“…The present demonstration of similar effects of HIV/AIDS and FH on frontal P300 area is consistent with other reports documenting susceptibility of the frontal brain to HIV-1 (Bauer and Shanley, 2006;Chang et al, 2003;Cloak et al, 2004;Wu et al, 2006), a family history of alcoholism (Bauer and Hesselbrock, 2002;Schweinsburg et al, 2004), and attendant factors--e.g., Conduct Disorder/Antisocial Personality Disorder (Bauer and Houston, 2004;Bauer and Shanley, 2006;Bauer and Hesselbrock, 2001;Hoptman, 2003;Nakano et al, 2006;Raine et al, 2000;Yang et al, 2005)--which increase the risk for both HIV/AIDS (e.g., Brooner et al, 1993;Erbelding et al, 2004) and substance abuse/dependence (e.g., Hesselbrock et al, 1985;McGovern et al, 2006). The demonstration of an interaction between HIV/AIDS and FH also raises interesting questions regarding genetic vulnerability to neurocognitive impairment in HIV/AIDS.…”