Adaptive Optics Imaging of Healthy and Abnormal Regions of Retinal Nerve Fiber Bundles of Patients With Glaucoma

Abstract

The AO-SLO images revealed details of glaucomatous damage that are difficult, if not impossible, to see with current OCT technology. Adaptive optics SLO may prove useful in following progression in clinical trials, or in disease management, if AO-SLO becomes widely available and easy to use.

Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps

“…6,7 These eyes had deep arcuate defects in the macula (five points À15 db on the total deviation plot of the 10-2 visual field [VF]), marked RNFL thinning on cpRNFL thickness plots from SDOCT circumpapillary scans, and abnormal and/or missing RNFL bundles on AO-SLO images. The AO-SLO images were obtained with a custom-built instrument 17 and then montaged to obtain an image such as the one shown in Figure 1A.…”

“…The AO-SLO images were obtained with a custom-built instrument 17 and then montaged to obtain an image such as the one shown in Figure 1A. 6,7 The patients' identification numbers used here correspond to those in Reference 7.…”

Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans

“…With AO-SLO, the RNF bundles can be imaged [5][6][7][8][9] and changes due to glaucoma visualized. 6,7,9 These changes include those difficult or impossible to see with currently available commercial fdOCT. 9 In the present study, we compared AO-SLO images of RNFL bundles near the disc to the circumpapillary fdOCT scans of patients with arcuate-like defects in the central 6108 of vision.…”

Enhancing Structure–Function Correlations in Glaucoma with Customized Spatial Mapping

“…One such measure is the signal strength of the OCT, which has been shown to decrease in glaucomatous subjects compared to with healthy subjects. 51 Analyzing and interpreting signal strength is nontrivial because various other factors such as media opacity, angle of incidence of the light beam, and the scattering properties of the tissue also affect the measured signal strength. Previous reports suggest that the attenuation coefficient of the RNFL is less affected by these factors.…”