Acylated Oleanane‐Type Triterpene Saponins with Acceleration of Gastrointestinal Transit and Inhibitory Effect on Pancreatic Lipase from Flower Buds of Chinese Tea Plant (Camellia sinensis)

Abstract

The MeOH extract and its BuOH-soluble fraction (crude saponin fraction) from the flower buds of Chinese tea plant (Camellia sinensis (L.) O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. From the BuOH-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, chakasaponins I, II, and III (1-3, resp.), were isolated together with 13 known compounds. The chemical structures 1-3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1-3 showed accelerating effects on gastrointestinal transit in mice and inhibitory effects against porcine pancreatic lipase (IC(50)=150-530 microM).

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

“…Such compounds could be valuable in the prevention of obesity, but studies assessing their effect in HPL are needed to assess their potential. 71 …”

Medicinal Flowers. XXXIII. Anti-hyperlipidemic and Anti-hyperglycemic Effects of Chakasaponins I–III and Structure of Chakasaponin IV from Flower Buds of Chinese Tea Plant (<i>Camellia sinensis</i>)

“…4) In the course of our studies on the saponin compositions of tea flowers cultivated in various provinces of China, we found that floratheasaponins were not contained in the tea flowers cultivated in Fujian province, from which chakasaponins I (2), II (3), III (4), V, and VI were isolated and their structures were determined. 5,6) Previously, we reported inhibitory effects of chakasaponins I-III (2-4) against pancreatic lipase (in vitro), 5) but no anti-hyperglycemic effects and anti-hyper glycemic effects have been reported. In this paper, we describe the effects of principal saponins (2-4) and a principal flavonol glycoside, kaempferol 3 (5), on increases in plasma triglyceride and glucose levels in olive oilor sucrose-loaded mice together with their effects on gastric emptying in mice, rat intestinal α-glucosidase (in vitro) and rat lens aldose reductase (in vitro).…”

Medicinal Flowers. XXXI. Acylated Oleanane-Type Triterpene Saponins, Sasanquasaponins I-V, with Antiallergic Activity from the Flower Buds of Camellia sasanqua

“…However, the pharmacological activities of the flower buds of this plant have not yet characterized. Recently, we have reported the isolation and structure elucidation of triterpene saponins from the flower buds of C. japonica L. (camelliosides A-D), 5,6) C. sinensis L. (chakasaponins I-VI, floratheasaponins A-J), [7][8][9][10][11][12] and C. oleifera ABEL (yuchasaponins A-D).13) Furthermore, those saponins were found to exhibit antiallergic, antidiabetic, antiobestic, gastroprotective, and platelet aggregation activities, etc. …”