Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature

Hechtman, Jaclyn F.; DeMatteo, Ronald P.; Nafa, Khédoudja; Chi, Ping; Arcila, Maria E.; Doğan, Snjezana; Oultache, Alifya; Chen, Wen; Hameed, Meera

doi:10.1245/s10434-014-4332-z

Cited by 48 publications

(46 citation statements)

References 22 publications

(23 reference statements)

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“…Firstly, it adds evidence to the existing literature suggesting that patients diagnosed with a GIST are at an increased risk of developing an additional malignancy. The incidence of additional malignancies in this series was 10.6%, in keeping with the rates reported in other series that have scrutinized this association, which range from 4.5 to 42.0% …”

Section: Discussionsupporting

confidence: 89%

The impact of additional malignancies in patients diagnosed with gastrointestinal stromal tumors

Smith

Mahar

et al. 2016

Intl Journal of Cancer

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A higher incidence of additional malignancies has been described in patients diagnosed with gastrointestinal stromal tumors (GIST). This study aimed to identify risk factors for developing additional malignancies in patients diagnosed with GIST and evaluate the impact on survival. Individuals diagnosed with GIST from 2001 to2009 were identified from the SEER database. Logistic regression was used to identify predictors of additional malignancies and Cox‐proportional hazards regression used to identify predictors of survival. In the study period, 1705 cases of GIST were identified, with 181 (10.6%) patients developing additional malignancies. Colorectal cancer was the most common cancer developing within 6 months of GIST diagnosis (30%). The median time to diagnosis of a malignancy after 6 months of GIST diagnosis was 21.9 months. Older age (p < 0.0001) and extraoesophagogastric GIST (p = 0.0027) were significant prognostic factors associated with additional malignancies. The overall 5‐year survival was 65%, with the presence of additional malignancies within 6 months of GIST diagnosis associated with poor overall survival (54%, HR 1.55 1.05–2.3 95% CI, p = 0.04). Predictive factors of additional malignancies in patients diagnosed with GIST are increasing age and the primary disease site. Developing additional malignancies within 6 months of GIST diagnosis is associated with poorer overall survival. Targeted surveillance may be warranted in patients diagnosed with GIST that are at high risk of developing additional malignancies.

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Section: Discussionsupporting

confidence: 89%

The impact of additional malignancies in patients diagnosed with gastrointestinal stromal tumors

Smith

Mahar

et al. 2016

Intl Journal of Cancer

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“…In particular, the presence of multiple or double cancers influences the selection and results of treatment modalities for oral cancer (16,18,23,24). In the present study, ~10% of all patients developed multiple cancers, including oral cancer.…”

Section: Discussionmentioning

confidence: 49%

Clinical features of multiple primary carcinomas of the oral cavity

Li¹,

Ma²,

Han³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to elucidate the clinical characteristics of multiple primary carcinomas of the oral cavity. The clinical records of 1,024 patients who were treated during follow-up for oral cancer at the Department of Stomatology, Henan Provincial People's Hospital, between March 2013 and December 2014 were retrospectively reviewed. The clinical characteristics of 961 patients who developed single primary oral squamous cell carcinoma (SCC) during follow-up and 54 patients who subsequently developed multiple primary carcinomas in the oral cavity were compared. Multiple primary carcinomas exhibited a female predilection, were most prevalent in the gingiva, and tended to show earlier tumor and nodal stages, as compared with single primary carcinomas. The local recurrence rate was higher for multiple primary carcinomas, as compared with single primary carcinomas, and was demonstrated to increase with the number of multiple primary occurrences. The cumulative incidence rates for metachronous second primary carcinomas following the onset of the first carcinoma at 10 years was 8.0%. Recurrence of multiple primary carcinomas did not decrease the survival rates of the patients assessed in the present study. Furthermore, differences were detected in the clinical characteristics between patients with single oral SCC and those with multiple primary oral carcinomas. The results of the present study indicated that early diagnosis and treatment and close long-term follow-up are required for patients with multiple primary oral carcinomas.

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“…[5,12–15] A previous meta-analysis reviewed 14 literatures and demonstrated that approximately 9.2% of GIST patients suffered a second primary carcinoma. Among these synchronous cancers, GI malignancies account for 4.7% (228/4813) of GIST patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and prognosis of coexistence of gastric gastrointestinal stromal tumor and gastric cancer

Liu

Liu²,

Zheng³

et al. 2016

Medicine

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The coexistence of gastric gastrointestinal stromal tumor (GIST) and gastric cancer is relatively high, and its prognosis is controversial due to the complex and variant kinds of presentation. Thus, the present study aimed to explore the clinicopathological features and prognostic factors of gastric GIST with synchronous gastric cancer.From May 2010 to November 2015, a total of 241 gastric GIST patients were retrospectively enrolled in the present study. The patients with coexistence of gastric GIST and gastric cancer were recorded. The clinicopathological features and prognoses of patients were analyzed.Among 241 patients, 24 patients had synchronous gastric cancer (synchronous group) and 217 patients did not (no-synchronous group). The synchronous group presented a higher percentage of elders (66.7% vs 39.6%, P = 0.001) and males (87.5% vs 48.4%, P < 0.001) than the no-synchronous group. The tumor diameter, mitotic index, and National Institutes of Health degree were also significantly different between the 2 groups (all P < 0.05). The 5-year disease-free survival and disease-specific survival rates of synchronous group were significantly lower than those of no-synchronous group (54.9% vs 93.5%, P < 0.001; 37.9% vs 89.9%, P < 0.001, respectively). However, the 5-year overall survival rates between synchronous and gastric cancer groups were comparable (37.9% vs 57.6%, P = 0.474).The coexistence of gastric GIST and gastric cancer was common in elder male patients. The synchronous GIST was common in low-risk category. The prognosis of gastric GIST with synchronous gastric cancer was worse than that of primary-single gastric GIST, but was comparable with primary-single gastric cancer.

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Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature

Cited by 48 publications

References 22 publications

The impact of additional malignancies in patients diagnosed with gastrointestinal stromal tumors

The impact of additional malignancies in patients diagnosed with gastrointestinal stromal tumors

Clinical features of multiple primary carcinomas of the oral cavity

Clinicopathological features and prognosis of coexistence of gastric gastrointestinal stromal tumor and gastric cancer

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