Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress

Abstract

Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ.

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

“…Royal jelly (RJ) is a natural product produced by the hypopharyngeal and mandibular glands of worker bees. Previously, many studies reported that RJ exhibits different biological activities, including anti‐oxidative, immunomodulatory, antiviral, antibacterial, anti‐aging, and anti‐inflammatory activities (Caixeta et al, ; Pan et al, ). Currently, RJ is reported to have salutary effects on menopausal urogenital diseases, memory impairment, postmenopausal osteoporosis, and cardiovascular diseases (Hidaka et al, ; Minami et al, ; Seyyedi, Rafieankopaei, & Miraj, ).…”

Royal jelly attenuates cadmium-induced nephrotoxicity in male mice

“…Royal jelly consists of proteins (such as royalactin), monosaccharides, lipids, fatty acids (such as 10-hydroxy-2-decenoic acid and 10-HDA), free amino acids (eight essential amino acids valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, and lysine), minerals (such as Fe, Ca, K, Na, Mg, Zn, Cu, and Mn), and vitamins (A, B complex, E, and C) 7 . The biological benefits of royal jelly include antioxidant, anti-inflammatory, anti-aging, hypoglycemic, antitumor, and hypocholesterolemic activities 8–10 . Hence, this study aimed to explore the nephroprotective activity of royal jelly (RJ) against CdCl 2 -induced nephrotoxicity in male mice.…”

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

“…RJ could be considered as beneficial to inhibit liver toxicity induced by side effects of oxymetholone (OXM) and azathioprine through reducing the activities of serum hepatic enzymes and MDA formation [164,165]. RJ has a hepato-protective effect against oxidative impairment, decreasing lipoperoxidation and corticosterone, and enhancing total antioxidant capacity in liver tissue after stress induction in rats [166]. In addition, RJ treatment ameliorates the renal ischemia/reperfusion injury in rats via reducing blood urea nitrogen, kidney MDA, leukocyte infiltration, creatinine, adhesion molecule-1 expression, glomerular diameter, the level of TNF-α, and increased the tissue ferric reducing/antioxidant power [99].…”