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“…It should be noted that although statistically significant reductions in the pain scores were noted in all surgical procedures in this meta-analysis, the magnitude of effect is relatively small. For example, in Bafna et al, 26 Balaban et al, 44 Aydogan et al, 72 Eskandar and Ebeid, 51 and Lee et al, 55 statistically significant decreases in pain scores at 2 hours postsurgery were reported, although the standard difference in mean pain scores between pregabalin and the control group was only <1 point on the VAS pain score. Studies on clinically significant decreases in VAS/NRS pain scores have demonstrated that an average decrease in pain score of at least 1.80 points on NRS scores or 1.3 to 2.8 points on VAS pain scores are required for the decrease to be considered clinically meaningful.…”
Section: Discussionmentioning
“…Aydogan et al [10] studied 60 patients who were candidate for percutaneous nephrolytetomy showed that analgesic effects of a single dose of 75 mg of pregabalin in the prevention of postoperative pain in 30 minutes and 1 and 2 hours after surgery was effective. Aydogan et al [10] stated that VAS is used to assess the severity of pain after surgery. In this study, single dose of pregabalin decreased rate of postoperative sore throat in the intervention group, although this reduction was not statistically significant (P=0.45).…”
Section: Discussionmentioning
“…Many studies showed that pregabalin has analgesic effects which are used at doses of 300 mg up to 1,200 mg in separated doses or with other analgesics before the onset of pain [8][9]. Pregabalins, strong connection to the Delta α² shows that by reducing the depolarization-induced calcium influx at nerve terminals induction and consequently decrease of the number of stimulatory mediators, such as glutamate, norepinephrine, substance P and calcitonin generelated peptide (CGRP) happens [10]. It is probable that this modulation of neurotransmitter released by pregabalin contributes to the drug's anticonvulsant, analgesic, and anxiolytic effects [9][10].…”
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