Evaluation of the Radiation Pneumonia Development Risk in Lung Cancer Cases

Yılmaz, Sercan; Adaş, Yasemin Güzle; Hiçsönmez, A; Andrieu, Meltem Nalca; Akyürek, Serap; Gökçe, Şaban Çakır

doi:10.7314/apjcp.2014.15.17.7371

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…According to reports, the incidence of acute radioactive lung injury is 5% to 37%. Approximately 10% to 20% of non-small-cell lung cancer (NSCLC) patients developed severe lung toxicity after thoracic irradiation, and about 1.6% of these patients died from RP (18)(19)(20)(21) . In this study, the incidence of RP was 27.9% and the incidence of grade 3 RP was about 9.6%, which consistent with reported results.…”

Section: Discussionmentioning

confidence: 99%

Predictive values of TNF-α, IL-6, IL-10 for radiation pneumonitis

Li¹,

Chen²,

Lü

et al. 2016

IJRR

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Background:To inves gate the expression of TNF-α, IL-6, IL-10 in the plasma of pa ents with lung cancer who received radia on therapy (RT), and to analyze the correla on between these cytokines and radia on pneumoni s (RP). Materials and Methods: Pa ents with lung cancer who received 3D-CRT in our hospital were prospec vely evaluated. Circula ng cytokine levels were measured with ELISA before RT and at the end of RT. Regular follow-up was undertaken 3 months a1er RT. Sta s cal analysis was applied to determine the relevance of cytokines to radia on-induced lung injury. Results: Of 104 pa ents, 29 (27.9%) developed RP. The levels of TNF-α and IL -6 levels in the plasma a1er RT were significantly higher than before RT (p<0.05), whereas IL -10 levels were significantly lower a1er RT than before RT (p<0.05). Before RT, TNF-α levels were higher in RP group (p<0.05),but there were no differences in TNF-α levels a1er RT. No associa on was observed between IL-6 and IL-10 levels and the risk of RP. Univariate analysis showed that baseline pulmonary func on, smoking history, histopathology, lung volume receiving ≥20 Gy (V20), Mean lung dose (MLD) and total radia on dose were related to RP, but only MLD was an independent risk factor for RP in lung cancer pa ents (OR>1). Conclusion: TNF-α levels in plasma were closely related to RP but s ll cannot be used as predictors for RP.

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Section: Discussionmentioning

confidence: 99%

Predictive values of TNF-α, IL-6, IL-10 for radiation pneumonitis

Li¹,

Chen²,

Lü

et al. 2016

IJRR

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“…Late pneumonia occurs approximately 6 months after the end of thoracic radiotherapy, as a result of a continuous process from acute pneumonitis that stabilizes approximately 2 years after the end of treatment . In exceptional cases, it could have an adverse progression to acute respiratory distress syndrome or bronchiolitis obliterans with organizing pneumonia …”

Section: Discussionmentioning

confidence: 99%

“…17 In exceptional cases, it could have an adverse progression to acute respiratory distress syndrome or bronchiolitis obliterans with organizing pneumonia. 18 Chest radiography detects the acute pneumonitis in about 50% of the cases, showing reminiscent images of confluent alveolar and interstitial infiltrates in the irradiated field. 16 Chest computed tomography scan is the most sensitive method for acute pneumonitis diagnoses, but it is expensive, less specific, creates additional radiation exposure, and is not feasible for screening; thus, the diagnosis of acute pneumonitis is only performed in presence of clinical deterioration.…”

Section: Discussionmentioning

confidence: 99%

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The Potential Role of Lung Ultrasound B‐Lines for Detection of Lung Radio‐Induced Toxicity in Breast Cancer Patients after Radiation Therapy

Petruzzelli

Vasti²,

Tramacere

et al. 2016

Echocardiography

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“…Radiation pneumonia is usually observed in the early stage, and then develops into radiation-induced pulmonary fibrosis in the late-stage. 3 , 4 …”

Section: Introductionmentioning

confidence: 99%

Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROS/MYPT1/TGFβ1 Signaling Via miR-19b-3p

Zhang

Liu

et al. 2020

Dose-Response

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The mechanism of pulmonary fibrosis caused by irradiation remains obscure. Since rosmarinic acid (RA) have anti-oxidant and anti-inflammatory properties, we aimed to evaluate the effect of RA on the X-ray-induced lung injury. Male rats received RA (30, 60, or 120 mg/kg) 7 days before 15 Gy of X-ray irradiation. Here, we showed that RA reduced X-ray-induced the expression of inflammatory related factors, and the level of reactive oxygen species. RA down-regulated the phosphorylation of nuclear factor kappa-B (NF-κB). We found that thoracic tumor patients whose lung regions received radiation showed lower level of microRNA-19b-3p (miR-19b-3p). Furthermore, we provided evidence that miR-19b-3p targets myosin phosphatase target subunit 1 (MYPT1), and RA attenuated RhoA/Rock signaling through upregulating miR-19b-3p, leading to the inhibition of fibrosis. In conclusion, RA may be an effective agent to relieve the pulmonary fibrosis caused by radiotherapy of thoracic tumor.

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Evaluation of the Radiation Pneumonia Development Risk in Lung Cancer Cases

Cited by 9 publications

References 16 publications

Predictive values of TNF-α, IL-6, IL-10 for radiation pneumonitis

Predictive values of TNF-α, IL-6, IL-10 for radiation pneumonitis

The Potential Role of Lung Ultrasound B‐Lines for Detection of Lung Radio‐Induced Toxicity in Breast Cancer Patients after Radiation Therapy

Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROS/MYPT1/TGFβ1 Signaling Via miR-19b-3p

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