10. dobie hospitalizacji oraz oznaczono wariant polimorfizmu -717A>G genu CRP.Wyniki: W grupie I i II odnotowano istotny wzrost stężenia CRP, pomimo leczenia simwastatyną. U osób w grupie I i II nie stwierdzono istotnego wpływu poszczególnych wariantów polimorfizmu -717A>G genu CRP na zmianę stężenia CRP i profilu lipidowego pomiędzy 1. a10. dobą hospitalizacji.Wnioski: Simwastatyna nie wpływa na stężenie CRP w ostrej fazie udaru mózgu w zależności od jakiegokolwiek wariantu polimorfizmu -717A>G genu CRP. Zastosowanie simwastatyny w ostrej fazie udaru niedokrwiennego mózgu wyraźnie wpływa na profil lipidowy, przy czym efekt nie jest zależny od wariantów polimorfizmu -717A>G genu CRP.

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Additive effect of interleukin-6 and C-reactive protein (CRP) single nucleotide polymorphism on serum CRP concentration and other cardiovascular risk factors

Cited by 35 publications

References 39 publications

Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

Infection-induced inflammatory response of adipocytes in vitro

The effects of simvastatin on the C-reactive protein level and lipid profile in the acute phase of ischaemic stroke in relation to -717A>G CRP gene polymorphism

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