Adaptation in synergistic muscles to soleus and plantaris muscle removal in the rat hindlimb

Kandarian, Susan C.; Young, John C.; Gómez, Eulogio Valentín

doi:10.1016/0024-3205(92)90314-f

Cited by 8 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twelve weeks postablation, wet weight was similar among TA muscles from the ablated (446 -35 mg) and contralateral control (440 -27 mg) legs ( p = 0.701), indicating that synergist ablation did not provide a significant overload to uninjured muscle similar to that reported for the posterior compartment. 31 Importantly, because synergist ablation resulted in an & 30% reduction of normalized peak tetanic torque, a complete recovery of TA muscle function following VML injury is reflected by the return of & 70% of preinjury tetanic torque on that same animal using this metric.…”

Section: Synergist Muscle Ablationmentioning

confidence: 99%

Implantation ofIn VitroTissue Engineered Muscle Repair Constructs and Bladder Acellular Matrices Partially RestoreIn VivoSkeletal Muscle Function in a Rat Model of Volumetric Muscle Loss Injury

Corona

Ward²,

Baker³

et al. 2013

Tissue Engineering Part A

110

163

View full text Add to dashboard Cite

The frank loss of a large volume of skeletal muscle (i.e., volumetric muscle loss [VML]) can lead to functional debilitation and presents a significant problem to civilian and military medicine. Current clinical treatment for VML involves the use of free muscle flaps and physical rehabilitation; however, neither are effective in promoting regeneration of skeletal muscle to replace the tissue that was lost. Toward this end, skeletal muscle tissue engineering therapies have recently shown great promise in offering an unprecedented treatment option for VML. In the current study, we further extend our recent progress (Machingal et al., 2011, Tissue Eng; Corona et al., 2012, Tissue Eng) in the development of tissue engineered muscle repair (TEMR) constructs (i.e., muscle-derived cells [MDCs] seeded on a bladder acellular matrix (BAM) preconditioned with uniaxial mechanical strain) for the treatment of VML. TEMR constructs were implanted into a VML defect in a tibialis anterior (TA) muscle of Lewis rats and observed up to 12 weeks postinjury. The salient findings of the study were (1) TEMR constructs exhibited a highly variable capacity to restore in vivo function of injured TA muscles, wherein TEMR-positive responders (n=6) promoted an ≈61% improvement, but negative responders (n=7) resulted in no improvement compared to nonrepaired controls, (2) TEMR-positive and -negative responders exhibited differential immune responses that may underlie these variant responses, (3) BAM scaffolds (n=7) without cells promoted an ≈26% functional improvement compared to uninjured muscles, (4) TEMR-positive responders promoted muscle fiber regeneration within the initial defect area, while BAM scaffolds did so only sparingly. These findings indicate that TEMR constructs can improve the in vivo functional capacity of the injured musculature at least, in part, by promoting generation of functional skeletal muscle fibers. In short, the degree of functional recovery observed following TEMR implantation (BAM+MDCs) was 2.3×-fold greater than that observed following implantation of BAM alone. As such, this finding further underscores the potential benefits of including a cellular component in the tissue engineering strategy for VML injury.

show abstract

Section: Synergist Muscle Ablationmentioning

confidence: 99%

Implantation ofIn VitroTissue Engineered Muscle Repair Constructs and Bladder Acellular Matrices Partially RestoreIn VivoSkeletal Muscle Function in a Rat Model of Volumetric Muscle Loss Injury

Corona

Ward²,

Baker³

et al. 2013

Tissue Engineering Part A

110

163

View full text Add to dashboard Cite

show abstract

“…On the basis of gel electrophoresis analyses, FO of the rat plantaris has been shown to result in increases in the percent composition of type I, IIa, and IIx and a decrease in type IIb myosin heavy chains (MHCs) (8,10,19,23,37,38). The effects of exercise on the degree of conversion from fast to slow fibers in FO muscles, however, are equivocal.…”

mentioning

confidence: 99%

“…This contention is supported by the observation that in cats, a relatively sedentary animal, FO of the plantaris has little effect on the mass of the muscle unless the cat is exercised. In addition, the largest amount of hypertrophy was found when the cats were subjected to high-intensity exercise, i.e., sprinting and jumping (26,29).On the basis of gel electrophoresis analyses, FO of the rat plantaris has been shown to result in increases in the percent composition of type I, IIa, and IIx and a decrease in type IIb myosin heavy chains (MHCs) (8,10,19,23,37,38). The effects of exercise on the degree of conversion from fast to slow fibers in FO muscles, however, are equivocal.…”

mentioning

confidence: 99%

Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers

Roy

Talmadge

Fox

et al. 1997

Journal of Applied Physiology

View full text Add to dashboard Cite

Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers. J. Appl. Physiol. 83(1): 280-290, 1997.-The effects of 1 and 10 wk of functional overload (FO) of the rat plantaris with (FO Tr ) and without daily endurance treadmill training on its myosin heavy chain (MHC) composition were studied. After 1 and 10 wk of FO, plantaris mass was 22 and 56% greater in FO and 37 and 94% greater, respectively, in FO Tr rats compared with agematched controls. At 1 wk, pure type I and pure type IIa MHC fibers were hypertrophied in FO (39 and 44%) and FO Tr (70 and 87%) rats. By 10 wk all fiber types comprising .5% of the fibers sampled showed a hypertrophic response in both FO groups. One week of FO increased the percentage of hybrid (containing both type I and type IIa MHC) fibers and of fibers containing embryonic MHC. By 10 wk, the percentage of pure type I MHC fibers was ,40% in both FO groups compared with 15% in controls, and the percentage of fibers containing embryonic MHC was similar to that in controls. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses showed an increase in type I MHC and a decrease in type IIb MHC in both FO groups at 10 wk, whereas little change was observed at 1 wk. These data are consistent with hypertrophy and transformation from faster to slower MHC isoforms in chronically overloaded muscles. The additional overload imposed by daily endurance treadmill training employed in this study (1.6 km/day; 10% incline) results in a larger hypertrophic response but appears to have a minimal effect on the MHC adaptations.immunohistochemistry; gel electrophoresis; hypertrophy; fiber type conversion; fiber size FUNCTIONAL OVERLOAD (FO) of the rat plantaris by removal of its major synergists results in hypertrophy and a shift in the contractile, biochemical, and metabolic properties toward those observed in a ''slower'' muscle (26). The extent of these adaptations may be related, in part, to the activity level of the rats after surgery. For example, it appears that the amount of hypertrophy is greater in rats that are exercised on a treadmill than in rats not exercised after FO (13,25), although this is somewhat controversial (3). Thus one of the mechanisms regulating muscle hypertrophy may be the amount and/or type of activity that the overloaded muscle experiences after ablation of its synergists. This contention is supported by the observation that in cats, a relatively sedentary animal, FO of the plantaris has little effect on the mass of the muscle unless the cat is exercised. In addition, the largest amount of hypertrophy was found when the cats were subjected to high-intensity exercise, i.e., sprinting and jumping (26,29).On the basis of gel electrophoresis analyses, FO of the rat plantaris has been shown to result in increases in the percent composition of type I, IIa, and IIx and a decrease in type IIb myosin heavy chains (MHCs) (8,10,19,23,37,38). The effects of exercise on the degree of conversion from fast to slow fibers in FO muscles, however, are e...

show abstract

“…6 " 10 The initial deficits at the donor site may not be permanent, since the synergistic muscles that remain intact will hypertrophy in response to the relocation of the donor muscle. 19 " 24 Following removal of the MGN muscle, the remaining threemuscle plantar flexor group displayed a 27 percent increase in force production, compared with initial values. Although the synergistic muscles were unable to compensate for the entire deficit at the donor site, the significant restoration of muscle-group function is promising.…”

Section: Discussionmentioning

confidence: 96%

Functional Evaluation at the Medial Gastrocnemius Donor Site in Rats

Miller¹,

Opiteck²,

White³

1996

J reconstr Microsurg

View full text Add to dashboard Cite

The transfer of a skeletal muscle from a donor to a recipient site creates an initial deficit in the structure and function of the muscle group from which it originates. Removal of the donor muscle induces hypertrophy of the remaining synergistic muscles, which compensate for part of the deficit at the donor site. The medial gastrocnemius (MGN) muscle is a frequently utilized donor muscle. Compared with the mass and force production of the control four-muscle plantar flexor group in rats, removal of the MGN muscle creates an initial deficit of approximately 36 percent. At 60, 90, and 120 days after removal of the MGN muscle, the degree of compensation of the remaining three-muscle plantar flexor group (lateral gastrocnemius, soleus, and plantaris muscles) was evaluated. The mass of the three-muscle group increased 13 percent over the time course studied, but was still 28 percent less than the mass of the control four-muscle group. Similarly, the maximum force of the three-muscle group increased 27 percent, but was 21 percent lower than the control four-muscle group. The authors propose a model that illustrates the function restored at a donor site in terms of the percentage of the total muscle group comprised by the donor muscle and the ability of the remaining muscle group to compensate for its removal.

show abstract

Adaptation in synergistic muscles to soleus and plantaris muscle removal in the rat hindlimb

Cited by 8 publications

References 23 publications

Implantation ofIn VitroTissue Engineered Muscle Repair Constructs and Bladder Acellular Matrices Partially RestoreIn VivoSkeletal Muscle Function in a Rat Model of Volumetric Muscle Loss Injury

Implantation ofIn VitroTissue Engineered Muscle Repair Constructs and Bladder Acellular Matrices Partially RestoreIn VivoSkeletal Muscle Function in a Rat Model of Volumetric Muscle Loss Injury

Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers

Functional Evaluation at the Medial Gastrocnemius Donor Site in Rats

Contact Info

Product

Resources

About