Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

Lin, Fen; Chu, Nain-Feng; Ch, Lee; Yj, Hung; Dm, Wu

doi:10.1038/ijo.2010.195

Cited by 7 publications

(7 citation statements)

References 46 publications

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“…Directly between the above two clusters, lies rs7740975 (2.2 X 10 −5 p-value for association in present study), which is intronic to solute carrier family 35 member F1 ( SLC35F1 ), a member of the SLC35 family of transporters which aid in the formation of glycoproteins in the Golgi apparatus and endoplasmic reticulum [85]. Variants of this member of the solute carrier gene family have been associated with a number of cardiovascular disease phenotypes related to hypertension [86], congestive heart failure [87], obesity [88], heart rate [89], and electrocardiographic QT interval [90], as have some polymorphisms of the CRP gene [17,91–93]. Of note, the gene G protein-coupled receptor class C group 6 member A ( GPRC6A ) is only 500 Kb distal to this SNP and has demonstrated effects on CRP levels [21].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, two studies using Mendelian randomization approaches to assess the influence of inherited increases in CRP level on the risk for colorectal cancer, supported a causal relationship between increased CRP and cancer [14,15]. Evidence for a genetic influence on the relationship between immune factors, metabolic syndrome and cardiovascular risk factors is provided by the association of alleles increasing CRP levels and increased risk of obesity [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study

et al. 2019

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BackgroundIncreased serum levels of C-reactive protein (CRP), an important component of the innate immune response, are associated with increased risk of cardiovascular disease (CVD). Multiple single nucleotide polymorphisms (SNP) have been identified which are associated with CRP levels, and Mendelian randomization studies have shown a positive association between SNPs increasing CRP expression and risk of colon cancer (but thus far not CVD). The effects of individual genetic variants often interact with the genetic background of a population and hence we sought to resolve the genetic determinants of serum CRP in a number of American Indian populations.MethodsThe Strong Heart Family Study (SHFS) has serum CRP measurements from 2428 tribal members, recruited as large families from three regions of the United States. Microsatellite markers and MetaboChip defined SNP genotypes were incorporated into variance components, decomposition-based linkage and association analyses.ResultsCRP levels exhibited significant heritability (h2 = 0.33 ± 0.05, p<1.3 X 10−20). A locus on chromosome (chr) 6, near marker D6S281 (approximately at 169.6 Mb, GRCh38/hg38) showed suggestive linkage (LOD = 1.9) to CRP levels. No individual SNPs were found associated with CRP levels after Bonferroni adjustment for multiple testing (threshold <7.77 x 10−7), however, we found nominal associations, many of which replicate previous findings at the CRP, HNF1A and 7 other loci. In addition, we report association of 46 SNPs located at 7 novel loci on chromosomes 2, 5, 6(2 loci), 9, 10 and 17, with an average of 15.3 Kb between SNPs and all with p-values less than 7.2 X 10−4.ConclusionIn agreement with evidence from other populations, these data show CRP serum levels are under considerable genetic influence; and include loci, such as near CRP and other genes, that replicate results from other ethnic groups. These findings also suggest possible novel loci on chr 6 and other chromosomes that warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study

et al. 2019

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“…The sampling method and results have been previously described [25]. Briefly, the survey included junior high school students in Taipei City to collect a representative distribution of demographic, lifestyle, and biochemical characteristics to measure their risk for cardiovascular disease.…”

Section: Methodsmentioning

confidence: 99%

Effect ofGAS6andAXLGene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

Hsiao

Lin

Hsieh

et al. 2014

International Journal of Endocrinology

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The present study was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents' GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, and AXL rs2304232 polymorphisms. Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype of GAS6 rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of AXL rs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of AXL rs4802113. Boys with both the GG genotype of GAS6 rs8191973 and the GG genotype of GAS6 rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of the GAS6 rs8191973 and the A allele of the GAS6 rs8191974. In conclusion, GAS6 and AXL polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys.

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“…The sampling method and results have been described elsewhere (29). In brief, this survey was administered to junior high school students in Taipei to collect a representative distribution of demographic, lifestyle, and biochemical characteristics to measure their risk for cardiovascular disease.…”

Section: Study Design and Samplingmentioning

confidence: 99%