Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans

Hood, Donald C.; Chen, Monica F.; Lee, Dongwon; Epstein, Benjamin; Alhadeff, Paula; Rosen, Richard B.; Ritch, Robert; Dubra, Alfredo; Chui, Toco Y. P.

doi:10.1167/tvst.4.2.12

Cited by 24 publications

(27 citation statements)

References 15 publications

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“…6,7 These eyes had deep arcuate defects in the macula (five points À15 db on the total deviation plot of the 10-2 visual field [VF]), marked RNFL thinning on cpRNFL thickness plots from SDOCT circumpapillary scans, and abnormal and/or missing RNFL bundles on AO-SLO images. The AO-SLO images were obtained with a custom-built instrument 17 and then montaged to obtain an image such as the one shown in Figure 1A.…”

Section: Methods Patientsmentioning

confidence: 99%

“…The AO-SLO images were obtained with a custom-built instrument 17 and then montaged to obtain an image such as the one shown in Figure 1A. 6,7 The patients' identification numbers used here correspond to those in Reference 7.…”

Section: Methods Patientsmentioning

confidence: 99%

“…Adaptive optics applied to either OCT (AO-OCT) or to scanning laser ophthalmoscopy (AO-SLO) provide better lateral resolution and enable the visualization of individual axon bundles. [1][2][3][4][5][6][7] These bundles are less reflective and/or missing from the RNFL in eyes with glaucoma. [4][5][6][7] Recently, Hood et al 7 showed that locations with equally thinned cpRNFL, as measured with OCT, had different patterns of RNFL bundle loss when imaged with AO-SLO.…”

mentioning

confidence: 99%

“…To compare the details of local glaucomatous damage seen on OCT en face images to those seen on OCT RNFL thickness maps, we analyzed wide-field, swept-source (ss)OCT scans of patients for whom peripapillary AO-SLO images, 7 as in Figure 1A, were available. In particular, following Fortune et al (Fortune B, et al IOVS 2014;55:ARVO E-Abstract 2644), we derived projection images by averaging the reflectance intensity of a fixed axial portion of each A-scan, thus creating an image of a ''slab'' with fixed thickness below the vitreous/ inner limiting membrane (V/ILM).…”

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confidence: 99%

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Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps

Hood

Fortune

Mavrommatis

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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119

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PURPOSE. High-resolution images of glaucomatous damage to the retinal nerve fiber layer (RNFL) were obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO) and used as a basis for comparisons between en face slab images and thickness maps derived from optical coherence tomography (OCT) scans. METHODS.Wide-field (9 3 12 mm) cube scans were obtained with swept-source OCT (DRI-OCT) from six eyes of six patients. All eyes had a deep defect near fixation as seen on a 10-2 visual field test. Optical coherence tomography en face images, based on the average reflectance intensity, were generated (ATL 3D-Suite) from 52-lm slabs just below the vitreal border of the inner limiting membrane. The RNFL thickness maps were generated from the same OCT data. Both were compared with the AO-SLO peripapillary images that were previously obtained. RESULTS.On AO-SLO images, three eyes showed small regions of preserved and/or missing RNFL bundles within the affected region. Details in these regions were seen on the OCT en face images but not on the RNFL thickness maps. In addition, in the healthier hemi-retinas of two eyes, there were darker, arcuate-shaped regions on en face images that corresponded to abnormalities seen on AO-SLO. These were not seen on RNFL thickness maps.CONCLUSIONS. Details of local glaucomatous damage, missing or easily overlooked on traditional OCT RNFL thickness analysis used in clinical OCT reports, were seen on OCT en face images based on the average reflectance intensity. While more work is needed, it is likely that en face slab imaging has a role in the clinical management of glaucoma.

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Section: Methods Patientsmentioning

confidence: 99%

Section: Methods Patientsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps

Hood

Fortune

Mavrommatis

et al. 2015

Invest. Ophthalmol. Vis. Sci.

Self Cite

119

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“…게다가 단층화를 이용하여 나이 관련 황반 변성 등 드 루젠과 관련하여 시세포층의 동반된 변화를 가져오는 다양한 질환을 연구하는 데 도움을 받을 수 있다 [3,4]. 또한 신경섬유 층의 관찰을 통하여 신경섬유의 녹내장성 변화를 평가하는 좋 은 도구로 평가되기도 하였다 [17,18]. AO-SLO는 망막 시세포층 과 신경섬유층 사이의 혈관을 관찰하는 데도 유용하게 사용될 수 있는데, 이때 혈액과 혈관에 의해 긴 파장의 빛은 흡수되며, 중심 와 주변 모세혈관의 적혈구와 백혈구의 움직임에 의한 이 미지만 시간에 따른 다양성을 가지므로, 조영 증강 없이 중심 와 주변 모세혈관망을 포함한 망막 중심 와 무혈관 부위를 면 밀하게 관찰할 수 있다 [19][20][21].…”

Section: Principles Of Ao-slounclassified

Principles of Adaptive Optics and Clinical Applications

Park

2017

J Retin

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The human retina is a uniquely accessible tissue. Tools like scanning laser ophthalmoscopy and spectral domain optical coherence tomography provide clinicians with remarkably clear pictures of the living retina. While the anterior optics of the eye permit such non-invasive visualization of the retina and associated pathology, these same optics induce significant aberrations that in most cases obviate cellular-resolution imaging. Adaptive optics (AO) imaging systems use active optical elements to compensate for aberrations in the optical path between the object and the camera. Applied to the human eye, AO allows direct visualization of individual rod and cone photoreceptor cells, Retina pigment epithelial cells and white blood cells. AO imaging has changed the way vision scientists and ophthalmologists see the retina, helping to clarify our understanding of retinal structure, function and the etiology of various retinal pathologies. Here we review some of the advances made possible with AO imaging of the human retina and discuss applications and future prospects for clinical imaging.

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Recent Developments in Glaucoma

Kerr

Barton

2019

Current Concepts in Ophthalmology

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Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans

Cited by 24 publications

References 15 publications

Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps

Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps

Principles of Adaptive Optics and Clinical Applications

Recent Developments in Glaucoma

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