Adapting social conditioned place preference for use in young children

Baron, David; Holland, Cristin M.; Carlson, Kaitlin S.; Wolfrum, Emily; Thompson, Barbara L.

doi:10.1016/j.nlm.2020.107235

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Established paradigms in rodents that induce social isolation or overcrowding have the utility to be adapted in human samples (Mueller and de Wit, 2011). For example, the social place preference paradigm was originally developed using rodent models to assess social motivation but has been adapted to study social aversion among neurodivergent young children (Baron et al, 2020) and has been applied to human adults in a virtual reality setting (Childs et al, 2017). However, without rigorous and controlled animal experimental models using standardized procedures the validity of these paradigms becomes questionable and their application to humans loses utility (Matthews and Tye, 2019).…”

Section: Methodological Challenges and Approachesmentioning

confidence: 99%

Individual differences in social homeostasis

Bales

Hang²,

Paulus³

et al. 2023

Front. Behav. Neurosci.

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The concept of “social homeostasis”, introduced by Matthews and Tye in 2019, has provided a framework with which to consider our changing individual needs for social interaction, and the neurobiology underlying this system. This model was conceived as including detector systems, a control center with a setpoint, and effectors which allow us to seek out or avoid additional social contact. In this article, we review and theorize about the many different factors that might contribute to the setpoint of a person or animal, including individual, social, cultural, and other environmental factors. We conclude with a consideration of the empirical challenges of this exciting new model.

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Section: Methodological Challenges and Approachesmentioning

confidence: 99%

Individual differences in social homeostasis

Bales

Hang²,

Paulus³

et al. 2023

Front. Behav. Neurosci.

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“…The motivational effects of drugs (Shipman et al, 2006;De Wit, 2009, 2016;Palmisano et al, 2018), food (Astur et al, 2014), money (Astur et al, 2016), music (Molet et al, 2013), and toys (Hiller et al, 2015) have been successfully investigated in humans by using CPP paradigms (review, Linhardt et al, 2022). A recent pioneer study retranslated the SCPP to humans (Baron et al, 2020). Baron and others used a friendly adult person willing to play with a child as an appetitive stimulus and showed successful CPP in two groups of young children, i.e., typically developing children and children with autism spectrum disorder.…”

Section: Introductionmentioning

confidence: 99%

A virtual reality social conditioned place preference paradigm for humans: Does trait social anxiety affect approach and avoidance of virtual agents?

Kiser

Gromer²,

Pauli³

et al. 2022

Front. Virtual Real.

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Approach and avoidance of positive and negative social cues are fundamental to prevent isolation and ensure survival. High trait social anxiety is characterized by an avoidance of social situations and extensive avoidance is a risk factor for the development of social anxiety disorder (SAD). Therefore, experimental methods to assess social avoidance behavior in humans are essential. The social conditioned place preference (SCPP) paradigm is a well-established experimental paradigm in animal research that is used to objectively investigate social approach–avoidance mechanisms. We retranslated this paradigm for human research using virtual reality. To this end, 58 healthy adults were exposed to either a happy- or angry-looking virtual agent in a specific room, and the effects of this encounter on dwell time as well as evaluation of this room in a later test without an agent were examined. We did not observe a general SCPP effect on dwell time or ratings but discovered a moderation by trait social anxiety, in which participants with higher trait social anxiety spent less time in the room in which the angry agent was present before, suggesting that higher levels of trait social anxiety foster conditioned social avoidance. However, further studies are needed to verify this observation and substantiate an association with social anxiety disorder. We discussed the strengths, limitations, and technical implications of our paradigm for future investigations to more comprehensively understand the mechanisms involved in social anxiety and facilitate the development of new personalized treatment approaches by using virtual reality.

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