Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2′-deoxy-5-ethyl-4′-thiouridine

A Fe3O4@SiO2/Schiff Base/Pd Complex as an Efficient Heterogeneous and Recyclable Nanocatalyst for One‐Pot Domino Synthesis of Carbamates and Unsymmetrical Ureas

“…Furthermore, these compounds present very significant roles in various fields of chemical sciences including amine protecting groups specially in the peptide synthesis, as directing groups in nucleoside synthesis, as versatile intermediates in the manufacturing and even in the synthesis of fertilizers, herbicides, pesticides, polyurethane foams plastics, synthetic rubber, artificial leather, fabric and adhesive agents…”

Enabling the facile conversion of acyl hydrazides into N-acyl carbamates via metal-free ionic-based rupture of the N–N linkage

“…Owing to the importance of N-acyl carbamates in various bioactive compounds, [10][11][12][13] e.g. anti-malassezia agents, 10 insecticides, 11 antibiotics, 12 and pro-drugs, 13 its use as a directing a group in synthesis, 14,15 as well as phototriggers, 16 there was plenty of incentive to explore this chemistry. Further to this, the synthetic strategy proposed in this article is complementary to existing traditional approaches for the synthesis of N-acyl carbamates, which tend to react acyl halides with carbamates or primary/secondary amides with chloroformates.…”

Practical Synthesis of 2‘-Deoxy-4‘-thioribonucleosides: Substrates for the Synthesis of 4‘-ThioDNA

“…However since then, nothing has been published on the use of 4‘-thioDNA as a functional DNA molecule despite the favorable properties of 4‘-thioDNA. This is probably due in large part to the difficulty of synthesizing 2‘-deoxy-4‘-thioribonucleosides. , Haraguchi et al have recently reported the stereoselective synthesis of 2‘-deoxy-4‘-thioribonucleosides based on electrophilic glycosidation of 4-thiofuranoid glycals . Although this method involves interesting chemistry, the reactions were all carried out on a very small scale.…”