Adaptation reactions of hemodynamic systems on artificially modulated stress in healthy individuals

Abstract

Aim. To study the influence of artificially created stress on hemodynamic parameters of peripheral microcirculation and variability of the heart rhythm in somatically healthy young individuals.
 Materials and Methods. In the study 30 individuals were involved (of them 16 men) with the mean age 18.21.1 years. An artificial stress was created using Stroop method. Assessment of characteristics of hemodynamics of microcirculation (HM) was performed by the method of dynamic scattering of light from erythrocytes. The signal was integrated in the form of three hemodynamic indexes: HI (Hemodynamic Indexes). Low frequency index (HI1) was determined by a slow interlayer interaction, high frequency area (HI3) characterized fast shearing of layers. HI2 took intermediate position (precapillary and capillary blood flow). Variability of cardiointervals isolated from pulse component, was assessed by method of variation pulsometry (Heart Rate Variability, HRV).
 Results. In the course of study, increase in the heart rate (HR) in the stage of testing was observed that confirms a high extent of stress load. In hemodynamics, redistribution of blood flow was noted toward slow shear velocities (near-wall blood flow). After cessation of stress load, hemodynamic parameters declined and returned to previous values. Parameters characterizing variability of rhythm LF (sympathetic component), HF (vagal activity), CVI (non-linear parasympathetic index) showed a tendency to growth; here, LF/HF ratio did not change.
 Conclusion. In result of the carried out study it was possible to formulate a multifactor picture of variation of parameters of microcirculation and of autonomic regulation of cardiac rhythm specific of reactions of adaptation to induced stress. The quantitative criteria of the obtained shears may be integrated into stress indexes to be used in clinical practice. A portable mDLS sensor may be supplemented with specific assessment criteria and used for monitoring of adaptive reactions induced by stressful situations, and for taking early diagnostic and prognostic decisions in the clinical practice, and for self-control of a patient.

Status of the mucosa of the upper gastrointestinal tract in patients with acute viral hepatitis B

“…Ряд исследователей склонны считать причиной формирования таких изменений -нарушение кровообращения и ишемизацию подслизистого слоя [16,17]. Причинами которой, может служить включение ренин-ангиотензин-альдостероновой системы на ранних стадиях острого вирусного гепатита В или непосредственное изменение микроциркуляции с усилением явлений адгезии, закономерно возникающих при стрессовых состояниях [18,19].…”