Clinicopathological features and prognosis of coexistence of gastric gastrointestinal stromal tumor and gastric cancer

Abstract

The coexistence of gastric gastrointestinal stromal tumor (GIST) and gastric cancer is relatively high, and its prognosis is controversial due to the complex and variant kinds of presentation. Thus, the present study aimed to explore the clinicopathological features and prognostic factors of gastric GIST with synchronous gastric cancer.From May 2010 to November 2015, a total of 241 gastric GIST patients were retrospectively enrolled in the present study. The patients with coexistence of gastric GIST and gastric cancer were recorded. The clinicopathological features and prognoses of patients were analyzed.Among 241 patients, 24 patients had synchronous gastric cancer (synchronous group) and 217 patients did not (no-synchronous group). The synchronous group presented a higher percentage of elders (66.7% vs 39.6%, P = 0.001) and males (87.5% vs 48.4%, P < 0.001) than the no-synchronous group. The tumor diameter, mitotic index, and National Institutes of Health degree were also significantly different between the 2 groups (all P < 0.05). The 5-year disease-free survival and disease-specific survival rates of synchronous group were significantly lower than those of no-synchronous group (54.9% vs 93.5%, P < 0.001; 37.9% vs 89.9%, P < 0.001, respectively). However, the 5-year overall survival rates between synchronous and gastric cancer groups were comparable (37.9% vs 57.6%, P = 0.474).The coexistence of gastric GIST and gastric cancer was common in elder male patients. The synchronous GIST was common in low-risk category. The prognosis of gastric GIST with synchronous gastric cancer was worse than that of primary-single gastric GIST, but was comparable with primary-single gastric cancer.

Early gastric cancer with three gastric gastrointestinal stromal tumors combined with synchronous colon cancer: A case report

“…GIST is diagnosed with an endoscope or computed tomography, and although the treatment may be slightly different depending on the place or size of the tumor, the treatment of choice is surgical resection. There have been several cases in which gastric GIST was found simultaneously with gastric cancer [12,13]. In addition, the mechanism of multiple GISTs has not yet been clari ed, but several studies have been reported previously [14,15].…”

Early gastric cancer with three gastric gastrointestinal stromal tumors combined with synchronous colon cancer: a case report

“…GIST is diagnosed via endoscopy or computed tomography, and although the treatment may be slightly different depending on the location or size of the tumor, the treatment of choice is surgical resection. There have been several cases in which gastric GIST was found simultaneously with gastric cancer [ 13 , 14 ]. Moreover, although several studies have reported on multiple GISTs [ 15 , 16 ], the exact mechanism of their occurrence remains to be elucidated.…”

Significance of Primary Malignant Tumors on the Outcome of Patients With Resected Gastrointestinal Stromal Tumors

“…A report demonstrated that GISTs were present with high frequency (35%) in the resected stomach of patients with gastric cancer (19). The size of GIST malignancies simultaneously resected with other malignancies tended to be small and the grade low (20). Therefore, pathological examination of surgical specimens from gastric cancer surgery may find GIST and increase the number of patients with GIST.…”