Adaptogenic functions of extracellular autoregulators of microorganisms

Эль-Регистан, Г. И.; Mulyukin, A. L.; Nikolaev, Yu. A.; Suzina, N. E.; Гальченко, В. Ф.; Дуда, В. И.

doi:10.1134/s0026261706040035

Cited by 78 publications

(38 citation statements)

References 24 publications

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“…Also soils contain various organics, including pigments and microbial's growth autoregulators. It is shown that these substances play an important role in the stress tolerance of microorganisms [18,[78][79][80][81]. There is also information on the higher radioresistance of microorganisms in soils with high concentrations of humus, but these data are contradictory [82].…”

Section: Irradiation Of Pure Bacterial Cultures With Accelerated Elecmentioning

confidence: 99%

“…The protective role of intra-and interpopulation interactions can also be manifested through the production of some metabolites, as mentioned above. Moreover, microorganisms possess the quorum-sensing, which also contributes to resistance to adverse effects, in particular, to oxidative stress [18,83].…”

Section: Irradiation Of Pure Bacterial Cultures With Accelerated Elecmentioning

confidence: 99%

“…Microorganisms in natural heterophase mineral media (soils, sediments) are well protected against the stressful effects of physical and chemical factors. A lot of data there is published already on the increased resistance to stress of microorganisms in biofilms or microbial communities in situ in native habitat in comparison with pure microbial cultures [6,[14][15][16][17][18]. Therefore, in order to correctly assess the radioresistance of terrestrial microorganisms in the extraterrestrial regolith or other habitat, the closest possible reproduction of the relevant physicochemical factors is necessary, while preserving the natural environmental model, to which microbial communities are adapted.…”

Section: Introductionmentioning

confidence: 99%

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Survivability of Soil and Permafrost Microbial Communities after Irradiation with Accelerated Electrons under Simulated Martian and Open Space Conditions

et al. 2018

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Abstract:One of the prior current astrobiological tasks is revealing the limits of microbial resistance to extraterrestrial conditions. Much attention is paid to ionizing radiation, since it can prevent the preservation and spread of life outside the Earth. The aim of this research was to study the impact of accelerated electrons (~1 MeV) as component of space radiation on microbial communities in their natural habitat-the arid soil and ancient permafrost, and also on the pure bacterial cultures that were isolated from these ecotopes. The irradiation was carried out at low pressure (~0.01 Torr) and low temperature (−130 • C) to simulate the conditions of Mars or outer space. High doses of 10 kGy and 100 kGy were used to assess the effect of dose accumulation in inactive and hypometabolic cells, depending on environmental conditions under long-term irradiation estimated on a geological time scale. It was shown that irradiation with accelerated electrons in the applied doses did not sterilize native samples from Earth extreme habitats. The data obtained suggests that viable Earth-like microorganisms can be preserved in the anabiotic state for at least 1.3 and 20 million years in the regolith of modern Mars in the shallow subsurface layer and at a 5 m depth, respectively. In addition, the results of the study indicate the possibility of maintaining terrestrial like life in the ice of Europa at a 10 cm depth for at least~170 years or for at least 400 thousand years in open space within meteorites. It is established that bacteria in natural habitat has a much higher resistance to in situ irradiation with accelerated electrons when compared to their stability in pure isolated cultures. Thanks to the protective properties of the heterophase environment and the interaction between microbial populations even radiosensitive microorganisms as members of the native microbial communities are able to withstand very high doses of ionizing radiation.

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Section: Irradiation Of Pure Bacterial Cultures With Accelerated Elecmentioning

confidence: 99%

Section: Irradiation Of Pure Bacterial Cultures With Accelerated Elecmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Survivability of Soil and Permafrost Microbial Communities after Irradiation with Accelerated Electrons under Simulated Martian and Open Space Conditions

et al. 2018

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“…Phenols are frequent components in wastewaters of chemical recovery, organic synthesis, as well as hydrolytic, cellulose, and flax industries (Park et al 2012;Paisio et al 2010;Shourian et al 2009;Ren 2003). A range of phenolic substances are also synthesized and extracellularly excreted by many soil bacteria; the substances are used as molecular signals in microbial communication and as adaptogens (Stasiuk & Kozubek, 2010;El'-Registan et al 2006) and are Fig. 3 Bioluminescent intensity, I rel , at different HS concentrations, C HS .…”

Section: Detoxification Of Oxidizer Solutionsmentioning

confidence: 99%

Pollutant toxicity and detoxification by humic substances: mechanisms and quantitative assessment via luminescent biomonitoring

Kudryasheva

Tarasova

2014

Environ Sci Pollut Res

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The paper considers mechanisms of detoxification of pollutant solutions by water-soluble humic substances (HSs), natural detoxifying agents. The problems and perspectives of bioassay application for toxicity monitoring of complex solutions are discussed from ecological point of view. Bioluminescence assays based on marine bacteria and their enzymes are of special attention here; they were shown to be convenient tools to study the detoxifying effects on cellular and biochemical levels. The advantages of bioluminescent enzymatic assay for monitoring both integral and oxidative toxicities in complex solutions of model pollutants and HS were demonstrated. The efficiencies of detoxification of the solutions of organic oxidizers and salts of metals (including radioactive ones) by HS were analyzed. The dependencies of detoxification efficiency on time of exposure to HS and HS concentrations were demonstrated. Antioxidant properties of HS were considered in detail. The detoxifying effects of HS were shown to be complex and regarded as 'external' (binding and redox processes in solutions outside the organisms) and/or 'internal' organismal processes. The paper demonstrates that the HS can stimulate a protective response of bacterial cells as a result of (1) changes of rates of biochemical reactions and (2) stabilization of mucous layers outside the cell walls. Acceleration of auto-oxidation of NADH, endogenous reducer, by HS was suggested as a reason for toxicity increase in the presence of HS due to abatement of reduction ability of intracellular media.

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“…The HSLs are involved in quorum sensing, which is a mechanism of bacterial gene expression control in response to increasing cell density [2]. The RLs are synthesised by some pro-and eukaryotes [3] and operate as inductors of bacterial cell transition into the dormant stage [4]. On the other hand, these amphiphilic substances diffuse easily through epithelial barriers into human liquids and tissues where experimentally detected HSLs and RLs concentrations vary from nano-to micro-molar [5,6].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: a comparative study

Sviridova¹,

Deryabin²,

Cyganok³

et al. 2013

cejoi

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Adaptogenic functions of extracellular autoregulators of microorganisms

Cited by 78 publications

References 24 publications

Survivability of Soil and Permafrost Microbial Communities after Irradiation with Accelerated Electrons under Simulated Martian and Open Space Conditions

Survivability of Soil and Permafrost Microbial Communities after Irradiation with Accelerated Electrons under Simulated Martian and Open Space Conditions

Pollutant toxicity and detoxification by humic substances: mechanisms and quantitative assessment via luminescent biomonitoring

Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: a comparative study

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