Adaptogenic Agents: A Review

Jawaid, Talha; Tewari, Nidhi; Verma, Lalita

doi:10.7439/ijbr.v2i5.104

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Adaptogens are plants known for restoring the body’s endurance and strength, helping adapt to stressful conditions, and increasing mental and physical performance [ 1 ]. At the molecular level, these plant substances have a regulatory effect on cellular metabolism, resulting in the ability to produce a swifter and simpler stress response, thereby maintaining homeostasis [ 2 , 3 ]. They are regarded as having complex effects on the human body, including effects on the nervous, immune, and endocrine systems.…”

Section: Introductionmentioning

confidence: 99%

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Wróbel-Biedrawa,

Podolak

2024

Molecules

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Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on the human body, increasing its ability to adapt, develop resilience, and survive in stress conditions. They are found in many traditional medicinal systems and play a key role in restoring the body’s strength and stamina. Research in recent years has attempted to elucidate the mechanisms behind their pharmacological effects, but it appears that these effects are difficult to define precisely and involve multiple molecular pathways. Neuroinflammation: In recent years, chronic inflammation has been recognized as one of the common features of many central nervous system disorders (dementia and other neurodegenerative diseases, depression, anxiety, ischemic stroke, and infections). Because of the specific nature of the brain, this process is called neuroinflammation, and its suppression can result in an improvement of patients’ condition and may promote their recovery. Adaptogens as anti-inflammatory agents: As has been discovered, adaptogens display anti-inflammatory effects, which suggests that their application may be broader than previously thought. They regulate gene expression of anti- and proinflammatory cytokines (prostaglandins, leukotriens) and can modulate signaling pathways (e.g., NF-κB). Aim: This mini-review aims to present the anti-neuroinflammatory potential of the most important plants classified as adaptogens: Schisandra chinensis, Eleutherococcus senticosus, Rhodiola rosea and Withania somnifera.

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Section: Introductionmentioning

confidence: 99%

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Wróbel-Biedrawa,

Podolak

2024

Molecules

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“…Родиола розовая (Rhodiola rosea L.), фармакопейным сырьем которой являются корневища и корни, применяется в официальной медицине для получения лекарственных препаратов с адаптогенной активностью. [1][2][3][4][5][6]. Виды рода Rhodiola sp.…”

Section: Introductionunclassified

Standardization Problems of Medicinal Preparations From Rhodiola Rosea L.

Куркин¹,

Рязанова²

2021

Farm. farmakol. (Pâtigorsk)

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Rhodiola rosea L. rhizomes and roots are pharmacopoeial raw materials, which are used in official medicine for obtaining medicines with adaptogenic activity. One of the most common problems in the production of medicines from Rhodiola rosea L. rhizomes and roots is the use of poor quality medicinal plant materials, which leads to the absence of biologically significant compounds in the preparations. One of the possible reasons is the shortcomings in the existing approaches to the standardization of Rhodiola rosea L. raw materials and preparations.The aim of the study is the improvement of approaches to the standardization of medicinal preparations from Rhodiola rosea L. rhizomes and roots.Materials and methods. Experimental and industrial samples of liquid extract from Rhodiola rosea L. roots, as well as reference samples of rosavin and salidroside, were used as materials of the research. The HPLC analysis was carried out using a Milichrom-6 chromatograph (NPAO Nauchpribor) under the following conditions of reversed-phase chromatography in an isocratic mode: a steel column KAKH-6-80-4 (2 mm x 80 mm; Separon-C18 7 μm), a mobile phase – acetonitrile: 1% solution of acetic acid in water in the ratio of 14:86, the elution rate was 100 μL/min, the eluent volume was 2000 μL. The constituents were detected at the wavelength of 252 nm (rosavin) and 278 nm (salidroside).Results. An assay of rosavin and salidroside in the liquid extract of Rhodiola rosea L. was developed using the HPLC method. It was determined that the content of rosavin in the samples of the liquid extracts obtained from Rhodiola rosea L. rhizomes and roots of the pharmacopoeial quality, varied from 0.21%±0.03% to 0.32%±0.04%, salidroside – from 1.13% ±0.05% to 2.71%±0.12%, respectively. The results of statistical processing indicate that the relative error of the average result for the determination of rosavin and salidroside in the preparations of Rhodiola rosea L. with a confidence level of 95% does not exceed ±6.0%.Conclusion. Thus, methodological approaches to the analysis of medicinal preparations from Rhodiola rosea L. rhizomes and roots have been substantiated. These methodological approaches consist of the quantitative determination of the dominant and diagnostically significant biologically active compounds – rosavin and salidroside.

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“…Adaptogens are the plant-derived biologically active substances that appear to induce a state of non-specific increase of resistance of the organism to diverse assaults that threaten internal homeostasis and improve physical endurance (Jawaid et al, 2011). Adaptogens modulate body response to stress (physical, environmental or emotional) and helps to regulate the interconnected endocrine, immune and nervous systems.…”

Section: Introductionmentioning

confidence: 99%

Can Emblica officinalis and Tinospora cordifolia supplementation possess immunomodulatory and adaptogenic properties in murrah buffalo calves?

Patel

Singh

Mishra

et al. 2017

IJAR

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The present investigation was conducted to evaluate the combined effect of Emblica officinalis and Tinospora cordifolia supplementation on growth performance, hormonal and immune status in murrah buffalo calves. 14 day age unsupplementated 6 calves were taken as control, whereas 6 calves of treatment group were supplemented with combination of Emblica officinalis and Tinospora cordifolia (2:1) @ 450 mg/ kg body weight once a day orally for 28 days. The results indicated that, significant (p<0.05) higher body weight in treatment group as compare to control group. Serum cortisol concentration was significantly (p<0.05) lower in treatment group. Higher level of T 4 hormone, immunoglobulins and adaptability coefficient was observed in Emblica officinalis and Tinospora cordifolia treated group. It indicated that combination of Emblica officinalis and Tinospora cordifolia possess immunogenic effect and by inducing a state of non-specific increase in resistance to diverse climatic conditions they help to prevent calf mortality.

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Adaptogenic Agents: A Review

Cited by 5 publications

References 36 publications

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Standardization Problems of Medicinal Preparations From Rhodiola Rosea L.

Can Emblica officinalis and Tinospora cordifolia supplementation possess immunomodulatory and adaptogenic properties in murrah buffalo calves?

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