Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: First report of a potential combination therapy

Anil, Sukumaran; Allan, Ernest; Allan, Donald; Colthurst, James; Bayat, Ardeshir

doi:10.1016/j.jdermsci.2011.08.012

Cited by 25 publications

(21 citation statements)

References 40 publications

(33 reference statements)

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“…Electro stimulation was suggested as combined or adjuvant treatment. 44,87 Keloid surgical excision must be done carefully, because the risk of recurrence is great, 44,88 and excision can widen scars and lead to larger keloids in the case of recurrence. 44,89 Intralesional steroid injections after excision are recommended.…”

Section: Keloid Scarsmentioning

confidence: 99%

Characteristics of Asian skin–revision

Lym

Azevedo

Cohen

et al. 2018

JDC

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Asians are a group with various skin phototypes, ranging from Fitzpatrick classification type III and IV in Chinese and Japanese populations and type IV and V in Indian and Pakistani populations. Asian skin tends to present post-inflammatory hyperpigmentation, melasma, lentigines and freckles, and nevi of Ota and Hori nevi. The main skin diseases reported include acne, atopic dermatitis and viral infections. Wrinkles and skin thickness are early signs of ageing in Caucasians but are less evident in Asian skin. Nevertheless, pigmentary changes occur earlier. The aim of this study is to show the importance of studying the characteristics of Asian skin in order to achieve better management of skin diseases in this population group that is increasingly common in the clinic. Based on a broad review of the literature, we report the characteristics of Asian skin, as well as some dyschromias and common skin disorders in this ethnic group.

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Section: Keloid Scarsmentioning

confidence: 99%

Characteristics of Asian skin–revision

Lym

Azevedo

Cohen

et al. 2018

JDC

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“…There are a variety of treatment options for scars, and each is associated with various benefits, safety profiles, adverse events, and financial and time considerations, so a significant effort is put toward developing more‐efficacious treatment options with minimal risk profile. A few clinical observations and small studies have illustrated the beneficial effects of red LLLT, with and without adjunctive agents, in the treatment of scars . We believe that LLLT generated using LEDs holds promise as a noninvasive treatment for scars.…”

mentioning

confidence: 94%

“…A few clinical observations and small studies have illustrated the beneficial effects of red LLLT, with and without adjunctive agents, in the treatment of scars. [9][10][11] We believe that LLLT generated using LEDs holds promise as a noninvasive treatment for scars. This approach has many clinical advantages over other scar therapeutics: it is typically painless, is inexpensive, can cover large treatment areas at a time, does not require highly trained personnel, and is portable, allowing for patient home use.…”

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confidence: 99%

Inhibition of Fibroblast Proliferation In Vitro Using Red Light-Emitting Diodes

Lev‐Tov¹,

Mamalis

Brody

et al. 2013

Dermatologic Surgery

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“…2 Recently, a few clinical observations and small studies have revealed the possible benefit of red and infrared (IR) low-level light therapy (LLLT), with and without adjunctive agents, to improve scars. [3][4][5][6] There is a lack of basic scientific data in dermatology that demonstrate inhibition of fibroblast proliferation and modulation of other cellular characteristics of keloid scars induced by LEDs. LLLT is based on the principle that heme-copper photoacceptors within the cytochrome C component of the electron transport chain can be photo-stimulated or photo-inhibited, leading to modulation of cellular properties.…”

mentioning

confidence: 99%

Inhibition of Fibroblast Proliferation In Vitro Using Low-Level Infrared Light-Emitting Diodes

Lev‐Tov

Brody

Siegel

et al. 2013

Dermatologic Surgery

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BACKGROUND Scars, including hypertrophic and keloidal-type scars, may occur after burns, trauma, or surgery. Despite several treatment options available for scars, few effective, noninvasive modalities exist.Recently, a few small clinical studies revealed the possible benefit of red and infrared (IR) low-level light therapy (LLLT) in scar treatment. One of the important features of scars is proliferation of dermal fibroblasts, but in vitro data regarding the effects of light-emitting diode (LED)-generated IR light on human skin fibroblasts is lacking.OBJECTIVE To evaluate the effect of IR LLLT generated using LEDs on fibroblast proliferation and viability in vitro.METHODS AND MATERIALS Irradiation of normal human skin fibroblasts using IR LED panels was performed in vitro, and modulation of proliferation and viability was quantified using Trypan blue dye exclusion assay.RESULTS Fluences of 80, 160 and 320 J/cm 2 resulted in statistically significantly less fibroblast proliferation than in controls, without statistically significantly less cellular viability.CONCLUSION IR LLLT can effectively inhibit fibroblast proliferation in vitro without altering viability and holds promise for the treatment of scars.

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Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: First report of a potential combination therapy

Cited by 25 publications

References 40 publications

Characteristics of Asian skin–revision

Characteristics of Asian skin–revision

Inhibition of Fibroblast Proliferation In Vitro Using Red Light-Emitting Diodes

Inhibition of Fibroblast Proliferation In Vitro Using Low-Level Infrared Light-Emitting Diodes

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