Adapalene gel 0.3% for the treatment of acne vulgaris: A multicenter, randomized, double-blind, controlled, phase III trial

Thiboutot, Diane; Pariser, David M.; Egan, Nancy; Flores, Javier; Herndon, James H.; Kanof, Norman B.; Kempers, Steven; Maddin, Stuart; Poulin, Yves; Wilson, David C.; Hwa, Joyce; Liu, Yin; Graeber, Michael

doi:10.1016/j.jaad.2004.10.879

Cited by 52 publications

(36 citation statements)

References 23 publications

(18 reference statements)

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“…However, its treatment-related adverse events are major concerned issues that can affect patients' adherence (21). Although, adapalene gel is a third generation topical retinoid which may cause less local irritation than other topical retinoids, previous studies showed that approximately 10-40% of acne patients treated with 0.1% adapalene gel had skin irritations (3,22,23). The most treatment-related adverse events were scaling, dryness and erythema (23).…”

Section: Discussionmentioning

confidence: 99%

A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel

Chularojanamontri

Tuchinda

Kulthanan

et al. 2015

Journal of Dermatological Treatment

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Section: Discussionmentioning

confidence: 99%

A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel

Chularojanamontri

Tuchinda

Kulthanan

et al. 2015

Journal of Dermatological Treatment

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“…16,17 In addition, a nonmedical photographer rated the quality of the images using the Q-index. 18 The Q-index was developed to assess professional photographs using elements that are broadly accepted in judging photographic quality: framing, lighting, and exposure.…”

Section: Methodsmentioning

confidence: 99%

Remote Assessment of Acne: The Use of Acne Grading Tools to Evaluate Digital Skin Images

Bergman

Tsai

Seo

et al. 2009

Telemedicine and e-Health

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Digital imaging of dermatology patients is a novel approach to remote data collection. A number of assessment tools have been developed to grade acne severity and to track clinical progress over time. Although these tools have been validated when used in a face-to-face setting, their efficacy and reliability when used to assess digital images have not been examined. The main purpose of this study was to determine whether specific assessment tools designed to grade acne during face-to-face visits can be applied to the evaluation of digital images. The secondary purpose was to ascertain whether images obtained by subjects are of adequate quality to allow such assessments to be made. Three hundred (300) digital images of patients with mild to moderate facial inflammatory acne from an ongoing randomized-controlled study were included in this analysis. These images were obtained from 20 patients and consisted of sets of 3 images taken over time. Of these images, 120 images were captured by subjects themselves and 180 were taken by study staff. Subjects were asked to retake their photographs if the initial images were deemed of poor quality by study staff. Images were evaluated by two dermatologists-in-training using validated acne assessment measures: Total Inflammatory Lesion Count, Leeds technique, and the Investigator's Global Assessment. Reliability of raters was evaluated using correlation coefficients and kappa statistics. Of the different acne assessment measures tested, the inter-rater reliability was highest for the total inflammatory lesion count (r = 0.871), but low for the Leeds technique (kappa = 0.381) and global assessment (kappa = 0.3119). Raters were able to evaluate over 89% of all images using each type of acne assessment measure despite the fact that images obtained by study staff were of higher quality than those obtained by patients (p < 0.001). Several existing clinical assessment measures can be used to evaluate digital images obtained from subjects with inflammatory acne lesions. The level of inter-rater agreement is highly variable across assessment measures, and we found the Total Inflammatory Lesion Count to be the most reliable. This measure could be used to allow a dermatologist to remotely track a patient's progress over time.

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“…This degree of acne is considered mild, or even a treatment success, in many randomized controlled trials of acne therapies. 26,27 Statistical analyses A sample size estimate was performed before data collection. Our primary question was to determine the prevalence of BDD in those with acne.…”

Section: Methodsmentioning

confidence: 99%

Body dysmorphic disorder symptoms among patients with acne vulgaris

Bowe¹,

Leyden²,

Crerand

et al. 2007

Journal of the American Academy of Dermatology

125

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Adapalene gel 0.3% for the treatment of acne vulgaris: A multicenter, randomized, double-blind, controlled, phase III trial

Cited by 52 publications

References 23 publications

A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel

A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel

Remote Assessment of Acne: The Use of Acne Grading Tools to Evaluate Digital Skin Images

Body dysmorphic disorder symptoms among patients with acne vulgaris

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