Addition conjuguée d'amines primaires aux composés acryliques α-(1-hydroxy)alkylés : Nouvelles synthèses de β-et de γ-lactames polyfonctionnels

Metal catalyst-free N-allylation/alkylation of imidazole and benzimidazole with Morita–Baylis–Hillman (MBH) alcohols and acetates

“…Alternatively, we also investigated the reaction of alcohol 1a [ 38 ] and imidazole ( 2a , 2 equiv), without any catalyst or additive in refluxing methanol, a solvent commonly employed in the conversion of MBH adducts using a variety of amines [ 39 – 40 ]. Our study showed that the imidazole ( 2a ) reacted with alcohol 1a , without any additive or in the presence of DABCO as additive, in a 1,4-fashion leading to the imidazole derivative 8a , within 10 h in 65–68% yield ( Table 2 , entries 5 and 6).…”

Stereocontrolled conjugate additions to dihydroindolizinone systems. Synthesis of enantiopure polysubstituted tetrahydropyrrolo[2,1-a]isoquinolones

“…C 24 H 35 NO 5 : calcd C 69.04,H 8.45,N 3.35;found C 68.99,H 8.37,N 3.41 13.8, 19.1, 23.2, 27.5, 28.9, 30.5, 37.4, 43.6, 43.0, 55.7, 56.1, 57.5, 65.6, 67.4, 108.9, 111.3, 127.3, 127.9, 147.6, 147.7, 168.1, 170.2. LRMS (EI, 70 eV): m/z (%)¼417 (M þ , 2), 361 (24), 360 (100), 286 (32), 258 (16), 244 (11), 230 (4), 214 (3), 200 (3), 57 (6). C 24 H 35 NO 5 : calcd C 69.04,H 8.45,N 3.35;found C 68.85,H 8.28,N 3.48.…”

“…LRMS (EI, 70 eV): m/z (%)¼417 (M þ , 2), 361 (24), 360 (100), 286 (37), 260 (8), 259 (10), 258 (19), 244 (11), 200 (3), 91 (3), 57 (8). C 24 H 35 NO 5 : calcd C 69.04,H 8.45,N 3.35;found C 68.99,H 8.37,N 3.41 13.8, 19.1, 23.2, 27.5, 28.9, 30.5, 37.4, 43.6, 43.0, 55.7, 56.1, 57.5, 65.6, 67.4, 108.9, 111.3, 127.3, 127.9, 147.6, 147.7, 168.1, 170.2.…”

Catalysis by hydroxyapatite alone and modified by sodium nitrate: a simple and efficient procedure for the construction of carbon-nitrogen bonds in heterogeneous catalysis

“…2 This condensation is normally carried out in the presence of a Lewis acid, 3 although, in same cases the reaction occurs with no special activation, 4 in others stronger reaction conditions are required. 5 Of late there has been interest in carrying out synthetic organic reactions under conditions which do not require separation of the product from other organic materials (such as the base), which are fast, effective, and which do not require heating or the use of large quantities of solvent.…”