Acute zinc deficiency and trabecular bone loss in rats with talc granulomatosis

Marušić, Ana; Kos, Ksenija; Stavljenić, A; Vukičević, Slobodan

doi:10.1007/bf03032694

Cited by 3 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Krempien et al have shown the cellular mechanism of bone loss to include transient osteoblastic insufficiency, growth failure and intact bone resorption (98). An increased intake of zinc in the food and application of cortisone elicit a certain protective effect on the bone in these rats, but neither zinc nor corticosteroids act äs a direct transmitter of the inflammatory effect on the bone (97,(103)(104)(105). Thus, the authors have ruled out parathyroid hormone, vitamin D 3 and prostaglandins äs possible causes of bone mass loss (93, 99 -101).…”

Section: Inflammation-induced Osteopeniamentioning

confidence: 99%

Review

Cesnjaj

Stavljenić

Vukičević

1991

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

A better insight into bone pathophysiology is required for a füll understanding of the mechanisms leading to bone loss in humans. Animal models of bone disease appear to be the most valuable for this purpose. Certain differeiices in bone metabolism exist between various species. Non-human primates are the most human-compatible animai species, whereas dogs appear to be most appropriate among small laboratory animals. However, the high cost of studies on primates and dogs restricts the number of animals examined. The rat is the most frequently used animal. Many similarities have been observed in bone metabolism of humans and rats. Like humans, rats also lose bone with aging, and in some parts of the rat skeleton bone remodelling occurs. However, bone metabolism in rat is mainly characterized by growth and modelling, which makes the rat model completely appropriate for studies of juvenile osteopenias. Characteristics of animal models of osteopenias should be comprehensively investigated in order to render the study results completely, or with known exceptions, comparable to the corresponding processes in humans.

show abstract

Section: Inflammation-induced Osteopeniamentioning

confidence: 99%

Review

Cesnjaj

Stavljenić

Vukičević

1991

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

show abstract

Copper and zinc body levels in inflammation: An overview of the data obtained from animal and human studies

et al. 1993

View full text Add to dashboard Cite

The development of acute and chronic inflammatory processes induces, in the laboratory animal, a net accumulation of both copper and zinc in many body compartments, the inflamed area included. In rheumatoid arthritis, as well as in animal models, only plasma zinc concentration seems to be significantly correlated with disease severity, while the increase in total plasma copper could be described as an "all or nothing" phenomenon. Moreover, in rheumatoid arthritis, it appears that the disease develops and progresses without being linked to either copper or zinc deficiency conditions. Thus, it seems reasonable to suggest that a rationale for the use of copper and/or zinc in the treatment of inflammatory disorders can only be drawn from the intrinsic pharmacological properties of such trace elements, rather than from the need for their repletion.

show abstract

Untitled

Johal¹,

Mendoza-Suárez²,

Escalante-Garcı́a³

et al. 2002

Journal of Materials Science: Materials in Medicine

View full text Add to dashboard Cite

In this study the osteoconductive properties of strontium based ionomeric cements (ICs) named, LG125 and LG119, as well as zinc-based ICs, designated by LG130 and LG132, were compared. Wet ICs were surgically implanted into the femora of weaned Wistar rats for 4 weeks. To assess the percentage osseointegration the perimeter of the implant and the perimeter of bone in contact with the implant were measured using a pointer (the length of bone/implant interfacial contact). Osteoconduction was determined by taking six points at random around the perimeter of each ionomeric rod measuring the thickness of newly formed bone. The degree of osteoconduction was taken as the average thickness of new bone produced on the implant surface. It was found that osteoconduction was greatest in the strontium based IC implant LG125. From these studies it can be concluded that the composition LG125 might provide a useful purpose as a bone cement.

show abstract

Acute zinc deficiency and trabecular bone loss in rats with talc granulomatosis

Cited by 3 publications

References 16 publications

Review

Review

Copper and zinc body levels in inflammation: An overview of the data obtained from animal and human studies

Untitled

Contact Info

Product

Resources

About