Adaptogenic effects of curcumin on depression induced by moderate and unpredictable chronic stress in mice

Marques, Jéssica Gabriele da Silva; Antunes, Flavia Tasmin Techera; Brum, Lucimar Fillot da Silva; Pedron, Cláudia; Oliveira, Iasmine Berbigier de; Ferraz, Alexandre de Barros Falcão; Martins, Maria Isabel Morgan; Dallegrave, Eliane; Souza, Alessandra Hübner de

doi:10.1016/j.bbr.2020.113002

Cited by 30 publications

(19 citation statements)

References 40 publications

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“…In these studies, curcumin decreased serum corticosterone and increased BDNF and monoamine levels. Moreover, curcumin increased hippocampal neurogenesis and decreased brain monoamine oxidase activity, when compared to the stressed group (Bhutani et al, 2009; da Silva Marques et al, 2021; Xu et al, 2009, 2007, 2006). In rats submitted to UCS for 35 days, curcumin (40 mg/kg i.p.…”

Section: Resultsmentioning

confidence: 88%

Curcumin micronization by supercritical fluid:in vitroandin vivobiological relevance

Sachett

Gallas‐Lopes

Benvenutti

et al. 2021

Preprint

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Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. (Zingiberaceae), is shown to have antioxidant, anti-inflammatory, neuroprotective, anxiolytic, and antidepressant properties in both preclinical and clinical studies. However, its low bioavailability is a limitation for its potential adoption as a therapeutic agent. The process of micronization can overcome this barrier by reducing the particle size and increasing the dissolution rate, potentially improving the bioavailability of the compounds of interest. In this study, we compared the in vitro antioxidant effects of curcumin (CUR) and micronized curcumin (MC) and studied their effects on behavioral and neurochemical parameters in zebrafish submitted to unpredictable chronic stress (UCS). MC (1 g/L) presented higher antioxidant activity in vitro as compared to CUR, as measured by iron-reducing antioxidant power (FRAP), 1,1-diphenyl-2-2-picyryl-hydrazyl radical removal (DPPH), and deoxyribose tests. UCS increased total distance traveled in the social interaction test (SI), while decreased crossings, time, and entries to the top area in the novel tank test (NTT). No effects of UCS were observed in the open tank test (OTT). The behavioral effects induced by UCS were not blocked by any curcumin preparation. UCS also decreased non-protein thiols (NPSH) levels, while increased glutathione reductase (GR) activity and thiobarbituric acid reactive substances (TBARS) levels on zebrafish brain. MC presented superior antioxidant properties than CUR in vivo, blocking the stress-induced neurochemical effects. Although this study did not measure the concentration of curcumin on the zebrafish brain, our results suggest that micronization increases the bioavailability of curcumin, potentiating its antioxidant activity both in vitro and in vivo. Our study also demonstrates that counteracting the oxidative imbalance induced by UCS is not sufficient to block its behavioral effects.

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Section: Resultsmentioning

confidence: 88%

Curcumin micronization by supercritical fluid:in vitroandin vivobiological relevance

Sachett

Gallas‐Lopes

Benvenutti

et al. 2021

Preprint

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“…In this test, environmental manipulations (lighting and familiar or unfamiliar arena) can increase or decrease the number of times rats interact, thus allowing the assessment of anxiolytic (increased interaction) or anxiogenic (decreased interaction) effects (Gogas et al al., 2007). In this sense, the anxiolytic activity of curcumin has already been determined in several studies (Ceremuga et al, 2017;Lee, Lee, 2018;Marques et al, 2021).…”

Section: Discussionmentioning

confidence: 96%

“…Curcumin (In nity Pharma, São Paulo, Campinas, Brazil) was suspended in 0.5% carboxymethylcellulose (Pharmacia Amphora, Belo Horizonte, Minas Gerais, Brazil) and was then diluted in water immediately before use. Treatments consisted of administration of curcumin 50 mg/kg (SHR-C) (Marques et al, 2021), or vehicle (1 mL/kg) (SHR-V), or methylphenidate (1 mg/kg) (Kim et al, 2011). KY animals received vehicle only (1mL/kg).…”

Section: Experimental Designmentioning

confidence: 99%

Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation

Macedo

Antunes

Alvarenga

et al. 2021

Preprint

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Background: Curcumin has protective actions in neuropsychiatric disorders. Its mechanism of action is associated with the restoration of catecholaminergic balance, reduction of oxidative/nitrosative stress, protection against inflammation, and neuroprotection. Objective: In a first approach, the study presents an empty review of the potential effect of curcumin on cognitive performance in attention deficit hyperactivity disorder (ADHD).Methods: On a second moment, seeing the scarcity of studies and knowing that ADHD is related to hyperactive and anxious behavior, 20 spontaneously hypertensive Wistar rats (SHR) were divided into groups that received water (1 mg/kg/day), curcumin (50 mg/kg/day), or methylphenidate (1 mg/kg/day) for 42 days. Behavioral tests to assess activity (Open Field test), anxiety and impulsivity (Elevated Plus Maze, and Social Interaction), and memory (Y Maze and Object Recognition Test) were performed. Results: Animals treated with curcumin showed less anxious and hyperactive behavior. Related to the memory, the results can be related to hyperactivity. Conclusion: Thus, the data suggest that the treatments used here can beneficially modulate the anxious and hyperactive behavior of SHR.

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“…Curcumin (CUR), the major active component extracted from the Chinese medicine Curcuma longa, has been reported to possess neuroprotective effects [14]. CUR's potential antidepressant-like effects have been highlighted in many preclinical trials conducted on rats and mice models of depression [15][16][17][18]. Several clinical trials have also been conducted on the potential effectiveness of CUR in depression; however, they have yielded conflicting conclusions [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway

Sun

Guo

et al. 2021

Behavioural Neurology

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Background and Aim. Increasing evidence suggests that the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)/fibronectin type III domain-containing 5 (FNDC5)/brain-derived neurotrophic factor (BDNF) pathway might be critical for neuroprotection. Our present study is aimed at investigating the antidepressant-like effects of curcumin (CUR) in a chronic unpredictable mild stress- (CUMS-) induced depression rat model and explore whether the PGC-1α/FNDC5/BDNF pathway is the major driving force behind the therapeutic effects of CUR. Methods. All rats were randomly divided into four groups, namely, control, CUMS, CUMS + CUR , and CUMS + CUR + SR 18292 (PGC-1α inhibitor). Behavioral tests were conducted to assess the antidepressant-like effects of CUR. The expressions of PGC-1α, estrogen-related receptor alpha (ERRα), FNDC5, and BDNF were determined to investigate the regulatory effects of CUR on the PGC-1α/FNDC5/BDNF pathway. The PGC-1α inhibitor SR18292 was used to explore the role of PGC-1α in the induction of BDNF by CUR. Results. Daily gavage of 100 mg/kg CUR successfully attenuated the abnormal behaviors induced by CUMS and effectively prevented CUMS-induced reduction of PGC-1α, ERRα, FNDC5, and BDNF expressions. CUR also enhanced PGC-1α and ERRα translocation from cytoplasm to nucleus. Furthermore, we found that CUR supplementation effectively promoted neurocyte proliferation and suppressed neuronal apoptosis induced by CUMS. Of note, the PGC-1α inhibitor SR18292 remarkably reversed the beneficial effects of CUR on depressed rats, indicating an important role of PGC-1α in the antidepressant-like effects of CUR. Conclusion. Collectively, our data evaluating the neuroprotective action of CUR in the CUMS rats highlights the involvement of the PGC-1α/FNDC5/BDNF pathway in the antidepressant-like effects of CUR.

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Adaptogenic effects of curcumin on depression induced by moderate and unpredictable chronic stress in mice

Cited by 30 publications

References 40 publications

Curcumin micronization by supercritical fluid:in vitroandin vivobiological relevance

Curcumin micronization by supercritical fluid:in vitroandin vivobiological relevance

Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation

Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway

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