“…According to the inclusion criteria of each trial, patients were required to have adequate hepatic, renal and hematological function. Underlying malignancies included colorectal cancer (eleven trials) [14,15,[22][23][24][25][26][27][28][29][30][31], non-small-cell lung cancer (seven trials) [32][33][34][35][36][37][38], head and neck cancer (four trials) [5,13,39,40], breast cancer (one trial) [41], urothelial carcinoma (one trial) [42], pancreatic cancer (one trial) [43] and esophagogastric cancer (one trial) [44].…”