Addiction, compulsive drug seeking, and the role of frontostriatal mechanisms in regulating inhibitory control

Feil, Jodie; Sheppard, Dianne Melinda; Fitzgerald, Paul B.; Yücel, Murat; Lubman, Dan I.; Bradshaw, John L.

doi:10.1016/j.neubiorev.2010.03.001

Cited by 298 publications

(222 citation statements)

References 187 publications

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“…This is consistent with a previous report of naltrexone enhancing frontal engagement during a temporal discounting task in alcohol-dependent and control subjects (Boettiger et al, 2009), presumably reflecting greater fronto-striatal control over impulsive behavior (Courtney et al, 2013;Feil et al, 2010). Further, the development of pharmacotherapies that target and rescue deficient processes underlying the drug craving state, such as prefrontal cortical function, has been advanced as a promising strategy in treatment development (Sinha, 2013).…”

Section: Discussionsupporting

confidence: 89%

The Effects of Pharmacological Opioid Blockade on Neural Measures of Drug Cue-Reactivity in Humans

Courtney

Ghahremani

Ray

2016

Neuropsychopharmacol

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Interactions between dopaminergic and opioidergic systems have been implicated in the reinforcing properties of drugs of abuse. The present study investigated the effects of opioid blockade, via naltrexone, on functional magnetic resonance imaging (fMRI) measures during methamphetamine cue-reactivity to elucidate the role of endogenous opioids in the neural systems underlying drug craving. To investigate this question, non-treatment seeking individuals with methamphetamine use disorder (N = 23; 74% male, mean age = 34.70 (SD = 8.95)) were recruited for a randomized, placebo controlled, within-subject design and underwent a visual methamphetamine cue-reactivity task during two blood-oxygen-level dependent (BOLD) fMRI sessions following 3 days of naltrexone (50 mg) and matched time for placebo. fMRI analyses tested naltrexone-induced differences in BOLD activation and functional connectivity during cue processing. The results showed that naltrexone administration reduced cue-reactivity in sensorimotor regions and related to altered functional connectivity of dorsal striatum, ventral tegmental area, and precuneus with frontal, visual, sensory, and motor-related regions. Naltrexone also weakened the associations between subjective craving and precuneus functional connectivity with sensorimotor regions and strengthened the associations between subjective craving and dorsal striatum and precuneus connectivity with frontal regions. In conclusion, this study provides the first evidence that opioidergic blockade alters neural responses to drug cues in humans with methamphetamine addiction and suggests that naltrexone may be reducing drug cue salience by decreasing the involvement of sensorimotor regions and by engaging greater frontal regulation over salience attribution.

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Section: Discussionsupporting

confidence: 89%

The Effects of Pharmacological Opioid Blockade on Neural Measures of Drug Cue-Reactivity in Humans

Courtney

Ghahremani

Ray

2016

Neuropsychopharmacol

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“…Alterations in the orbital frontal cortex increase the salience of drugs and drug-related cues (Nutt, Lingford-Hughes, and Nestor, 2012). Alterations in the dorsolateral prefrontal cortex and in the anterior cingulate gyrus narrow the focus of attention so that fewer options are considered (Garavan et al, 2007;Feil et al, 2010). In addition, changes in the dopamine system alter the incentive value not merely of drugs but of a large variety of cues related to drugs.…”

Section: IIImentioning

confidence: 99%

Addiction, Autonomy, and Informed Consent: On and Off the Garden Path

Levy

2015

JMPHIL

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“…While the dependence profile of the classes of addictive drugs varies somewhat (FernandezSerrano et al, 2011), research in recent decades suggests that the neurochemical adaptations and neural circuitry underlying the addictive process is remarkably similar across abused substances (Feil et al, 2010;Robinson & Berridge, 2003;Volkow et al, 2011). This chapter will review research implicating the prefrontal cortex and executive abilities for each major class of addictive drugs (Psychostimulants, Opioids, Alcohol, and Nicotine).…”

mentioning

confidence: 98%

“…The prefrontal cortex represents a complex and heterogeneous structure with multiple subregions interacting with various subcortical circuits (Feil et al, 2010;Tekin & Cummings, 2002). The functions of the prefrontal cortex have been broadly characterized as executive functions.…”

mentioning

confidence: 99%

“…(Conner et al, 2010). Drug addicts show impaired executive function and decreased activity in the prefrontal cortex (Dom et al, 2005;Feil et al, 2010). Several prospective studies suggest lower scores on measures of executive abilities among adolescents is predictive of future vulnerability to drug dependence suggesting executive dysfunction is among the variables conferring vulnerability for drug addiction (Mezzich et al, 2007;Najam et al, 1997).…”

mentioning

confidence: 99%

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