Additional evidence for the anti-inflammatory and anti-allergic properties of the sesquiterpene polygodial

Cunha, Fernanda Marques da; Fröde, Tânia Sílvia; Mendes, Gilboé L.; Malheiros, Ângela; Filho, Valdir Cechinel; Yunes, Rosendo A.; Calixto, João B.

doi:10.1016/s0024-3205(01)01387-x

Cited by 74 publications

(54 citation statements)

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“…15 Many studies have reported the therapeutic properties of this compound, including its anti-bacterial, 26 anti-fungal, [27][28][29] anti-hyperalgesia, 30 anti-inflammatory, anti-allergic and vasorelaxation activities. 31 Several studies have also reported protozoal growth inhibitory activity for polygodial and its derivatives. Potent growth inhibition was reported for polygodial isolated from Drimysbra siliensis against Leishmania spp.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Rayan¹,

Matthews²,

Donnell³

et al. 2016

Phcogj

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Background: Giardiasis is a debilitating disease caused by gastrointestinal parasites of the genus Giardia. Tasmannia lanceolata (Tasmanian pepper berry) has a high anti-oxidant capacity and has documented therapeutic properties for a variety of pathogenic diseases. Materials and methods: Solvent extracts of T. lanceolata berry and leaf were investigated for the ability to block G. duodenalis growth. The IC 50 values of the extracts which displayed inhibitory activity were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Active extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in crude plant extracts. Results: Methanolic, aqueous and ethyl acetate T. lanceolata berry and leaf extracts displayed potent G. duodenalis growth inhibitory activity. The methanolic extracts were the most potent growth inhibitors with IC 50 values of approximately 180 µg/ml and 420 µg/ml for the berry and leaf methanolic extracts respectively. The aqueous, ethyl acetate, chloroform and hexane extracts also inhibited G. duodenalis growth, albeit with lower potency. HPLC-QTOF mass spectroscopy analysis of the extracts

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Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Rayan¹,

Matthews²,

Donnell³

et al. 2016

Phcogj

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show abstract

“…Suppression of chemically induced paw edema in mice is a long-standing assay for assessment of an agent's potential anti-inflammatory activity [33][34][35][36][37][38][39]32 . In prior studies, several cannabinoids 40 and a number of NSAIDs tested in this model exhibited inhibitory effects on chemically induced edema.…”

Section: Anti-inflammatory Effects In Vivomentioning

confidence: 99%

Potential anti-inflammatory actions of the elmiric (lipoamino) acids

Burstein

Adams²,

Bradshaw

et al. 2007

Bioorganic & Medicinal Chemistry

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A library of amino acid-fatty acid conjugates (elmiric acids) was synthesized and evaluated for activity as potential anti-inflammatory agents. The compounds were tested in vitro for their effects on cell proliferation and prostaglandin production and compared with their effects on in vivo models of inflammation. LPS stimulated RAW 267.4 mouse macrophage cells was the in vitro model and phorbol ester-induced mouse ear edema served as the principal in vivo model. The prostaglandin responses were found to be strongly dependent on the nature of the fatty acid part of the molecule. Polyunsaturated acid conjugates produced a marked increase in media levels of i15-deoxy-PGJ 2 with minimal effects on PGE production. It is reported in the literature that prostaglandin ratios in which the J series predominates over the E series promote the resolution of inflammatory conditions. Several of the elmiric acids tested here produced such favorable ratios suggesting that their potential antiinflammatory activity occurs via a novel mechanism of action. The ear edema assay results were generally in agreement with the prostaglandin assay findings indicating a connection between them.

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“…and after an adaptation period of 15 min, 10 m L of capsaicin (1.6 mg/ ear) was applied under the skin of the surface of the right ear (14). After 15 min, the animals were observed individually and the increase of ear volume was considered indicative of edema.…”

Section: Capsaicin-induced Edema Assaymentioning

confidence: 99%

Bulgarian Propolis Induces Analgesic and Anti-inflammatory Effects in Mice and Inhibits In Vitro Contraction of Airway Smooth Muscle

et al. 2003

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Abstract. Propolis is a bee product, which has long been used in folk medicine for the management of different diseases. In this study we evaluated the analgesic and anti-inflammatory effects of a standard ethanolic extract of Bulgarian propolis (Et-Blg) in mice and its in vitro effect on airway smooth muscle. Et-Blg inhibited acetic acid-induced abdominal contortions with an ID 50 = 7.4 ± 0.7 mg × kg -1 . In the formalin test, the extract caused a significant reduction in pain in mice treated with 100 mg × kg -1 Et-Blg during the neurogenic phase and for the inflammatory phase with all doses of the extract, with an ID 50 = 2.5 ± 0.4 mg × kg -1 . Et-Blg inhibited also the capsaicin-induced ear edema in mice; however, this extract was ineffective when assessed in the tail-flick and hot-plate thermal assays. The analgesic effect of Et-Blg was associated with the inhibition of inflammatory responses and not to a simple irritation of nervous terminals. In vitro, this extract inhibited the contraction of trachea smooth muscle induced by histamine (IC 50 = 50 ± 5 mg × mL -1 ), capsaicin (IC 50 = 26.8 ± 3 m g × mL -1), 80 mM KCl (IC 50 = 27.8 ± 3 mg × mL -1 ), and carbachol (IC 50 = 54 ± 2 mg × mL -1 ).

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Additional evidence for the anti-inflammatory and anti-allergic properties of the sesquiterpene polygodial

Cited by 74 publications

References 0 publications

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Potential anti-inflammatory actions of the elmiric (lipoamino) acids

Bulgarian Propolis Induces Analgesic and Anti-inflammatory Effects in Mice and Inhibits In Vitro Contraction of Airway Smooth Muscle

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