Addenbrooke’s Cognitive Examination validation in Parkinson’s disease

Reyes, Mathew; Lloret, Santiago Pérez; Gerscovich, E. R.; Martín, María; Leiguarda, R; Merello, Marcelo

doi:10.1111/j.1468-1331.2008.02384.x

Cited by 78 publications

(70 citation statements)

References 38 publications

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“…Total scores range from 0-100, a higher score indicates better functioning. The ACE-R has demonstrated reliability in a PD population (Reyes et al, 2009). …”

Section: Cognition 10mentioning

confidence: 99%

Thinking positively about chronic illness: An exploration of optimism, illness perceptions and well‐being in patients with Parkinson's disease

Hurt

Burn

Hindle

et al. 2013

British J Health Psychol

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This is the unspecified version of the paper.This version of the publication may differ from the final published version. Holding positive beliefs about illness and having an optimistic outlook has been associated with increased well-being across a range of health conditions. However research has indicated that being very optimistic may not actually be beneficial and holding a realistic attitude is more adaptive in some forms of chronic illness, e.g. Parkinson's disease (PD). The present study aimed to explore the nature of relationships between illness perceptions, optimism and well-being; specifically whether a linear or non-linear relationship best described the data. Additionally the proposed moderating effect of optimism on the relationship between illness perceptions and well-being was tested. Permanent repository linkDesign 109 participants with idiopathic PD completed questionnaire measures of illness perception, optimism, mood and health-related quality of life (HRQoL). MethodsMultiple regression analyses were used to explore relationships between illness perceptions, optimism, mood and HRQoL. The potential curvilinear effects of illness perceptions and optimism were modelled using squared variables and linear and quadratic curve estimation. Results 4Holding positive illness perceptions predicted better well-being. Some evidence for a non-linear relationship between optimism and mood was found. Optimism had a significant moderating effect on the relationship between specific illness perceptions and outcome. ConclusionsOptimism appears to provide protection against some negative perceptions of illness and was associated with better mood and HRQoL. The findings indicate which specific illness perceptions may be beneficial targets for therapy. Therapeutic interventions should focus on enhancing positive perceptions of PD but potentially more importantly general optimistic attitude to maximise wellbeing.

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“…Total scores range from 0-100, a higher score indicates better functioning. The ACE-R has demonstrated reliability in a PD population (Reyes et al, 2009). …”

Section: Cognition 10mentioning

confidence: 99%

Thinking positively about chronic illness: An exploration of optimism, illness perceptions and well‐being in patients with Parkinson's disease

Hurt

Burn

Hindle

et al. 2013

British J Health Psychol

View full text Add to dashboard Cite

show abstract

“…The ACE-R, designed to be a more thorough cognitive screening tool than the MMSE, includes six subscores evaluating orientation, attention, memory, verbal fluency, language and visuospatial functioning. The ACE-R has high sensitivity and specificity for the diagnosis of dementia in PD using a cutoff score of 83 [Reyes et al 2009], and more recent work has shown it to be a highly useful screen for the diagnosis of MCI in PD using a cutoff score of 89 [McColgan et al 2012]. Moreover, performance on aspects of the ACE-R, particularly the verbal fluency subscore, has been shown to inform the differential diagnosis of Parkinsonian syndromes including PD, PSP and corticobasal degeneration (CBD) [Rittman et al 2013].…”

Section: Implications For Patient Care: Assessment and Counselingmentioning

confidence: 99%

The cognitive side of essential tremor: what are the therapeutic implications?

Janicki

Cosentino

Louis

2013

Ther Adv Neurol Disord

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While essential tremor (ET) has traditionally been categorized as a pure motor disease, cross-sectional and longitudinal studies of cognition in ET have demonstrated that these patients may have cognitive dysfunction. Recent epidemiological studies demonstrate an association between ET (particularly with onset after age 65) and increased risk for cognitive impairment and dementia. Although existing studies have generally conceptualized cognitive changes in ET as consistent with a 'frontosubcortical' or 'corticocerebellar' profile, results from these same studies suggest that cognitive impairment in ET may in fact be heterogeneous. Furthermore, the underlying mechanisms remain uncertain. Cognitive changes could be a byproduct of the cerebellar dysfunction of ET itself; alternately, they may be a feature of concomitant neurodegenerative diseases that have been associated in several studies with ET, including Alzheimer's disease, Parkinson's disease or progressive supranuclear palsy. While the study of cognitive dysfunction in ET has received research attention in recent years, the results of these studies have not been translated into the clinical domain and clinical practice. This review first summarizes the current literature on the potential relationships between ET and cognitive change. We then suggest areas of further clinical evaluation and treatment; these suggestions are directed at physicians caring for ET patients who may demonstrate or complain of cognitive impairment. As we discuss, clinicians should ideally screen ET patients for possible signs or symptoms of cognitive impairment in addition to assessing for psychiatric comorbidity and quality of life. These recommendations are in contrast to most current clinical practice, which does not routinely include such assessment among ET patients. To our knowledge, there have been no pharmacotherapeutic trials to date of any agent for cognitive change associated with ET. We believe that studies for this indication are now called for. Future efforts in this direction will also need to take into account the pathobiology of cognitive changes in ET, which itself is an area that is ripe for future investigations.

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“…The Montreal Cognitive Assessment (MoCA) and the Addenbrooke's Cognitive Examination-Revised (ACE-R) are other brief global cognitive instruments that have been used to evaluate cognition in general population and in patients with PD 3,4 . Many studies reported that these scales can be useful and may be better than the MMSE to detect cognitive impairment in patients with PD 2,5,6,7,8,9,10,11,12,13,14,15 . In Brazil, the MoCA and ACE-R have been translated and adapted for clinical use, but their diagnostic validity in Brazilian clinical settings still remains uncertain 16,17,18,19 .…”

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confidence: 99%

Screening of cognitive impairment in patients with Parkinson's disease: diagnostic validity of the Brazilian versions of the Montreal Cognitive Assessment and the Addenbrooke's Cognitive Examination-Revised

Sobreira

Pena-Pereira

Éckeli

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective The aim of the present study is to examine the accuracy of the Brazilian versions of the Montreal Cognitive Assessment (MoCA) and the Addenbrooke's Cognitive Examination-Revised (ACE-R) to screen for mild cognitive impairment (PDMCI) and dementia (PDD) in patients with Parkinson's disease (PD).Method Both scales were administered to a final convenience sample of 79 patients with PD. Patients were evaluated by a neurologist, a psychiatrist and a neuropsychologist using UPDRS, Hoehn and Yahr and Schwab and England scales, global deterioration scale, a psychiatric structured interview, Mattis Dementia Rating Scale and other cognitive tests.Results There were 32 patients with PDMCI and 17 patients with PDD. The MoCA and the ACE-R were able to discriminate patients with PDD from the others.Conclusion Both scales showed to be useful to screen for dementia but not for mild cognitive impairment in patients with PD.

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Addenbrooke’s Cognitive Examination validation in Parkinson’s disease

Cited by 78 publications

References 38 publications

Thinking positively about chronic illness: An exploration of optimism, illness perceptions and well‐being in patients with Parkinson's disease

Thinking positively about chronic illness: An exploration of optimism, illness perceptions and well‐being in patients with Parkinson's disease

The cognitive side of essential tremor: what are the therapeutic implications?

Screening of cognitive impairment in patients with Parkinson's disease: diagnostic validity of the Brazilian versions of the Montreal Cognitive Assessment and the Addenbrooke's Cognitive Examination-Revised

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