Acyl-homoserine lactone-based quorum sensing and quorum quenching hold promise to determine the performance of biological wastewater treatments: An overview

Huang, Jinhui; Shi, Yahui; Zeng, Guangming; Gu, Yanling; Chen, Guiqiu; Shi, Lixiu; Hu, Yi; Tang, Bi; Zhou, Jianxin

doi:10.1016/j.chemosphere.2016.05.032

Cited by 223 publications

(79 citation statements)

References 212 publications

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“…Presently, three types of QS signalling molecules have been discovered in micro‐organisms: the intraspecific signal molecule acylated homoserine lactones (AHLs), the interspecific QS signal molecule auto‐inducer‐2 (AI‐2), and the intraspecific and interspecific signal molecule diffusion signal factor (Feng et al ; Lade et al ; Huang et al ). AHLs are secreted by Gram‐negative bacteria, and they contain carbon chains of different lengths from C4 to C14 and a homoserine lactone ring (Huang et al ). When AHLs accumulate and their concentration becomes greater than a certain threshold, AHLs bind to the receptor protein (PN) LuxR and activate the expression of related genes (Teng et al ; Galloway et al ).…”

Section: Introductionmentioning

confidence: 99%

Dynamic characteristics of AHLs‐secreting strainAeromonassp. A‐L2 and its bioaugmentation during quinoline biodegradation

Gao

Liu

et al. 2019

J Appl Microbiol

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Aims In order to probe a more environmentally friendly method of pollutant treatment based on microbial bioaugmentation and quorum sensing (QS) effects. Methods and Results The dynamic characteristics and QS effects of the acylated homoserine lactones (AHLs)‐secreting strain Aeromonas sp. A‐L2 (A‐L2), which was isolated from the activated sludge system, was discussed. According to the liquid chromatography‐mass spectrometry results, N‐butyryl‐homoserine lactone (C4‐HSL) and N‐hexanoyl‐homoserine lactone (C6‐HSL) were the major AHLs secreted by strain A‐L2, and the swarming of strain Ochrobactrum sp. LC‐1 (LC‐1) was induced by these compounds. The extracellular polymeric substance secretion of the strain LC‐1 was mainly led by C6‐HSL, and the biofilm formation ability was mainly influenced by C6‐HSL or C4‐HSL (60 μg l−1). The optimal AHLs secretion conditions of strain A‐L2 were also studied. Drawing support from the AHLs‐secreting strain A‐L2 during quinoline degradation by strain LC‐1, the degradation time was greatly shortened. Conclusions Hence, AHLs‐secreting strain A‐L2 can be useful as an AHLs continuous supplier during bioaugmentation and pollutant biodegradation. Significance and Impact of the Study The bioaugmentation process of strain A‐L2 on quinoline biodegradation based on QS effects would lay a certain theoretical and practical significance for large‐scale applications.

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Section: Introductionmentioning

confidence: 99%

Dynamic characteristics of AHLs‐secreting strainAeromonassp. A‐L2 and its bioaugmentation during quinoline biodegradation

Gao

Liu

et al. 2019

J Appl Microbiol

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“…Since then, several studies have demonstrated that QSI compounds are capable of reducing the formation of biofilm and further inhibit the development of biofouling (Cushnie and Lamb, 2011; Dobretsov et al ., 2011; Karina et al ., 2013). Some antifouling substances have recently been identified in microbes and plants (and even animals); these are peptide compounds, such as quorum‐quenching enzyme and small‐molecule compounds (Huang et al ., 2016; Bzdrenga et al ., 2017). Of particular note, is furanone, a traditional inhibitor that is a potent antagonist of Gram‐negative bacteria (Hentzer et al ., 2003), and a type of long‐chain fatty aldehyde, identified as pentadecanal, which acts against Staphylococcus epidermidis biofilm (Casillo et al ., 2017), as well as the 2‐sufonylpyrimidines which can significantly inhibit Pseudomonas aeruginosa biofilm (Thomann et al ., 2016).…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm activity substances derived from coral symbiotic bacterial extract inhibit biofouling by the model strainPseudomonas aeruginosaPAO1

Song

Cai

Lao

et al. 2018

Microbial Biotechnology

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SummaryThe mitigation of biofouling has received significant research attention, with particular focus on non‐toxic and sustainable strategies. Here, we investigated quorum sensing inhibitor (QSI) bacteria as a means of controlling biofouling in a laboratory‐scale system. Approximately, 200 strains were isolated from coral (Pocillopora damicornis) and screened for their ability to inhibit quorum sensing (QS). Approximately, 15% of the isolates exhibited QSI activity, and a typical coral symbiotic bacterium, H12‐Vibrio alginolyticus, was selected in order for us to investigate quorum sensing inhibitory activity further. Confocal microscopy revealed that V. alginolyticus extract inhibited biofilm formation from Pseudomonas aeruginosa PAO1. In addition, the secondary metabolites of V. alginolyticus inhibited PAO1 virulence phenotypes by downregulating motility ability, elastase activity and rhamnolipid production. NMR and MS spectrometry suggested that the potential bioactive compound involved was rhodamine isothiocyanate. Quantitative real‐time PCR indicated that the bacterial extract induced a significant downregulation of QS regulatory genes (lasB, lasI, lasR, rhlI, rhlR) and virulence‐related genes (pqsA, pqsR). The possible mechanism underlying the action of rhodamine isothiocyanate analogue involves the disruption of the las and/or rhl system of PAO1. Our results highlight coral microbes as a bioresource pool for developing QS inhibitors and identifying novel antifouling agents.

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“…Recently, a novel perspective was proposed for biofouling control based on quorum sensing (QS) . Quorum sensing (QS) is known as a bacterial behavior, which is density‐dependent cell‐to‐cell communication using signal molecules produced and recognized by microorganism when their signal molecules reached threshold .…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19] Recently, a novel perspective was proposed for biofouling control based on quorum sensing (QS). 20,21 Quorum sensing (QS) is known as a bacterial behavior, which is density-dependent cell-to-cell communication using signal molecules produced and recognized by microorganism when their signal molecules reached threshold. 22,23 QS could regulate gene expression so as to mediate some bacterial behaviors such as the production of soluble microbial products (SMP) and extracellular polymeric substances (EPS), and biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

Quorum quenching activity of indigenous quorum quenching bacteria and its potential application in mitigation of membrane biofouling

Huang

Zeng

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND Quorum sensing (QS) could regulate gene expression so as to mediate some bacterial behaviors such as the production of extracellular polymeric substances (EPS) and biofilm formation. In this study, a quorum quenching (QQ) bacterium was isolated from an indigenous lab‐scale membrane bioreactor (MBR) and encapsulated in a dumpling‐shaped microbial bag for biofouling control. RESULTS This QQ bacteria has a higher genetic homology with Acinetobacter bereziniae strain. The effect of time and temperature on the QQ activity of the microbial bag was tested by degrading N‐acyl homoserine lactone (AHL). The results showed the degradation of C8‐HSL (N‐Octanoyl‐DL‐homoserine lactone) and C6‐HSL (N‐Hexanoyl‐L‐homoserine lactone) could reach equilibrium within 2 h. In addition, a suitable temperature for AHL degradation was 20 °C, at which the rate of degradation of C6‐HSL and C8‐HSL by the microbial bag was 88% and 69%, respectively. The antifouling efficiency of the microbial bag was investigated by a constant pressure filtration system. With the microbial bag added, the decrease of permeability was obviously improved. After 14 days, the permeability with QQ decreased to 18% while the control experiment exhibited almost no permeability. CONCLUSION The excellent AHL degradation rate and the filtration test showed that this QQ bacteria has an excellent antifouling potential in membrane filtration systems. © 2017 Society of Chemical Industry

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Acyl-homoserine lactone-based quorum sensing and quorum quenching hold promise to determine the performance of biological wastewater treatments: An overview

Cited by 223 publications

References 212 publications

Dynamic characteristics of AHLs‐secreting strainAeromonassp. A‐L2 and its bioaugmentation during quinoline biodegradation

Dynamic characteristics of AHLs‐secreting strainAeromonassp. A‐L2 and its bioaugmentation during quinoline biodegradation

Antibiofilm activity substances derived from coral symbiotic bacterial extract inhibit biofouling by the model strainPseudomonas aeruginosaPAO1

Quorum quenching activity of indigenous quorum quenching bacteria and its potential application in mitigation of membrane biofouling

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