Acyl-CoA synthase and acyltransferase activity in developing skeletal muscle membranes

Smith, P.Blaise; Reitz, Ronald C.; Kelley, Deborah A.

doi:10.1016/0005-2760(82)90175-8

Cited by 12 publications

(2 citation statements)

References 18 publications

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“…The acyl-CoA formation is a prerequisite for both phospholipid fatty acid acylation and oxidation to provide energy [15], while nonactivated, free arachidonic acid is required for eicosanoid synthesis [16]. Arachidonic acid does not serve as an energy source, but the formation of arachidonoyl-CoA is pivotal for either phospholipid incorporation or eicosanoid synthesis.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Kinetic Properties of Renal Arachidonoyl-CoA Synthetase during Development in the Rat

D’Antuono¹,

Kahane²,

Sterín-Speziale³

1998

Neonatology

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Changes in endogenous levels of phospholipid arachidonic acid and in its radioactive incorporation can be detected in the rat kidney medulla during maturation. In an effort to explain this phenomenon, the arachidonoyl-CoA synthetase activity in the neonatal (10 days of age) and adult kidney (70-day-old rats) were studied. The neonatal kidney enzyme showed greater affinity, but less capacity than the adult enzyme to incorporate arachidonic acid into the membrane. The apparent K_m values were 27.8 and 73.9 µM while the v_max was 3.68 and 15.7 nmol/min/mg protein, for 10 and 70 days of age, respectively. Affinity for ATP was found to be almost 7-fold greater in adults when compared to neonates. The v_max for ATP also increased during development, with values of 1.04 and 2.87 at 10 and 70 days of age, respectively. Affinity for coenzyme A did not vary between the two stages studied, though the v_max increased 10-fold from 10 to 70 days of age. Since arachidonic acid availability is low in the perinatal stage because of its restricted endogenous synthesis, the higher enzyme affinity for this fatty acid at 10 days of age described here, could be of great importance in helping to capture the low but indispensable amount of arachidonic acid present in maternal milk during lactation.

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Section: Discussionmentioning

confidence: 99%

Changes in the Kinetic Properties of Renal Arachidonoyl-CoA Synthetase during Development in the Rat

D’Antuono¹,

Kahane²,

Sterín-Speziale³

1998

Neonatology

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“…10 Acyl-CoA synthase activity in mouse heart is reportedly 14 times greater at birth than in the embryonic period, and it is 1.4-1.6 times greater in newborn than in adult rabbit skeletal muscle. 30,31 Although no data are available on the postnatal development of these enzymes in humans, it is reasonable to assume that chiral inversion is well developed in human neonates too.…”

Section: Discussionmentioning

confidence: 99%

Ibuprofen enantiomers in premature neonates with patent ductus arteriosus: Preliminary data on an unexpected pharmacokinetic profile of S(+)‐ibuprofen

et al. 2021

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S(+)-ibuprofen (S-IBU) and R(−)-ibuprofen (R-IBU) concentrations were measured in 16 neonates with patent ductus arteriosus during a cycle of therapy (three intravenous doses of 10-5-5 mg kg −1 at 24-h intervals), at the end of the first infusion and 6, 24, 48, and 72 h later. Data were analyzed with a PK model that included enantiomer elimination rate constants and the R-to S-IBU conversion rate constant. The T½ of S-IBU in the newborn was much longer than in adults (41.8 vs. ≈2 h), whereas the T½ of R-IBU appeared to be the same (2.3 h). The mean fraction of R-to S-IBU conversion was much the same as in adults (0.41 vs. ≈0.60). S-IBU concentrations measured 6 h after the first dose were higher than at the end of the infusion in 10 out of 16 cases, and in five cases, they remained higher even after 24 h. This behavior is unprecedented and may be attributable to a rapid R-to-S conversion overlapping with a slow S-IBU elimination rate. In 13 of the 16 neonates, S-IBU concentrations at 48 and/or 72 h were lower than expected, probably due to the rapid postnatal maturation of the newborn's liver metabolism.

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Beeinflussung des Lands Zyklus durch Inhibitoren und Cofaktoren

1988

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und y-Linolensaure eine Rolle, da bei den endogenen Ekzematikem unter Therapie eine Konzentrationserhohung der Metaboliten des Linolsaurestoffwechsels zu beobachten ist. Aus unseren kinetischen Studien ist die hohe Metabolisierungsgeschwindigkeit der mehrfach ungesattigten Fettsauren zu erkennen. Hier liegt sicherlich eine Ursache fiir die in der Literatur gefundenen widerspriichhchen Fettsaureverteilungsmuster, denn dieser schnelle Abbau impliziert eine zeitlich genau standardisierte Blutentnahme nach der letzten oralen Applikation.Ungeklart bleibt letztlich immer noch die Frage nach der biologischen Funktionsweise der mehrfach ungesattigten Fettsauren beim endogenen Ekzem. Hierzu sind weitere Untersuchungen im Bereich der sich dynamisch iindernden Membranstrukturen und i m Bereich des Auf-bzw. Abbaus der Prostaglandine notwendig. L i t e r a t u r I G. 0. Burr u. M. M. Burr, J. Biol. Chem. 82,345 [1929].

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Acyl-CoA synthase and acyltransferase activity in developing skeletal muscle membranes

Cited by 12 publications

References 18 publications

Changes in the Kinetic Properties of Renal Arachidonoyl-CoA Synthetase during Development in the Rat

Changes in the Kinetic Properties of Renal Arachidonoyl-CoA Synthetase during Development in the Rat

Ibuprofen enantiomers in premature neonates with patent ductus arteriosus: Preliminary data on an unexpected pharmacokinetic profile of S(+)‐ibuprofen

Beeinflussung des Lands Zyklus durch Inhibitoren und Cofaktoren

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