Adding Ipsilateral V20 and V30 to Conventional Dosimetric Constraints Predicts Radiation Pneumonitis in Stage IIIA–B NSCLC Treated With Combined-Modality Therapy

Ramella, Sara; Trodella, Lucio; Mineo, Tommaso Claudio; Pompeo, Eugenio; Stimato, Gerardina; Gaudino, Diego; Valentini, Vincenzo; Cellini, Francesco; Ciresa, M.; Fiore, Michele; Piermattei, Angelo; Russo, Patrizia; Cesario, Alfredo; D’Angelillo, Rolando Maria

doi:10.1016/j.ijrobp.2009.01.036

Cited by 76 publications

(62 citation statements)

References 21 publications

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“…At the same time, it was shown that there is a high correlation of the decrease in the percentage of FEV1 and V20, (r=0.49, P=0.032). Our observations confirm V20 as a significant factor of predisposition for the manifestation of RP in accordance with relevant publications (Claude et al, 2005;Piotrowski et al, 2005;Kong et al, 2006;Uno et al, 2006;Schallenkamp et al, 2007;Ramella et al, 2010;Kimura et al, 2012;Kumar et al, 2012).…”

Section: Discussionsupporting

confidence: 93%

Suggestion for a New Grading Scale for Radiation Induced Pneumonitis Based on Radiological Findings of Computerized Tomography: Correlation with Clinical and Radiotherapeutic Parameters in Lung Cancer Patients

Kouloulias

Zygogianni²,

Efstathopoulos³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: The objective of this research is the computed axial tomography (CT) imaging grading of radiation induced pneumonitis (RP) and its correlation with clinical and radiotherapeutic parameters. Materials and Methods: The chest CT films of 20 patients with non-small cell lung cancer who have undergone threedimensional conformal radiation therapy were reviewed. The proposed CT grading of RP is supported on solely radiological diagnosis criteria and distinguishes five grades. The manifestation of RP was also correlated with any positive pre-existing chronic obstructive pulmonary disease (COPD) history, smoking history, the FEV1 value, and the dosimetric variable V20. Results: The CT grading of RP was as follows: 3 patients (15%) presented with ground glass opacity (grade 1), 9 patients (45%) were classified as grade 2, 7 patients (35%) presented with focal consolidation, with or without elements of fibrosis (grade 3), and only one patient (5%) presented with opacity with accompanying atelectasis and loss of pulmonary volume (grade 4). Both univariate and multivariate analysis revealed as prognostic factors for the radiological grading of RP the reduction of FEV1 and the V20 (P=0.026 and P=0.003, respectively). There was also a significant (P<0.001) correlation of radiological grading of RP with FEV1 and V20 (spearman rho 0.92 and 0.93, respectively). Conclusions: The high correlation of the proposed radiological grading with the FEV1 and the V20 is giving a satisfactory clinical validity. Although the proposed grading scale seems relevant to clinical practice, further studies are needed for the confirmation of its validity and reliability.

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Section: Discussionsupporting

confidence: 93%

Suggestion for a New Grading Scale for Radiation Induced Pneumonitis Based on Radiological Findings of Computerized Tomography: Correlation with Clinical and Radiotherapeutic Parameters in Lung Cancer Patients

Kouloulias

Zygogianni²,

Efstathopoulos³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Poor performance status and pulmonary function, lower-lobe location of primary lung tumor, use of chemotherapy (especially concurrent chemoradiation), high radiation dose, elevated dose-rate, largely treated volume, and elevated levels of plasma transforming-growth factor beta (TGFb1) have all been associated with the subsequent development and/or severity of RP. Recently, lung dose-volume histogram (DVH) parameters generated from 3D CT plans have been investigated for their ability to predict the development of RP (9,19,20,22,26).…”

Section: Discussionmentioning

confidence: 99%

A Clinical Score, Including Biohumoral Parameters, Is a Useful Pretest Index to Discriminate Pulmonary Infections from Radiation Damage in Chemoradiation-Treated Lung Cancer Patients

Ramella¹,

Spoto

Fiore³

et al. 2014

Cancer Investigation

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To obtain an easy and prompt differential diagnosis between lower airways infections and acute radiation pneumonitis in chemoradiation lung cancer patients. From 303 patients treated, only patients with severe pulmonary symptoms were hospitalized. Clinical and radiation scores were calculated evaluating clinical, biohumoral, dosimetric parameters. Out of 36 patients hospitalized, infections and acute radiation pneumonitis were reported in 66.7% and 33.3%, respectively. Patients with clinical score ≥ 2 had an Odds Ratio of 3.4 (1.4-8.3; p = .006) to have infectious pneumonia, while radiation score was not predictive.

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“…While some studies excluded GTV from the lung volume, others excluded PTV from the lung volume (Rancati et al, 2003;Schallenkamp et al, 2007;Ramella et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Radiation Pneumonia Development Risk in Lung Cancer Cases

Yılmaz¹,

Adaş²,

Hiçsönmez³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Adding Ipsilateral V20 and V30 to Conventional Dosimetric Constraints Predicts Radiation Pneumonitis in Stage IIIA–B NSCLC Treated With Combined-Modality Therapy

Cited by 76 publications

References 21 publications

Suggestion for a New Grading Scale for Radiation Induced Pneumonitis Based on Radiological Findings of Computerized Tomography: Correlation with Clinical and Radiotherapeutic Parameters in Lung Cancer Patients

Suggestion for a New Grading Scale for Radiation Induced Pneumonitis Based on Radiological Findings of Computerized Tomography: Correlation with Clinical and Radiotherapeutic Parameters in Lung Cancer Patients

A Clinical Score, Including Biohumoral Parameters, Is a Useful Pretest Index to Discriminate Pulmonary Infections from Radiation Damage in Chemoradiation-Treated Lung Cancer Patients

Evaluation of the Radiation Pneumonia Development Risk in Lung Cancer Cases

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