A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel

Chularojanamontri, Leena; Tuchinda, Papapit; Kulthanan, Kanokvalai; Varothai, Supenya; Winayanuwattikun, Waranaree

doi:10.3109/09546634.2015.1079298

Cited by 24 publications

(31 citation statements)

References 31 publications

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“…Skin care formulation containing licochalcone A, L-carnitine, and 1,2-decanediol can reduce pustule lesions, popular lesions, total lesions, and sebum levels [92]. A combination of 0.1% adapalene gel and moisturizer containing licochalcone A, L-carnitine, and 1,2-decanediol also showed synergistic effect in reducing inflammatory lesions without interfering the efficacy of each active ingredient [93]. Another combination between 0.1% adapalene gel and moisturizer containing licochalcone A, glycolic acid, salicylic acid, and gluconolactone even showed better results than monotherapy using only adapalene [94].…”

Section: Acne Vulgarismentioning

confidence: 98%

Chalcones in Dermatology

Jumina¹,

Harizal²,

Kurniawan³

2021

Beauty - Cosmetic Science, Cultural Issues and Creative Developments

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The human skin is pivotal for protecting the body from various stresses and diseases, regulating several physiological aspects, and sensing any signal changes around the environment. To work and function optimally, the skin should be protected and cared regularly by using some treatments. Chalcone, as a privileged structure, exhibits wide and unique bioactivities related to several skin disorders such as in preventing and treating pigmentation disorders (melasma and vitiligo), cutaneous leishmaniasis, rashes (acne vulgaris, seborrheic dermatitis and dandruff, psoriasis and atopic dermatitis), and rosacea. In this chapter, the role of chalcone derivatives in treating several skin disorders as mentioned above is discussed to provide a brief and comprehensive perspective regarding the role of chalcone in dermatology including in vitro, preclinical, and clinical assays.

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Section: Acne Vulgarismentioning

confidence: 98%

Chalcones in Dermatology

Jumina¹,

Harizal²,

Kurniawan³

2021

Beauty - Cosmetic Science, Cultural Issues and Creative Developments

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“…59 However, addition of a non-comedogenic moisturizer (licochalcone A, L-carnitine and 1.2-decanediol) significantly improved tolerability by reducing skin irritation symptoms and TEWL. 59 The efficacy of adapalene was improved by use of moisturizer, because there were fewer inflammatory flares and a more rapid onset of action in reducing acne lesions. 59 Kim et al 60 compared the efficacy and tolerability of A-BPO 0.1% versus adapalene gel 0.1% in treatment of Asian patients (n = 23) with acne in a 12-week, split-face, observer-blinded study in Korea.…”

Section: Retinoids In Asian Skinmentioning

confidence: 99%

Section: Using Topical Retinoids In Skin Of Colormentioning

confidence: 99%

“…In Thai acne patients ( n = 120), adapalene gel 0.1% was shown to be efficacious and tolerable in a double‐blind, randomized, vehicle‐controlled study . However, addition of a non‐comedogenic moisturizer (licochalcone A, L‐carnitine and 1.2‐decanediol) significantly improved tolerability by reducing skin irritation symptoms and TEWL . The efficacy of adapalene was improved by use of moisturizer, because there were fewer inflammatory flares and a more rapid onset of action in reducing acne lesions …”

Section: Using Topical Retinoids In Skin Of Colormentioning

confidence: 99%

“…59 The efficacy of adapalene was improved by use of moisturizer, because there were fewer inflammatory flares and a more rapid onset of action in reducing acne lesions. 59 Kim et al 60 compared the efficacy and tolerability of A-BPO 0.1% versus adapalene gel 0.1% in treatment of Asian patients (n = 23) with acne in a 12-week, split-face, observer-blinded study in Korea. A-BPO 0.1% was significantly superior to adapalene gel monotherapy (P < 0.0001) and while more patients experienced irritation during the first 2 weeks of treatment with A-BPO 0.1%, the authors noted that "all symptoms were tolerable and the prevalence of irritation did not differ between both sides (P > 0.05)".…”

Section: Retinoids In Asian Skinmentioning

confidence: 99%

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Optimizing the use of topical retinoids in Asian acne patients

See¹,

Goh

Hayashi³

et al. 2018

The Journal of Dermatology

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Acne vulgaris is a common disease among people in Asia. International guidelines and treatment recommendations emphasize the central role of topical retinoids in the management of acne. However, topical retinoids remain underutilized in clinical practise, which may be in part due to fear of retinoid‐associated dermatitis/lack of experience, particularly in Asian patients. There is a perception that Asian skin has a greater tendency toward sensitivity compared with Caucasian skin. In our clinical experience, topical retinoid therapy can be used with excellent effect to treat Asians with acne. This article discusses available published work regarding the use of topical retinoids in Asian populations, and presents tips for utilizing these important agents in daily practise. Optimizing use of topical retinoids may improve adherence and, in turn, therapeutic outcomes and patient satisfaction.

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Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021

Miller

Tong

et al. 2022

JAMA Dermatol

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ImportanceAcne and rosacea have substantial implications for quality of life, and it is therefore important to ensure the patient’s voice is being captured in pivotal randomized clinical trials (RCTs). Although patient-reported outcome measures (PROMs) are a valuable tool to capture the patient perspective, little is known about use of PROMs in RCTs on acne and rosacea.ObjectiveTo characterize the use of PROMs in RCTs on acne and rosacea.Evidence ReviewA systematic literature search was conducted using the search terms acne vulgaris and rosacea in the following databases: MEDLINE through PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. A modified search hedge for RCTs from the McGill Library was applied. All phase 2, 3, and 4 RCTs published between December 31, 2011, through December 31, 2021, that evaluated the efficacy and safety of therapies for acne and rosacea vs any comparator were eligible for inclusion.FindingsA total of 2461 publications describing RCTs were identified, of which 206 RCTs met the inclusion criteria (163 trials [79%] on acne and 43 [21%] on rosacea). At least 1 PROM was used in 53% of trials (110) included; PROM use was more common in rosacea RCTs (67% [n = 29]) compared with acne RCTs (50% [n = 81]). At least 1 dermatology-specific (13% [n = 27]) or disease-specific (14% [n = 28]) PROM was included in the RCTs analyzed. Only 7% of trials (14) included a PROM as a primary outcome measure. There was no statistically significant increase in PROM inclusion over the study period (11 of 21 trials in 2011 vs 5 of 12 trials in 2021).Conclusions and RelevanceIn this systematic review, PROMs were included in approximately one-half of acne and rosacea RCTs performed over the study period. In addition, PROMs were rarely used as a primary outcome measure, and inclusion of PROMs has not increased substantially over the past 10 years. Increasing use of PROMs in RCTs can ensure that the patient’s perspective is captured during the development of new treatments for acne and rosacea.

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A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel

Cited by 24 publications

References 31 publications

Chalcones in Dermatology

Chalcones in Dermatology

Optimizing the use of topical retinoids in Asian acne patients

Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021

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